Вид документа : Статья из журнала Шифр издания : 61/S 98 Автор(ы) : Sidorova L. P., Tseitler T. A., Perova N. M., Emel’yanov V. V., Savateeva E. A., Maksimova N. E., Mochul’skaya N. N., Chereshnev V. A., Chupakhin O. N. Заглавие : Synthesis of New 1,3,4-Thiadiazines Capable of Inhibiting Nonenzymatic Glycosylation of Proteins [Электронный ресурс] Место публикации : Pharmaceutical Chemistry Journal. - 2015. - Vol. 49, № 8. - С. 501-505 Систем. требования: http://link.springer.com/article/10.1007/s11094-015-1314-9 Примечания : Bibliogr. : p. 505 (12 ref.). - 19.01.2016 ББК : 61 + 54 Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): 1,3,4-thiadiazine --cyclocondensation--nonenzymatic glycosylation of proteins--thiosemicarbazides Аннотация: A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing Доп.точки доступа: Sidorova, L. P.; Tseitler, T. A.; Perova, N. M.; Emel’yanov, V. V.; Savateeva, E. A.; Maksimova, N. E.; Mochul’skaya, N. N.; Chereshnev, V. A.; Chupakhin, O. N.