Вид документа : Статья из журнала Шифр издания : Автор(ы) : Shinwari K., Bolkov M. A., Tuzankina I. A., Chereshnev V. A. Заглавие : Newborn Screening through TREC, TREC/KREC system for Primary Immunodeficiency with limitation of TREC/KREC. Comprehensive review Место публикации : Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry. - 2021. - Vol. 20. - С. 132-149 Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): primary immunodeficiency--t-cell lymphopenia Аннотация: Newborn screening (NBS) by quantifying T cell receptor excision circles (TRECs) and Kappa receptor excision circles in neonatal dried blood spots (DBS) enables early diagnosis of different types of primary immune deficiencies. Global newborn screening for PID, using an assay to detect T-cell receptor excision circles (TREC) in dried blood spots (DBS), is now being performed in all states in the United States. In this review, we discuss the development and outcomes of TREC, TREC/KREC combines screening, and continued challenges to implementation. Доп.точки доступа: Shinwari, K.; Bolkov, M. A.; Tuzankina, I. A.; Chereshnev, V. A.