Вид документа : Шифр издания : 54/S 98 Автор(ы) : Vigorov A. Yu., Nizova I. A., Shalunova K. E., Grishakov A. N., Sadretdinova L. Sh., Ganebnuikh I. N., Ezhikova M. A., Kodess M. I. Заглавие : Synthesis of the (2S,4S)-stereoisomers of 4-(indol-1-yl) and 4-arylamino derivatives of 5-oxoproline, proline, and 2-hydroxymethylpyrrolidine Место публикации : Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2011. - Vol.60, №5. - С. 873-881 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 4-aminoproline--4-aminoproline--indole Аннотация: Nucleophilic substitution of the halogen atom in dimethyl (S)-4-bromoglutamate followed by removal of the protecting groups and closure of a lactam ring afforded (2S,4S)-4-(indolin-1-yl)-5-oxoproline. The indoline fragment was oxidized into the indole fragment to give (2S,4S)-4-(indol-1-yl)-5-oxoproline; reduction of the carbonyl groups with BH3 yielded (2S,4S)-4-(indol-1-yl)prolines and (2S,4S)-2-hydroxymethyl-4-(indol-1-yl)pyrrolidines. Reduction of (2S,4S)-4-arylamino-5-oxoprolines with BH3 to the corresponding (2S,4S)-4-arylaminoprolines and (2S,4S)-4-arylamino-2-hydroxymethylpyrrolidines was studied Доп.точки доступа: Vigorov, A. Yu.; Nizova, I. A.; Shalunova, K. E.; Grishakov, A. N.; Sadretdinova, L. Sh.; Ganebnuikh, I. N.; Ганебных Илья Николаевич; Ezhikova, M. A.; Kodess, M. I.; Кодесс Михаил Исаакович