Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Khalymbadzha I. A., Deev S. L., Shestakova T.S., Rusinov V. L., Chupakhin O. N. Заглавие : Synthesis of acyclic nucleoside analogues by one-step vorbrUggen glyco-sylation of 1,2,4-triazolo[1,5-a]pyrimidine-7-ones [Электронный ресурс] Место публикации : Chimica Techno Acta. - 2015. - Vol. 2, № 2. - С. 158-160 Систем. требования: http://elibrary.ru/item.asp?id=23785881 Примечания : Bibliogr. : p. 160 (4 ref.). - 2.12.15 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): acyclovir Аннотация: New analogues of acyclovir have been prepared by reacting 1,2,4 -triazolo[1,5-a]pyrimidin-7-ones 1а-i and (2-acetoxyethoxy)methyl acetate 2 in the presence of trimethylsilyl trifluoromethanesulfonate as a catalyst. The interaction between the compounds 1а-е and 2 has led to a mixture of N3 and N4 isomers. In contrast, the reaction of compounds 1g-i and 2 proceeded selectively to form N3 isomers. In the case of compounds 1a-c the predominant product is the one with the acyclic moiety in azine ring (N4 isomer). Interaction between 1d-f and 2 has led to mixtures comprising mainly N3 isomer. It has been found that the ratio of glycosylation products 1 and 2 are thermodynamically controlled. The structure of the obtained compounds has been proved by 1Н, 13С, two-dimensional 1Н-13С NMR spectroscopy and X-ray analysis. Доп.точки доступа: Khalymbadzha, I. A.; Deev , S. L.; Shestakova, T.S.; Rusinov, V. L.; Chupakhin, O. N.