Вид документа : Статья из журнала Шифр издания : 54/S 98 Автор(ы) : Verbitskiy E. V., Slepukhin P. A., Kravchenko M. A., Skornyakov S. N., Evstigneeva N. P., Kungurov N. V., Zil'berberg N. V., Rusinov G. L., Chupakhin O. N., Charushin V. N. Заглавие : Synthesis, antimycobacterial and antifungal evaluation of some new 1-ethyl-5-(hetero)aryl-6-styryl-1,6-dihydropyrazine-2,3-dicarbonitriles [Электронный ресурс] Место публикации : Bioorganic and Medicinal Chemistry Letters. - 2015. - Vol. 25, № 3. - С. 524-528 Систем. требования: http://apps.webofknowledge.com/ Примечания : Bibliogr. : p. 528 (16 ref.). - 18.01.2016 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): pyrazines--antituberculosis activity--petasis reaction Аннотация: The Petasis reaction of 6-hydroxy adducts of 1-alkyl-2,3-dicyano-5-arylpyrazinium salts with trans-styrylboronic acids proved to proceed smoothly at room temperature to give the corresponding 5-(hetero)aryl-6-styryl substituted 1,6-dihydropyrazine derivatives. Also it has been found that C(6) unsubstituted 1,6-dihydro- or 1,4,5,6-tetrahydropyrazine derivatives can be easy prepared in high yields from the corresponding pyrazinium salts by reduction with triethylsilane. All synthesized compounds were screened in vitro for their antifungal activities against seven pathogenic fungal strains and antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv, avium, terrae and multi-drug-resistant strains isolated from tuberculosis patients in the Ural region (Russia) Доп.точки доступа: Verbitskiy, E. V.; Slepukhin, P. A.; Kravchenko, M. A.; Skornyakov, S. N.; Evstigneeva, N. P.; Kungurov, N. V.; Zil'berberg, N. V.; Rusinov, G. L.; Русинов Геннадий Леонидович; Chupakhin, O. N.; Charushin, V. N.