Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Pereslavceva A. V., Tolmacheva I. A., Slepukhin P. A., Eltsov O. S., Kucherov I. I. , Eremin V. F., Grishko V. V. Заглавие : Synthesis of A-Pentacyclic Triterpene α,β-Alkenenitriles [Электронный ресурс] Место публикации : Chemistry of Natural Compounds. - 2014. - Vol.49, №6. - С. 1059-1066 Систем. требования: http://download.springer.com/static/pdf/917/art%253A10.1007%252Fs10600-014-0822-2.pdf?auth66=1397205289_e2291bf44b21c8d7aca0a675ff76a144&ext=.pdf Примечания : Bibliogr. : p. 1066 (24 ref.). - 09.04.2014 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): alfa,beta- alkenenitriles--a-seco-triterpenoids--allobetulone Аннотация: A-seco-triterpenoids with a methylketone group were synthesized from epimeric 3-hydroxy-3-methyl-1-cyano-2,3-seco-triterpenoids of the lupane and 19β,28-epoxy-18αH-oleanane types, which were formed by a Grignard reaction. The resulting methylketones underwent under base-catalysis conditions an intramolecular cyclization to form A-pentacyclic β-substituted alkenenitriles. The synthesized compounds included 3-methyl-1-cyano-19β,28- epoxy-2,3-seco-2-nor-18αH-olean-3-one and methyl 3-methyl-1-cyano-2- norlup-1(3),20(29)-dien-28-oate, which inhibited in vitro reproduction of human immunodeficiency virus type 1. Доп.точки доступа: Pereslavceva, A. V.; Tolmacheva, I. A.; Slepukhin, P. A.; Eltsov, O. S.; Kucherov, I. I. ; Eremin, V. F.; Grishko, V. V.