Вид документа : Статья из журнала Шифр издания : 54/E 27 Автор(ы) : Chizhov D. L., Belyaev D. V., Yachevskii D. S., Rusinov G. L., Chupakhin O. N., Charushin V. N. Заглавие : Efficient and scalable synthesis of 3-(polyfluoroacyl)pyruvaldehydes dimethyl acetals: A novel functionalized fluorinated building-block Место публикации : Journal of Fluorine Chemistry. - 2017. - Vol. 199. - С. 39-45 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): fluorinated 1,3-diketones--acetals--claisen condensation--calcium hydride--3-(polyfluoracyl)pyruvaldehydes--pyrazole-1h-3- carbaldehydes Аннотация: An efficient approach for the synthesis of 3-(polyfluoroacyl)pyruvaldehydes dimethyl acetals (1,1-dimethoxy-4-polyfluoroalkyl-butan-2,4-dions) from 1,1-dimethoxyacetone and polyfluorinated carboxylic acid esters has been developed. The procedure includes the Claisen type condensation of the starting materials by means of calcium hydride in methanol, followed by isolation of copper complexes of the corresponding diketones and their destroying with disodium EDTA. A simple synthesis of 5(3)-(polyfluoroalkyl)-1H-pyrazole-3(5)-carbaldehydes and their acetals is also presented. Доп.точки доступа: Chizhov, D. L.; Belyaev, D. V.; Yachevskii, D. S.; Rusinov, G. L.; Chupakhin, O. N.; Charushin, V. N.