R 35 Regulation of the peritoneal macrophage functional activity by the MP-5 and MP-6 myelopeptides under stress / S. V. Gein, T. V. Gavrilova, O. N. Gein [et al.] // Doklady Biological Sciences. - 2017. - Vol. 475, № 1. - P154-156 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): PEPTIDES -- MACROPHAGES -- ACTIVE OXYGEN Аннотация: In mice, two-hour immobilization stress inhibited zymosan-induced production by macrophages of the oxygen radicals and cytokine IL-1[beta]. After myelopeptides MP-5 and MP-6 were administered into mice, the stress-induced inhibition of the reactive oxygen species (ROS) and IL-1[beta] was abrogated. MP-5 peptide stimulated spontaneous ROS production by macrophages and reduced IL-10 production under stress. Thus, under in vivo conditions and under stress, the effect of MP-5 and MP-6 myelopeptides modulates the peritoneal macrophage activity. \\\\Expert2\\NBO\\Doklady Biological Sciences\\2017. - Vol. 475, № 1. - P. 154.pdf |