O-57 One-Pot, Three-Component Synthesis of Novel Pyrroloacridinones via Intramolecular ipso Dearomatization–Intramolecular Aza-Michael Addition Sequence [Electronic resource] / Y. S. Rozhkova, K. A. Galata, A. A. Gorbunov, Yu. V. Shklyaev, M. A. Ezhikova, M. I. Kodess // Synlett. - 2014. - Vol. 25, № 18. - С. 2617-2623 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): INTRAMOLECULAR IPSO DEAROMATIZATION -- SPIRO-SUBSTITUTED CYCLOHEXA-2,5-DIENONE -- DOMINO REACTION Аннотация: A one-pot, three-component synthesis of novel pyrroloacridinones from a set of alkoxy arenes and 2,6-dialkylphenols, isobutyric aldehyde, and 2-aminobenzonitrile is described. We have demonstrated the efficacy of the combination of intramolecular electrophilic ipso dearomatization of suitable aromatic compounds leading to spiro-substituted cyclohexa-2,5-dienones and intramolecular aza-Michael addition for the preparation of complex aza-heterocyclic systems. \\\\expert2\\nbo\\Synlett\\2014, V.25, p. 2617.pdf |