S 98 Synthesis of 1-substituted 2-azaspiro[4.5]deca-6,9-diene-8-ones and 2-azaspiro[4.5]deca-1,6,9-triene-8-ones by a three-component condensation of 1,2,3-, 1,2,4- or 1,3,5-trimethoxybenzene with isobutyric aldehyde and nitriles [Text] / V. A. Glushkov, O. G. Stryapunina, A. A. Gorbunov, O. A. Maiorova, P. A. Slepukhin, S. Ya. Ryabukhina, E. V. Khorosheva, V. I. Sokol, Yu. V. Shklyaev // Tetrahedron. - 2010. - Vol. 66, № 3. - P721-729 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A three-component condensation of 1,2,3- or 1,2,4-trimethoxybenzene with isobutyric aldehyde and alkyl cyanoacetates in the presence of sulfuric acid resulted in the formation of substituted 2-azaspiro[4.5]deca-6,9-diene-8-ones. The same reaction of aromatic nitriles yielded 2-azaspiro[4.5]deca-1,6,9-triene-8-ones; in the case of 1,2,3-trimethoxybenzene corresponding Ritter amides were also observed. The condensation of 1,3,5-trimethoxybenzene with isobutyric aldehyde and alkyl cyanoacetates provided the compounds of the formal Knoevenagel condensation \\\\Expert2\\nbo\\Tetrahedron\\2010, v.66, N 3,p.721.pdf |