Вид документа : Статья из журнала Шифр издания : Автор(ы) : Filatova E. S., Fedorova O. V., Chistyakov K. A., Rusinov G. L., Charushin V. N. Заглавие : Features of a multicomponent biginelli reaction involving 3-oxobutanoyl-containing podands, aromatic aldehydes, and 1,2,4-triazol-3-amine Место публикации : Chemistry of heterocyclic compounds. - 2020. - Vol. 56, № 1. - С. 88-91 Ключевые слова (''Своб.индексиров.''): dihydropyrimidine--monosubstituted podand--podand--triazolo[1,5-а]pyrimidine--triazolo[4,3-а]pyrimidine--tuberculostatic activity Аннотация: [Figure not available: see fulltext.] A reaction of 3-oxobutanoyl-containing podands with thiophene-2-carbaldehyde (or benzaldehyde) and 3-amino-1,2,4-triazole gave podands featuring a 4,7-dihydro[1,2,4]triazolo[1,5-а]pyrimidine motif. It was established that the process was accompanied by the formation of [4,3-а]-isomers, which occurred in a slight excess during the synthesis of a podand containing a phenyl group at position 7 and, on the other hand, were observed as the minor products during the synthesis of podands bearing a thiophen-2-yl substituent. Trace amounts of monosubstituted podands were also detected, containing a free hydroxy group along with the triazolodihydropyrimidine pharmacophore. Доп.точки доступа: Filatova, E. S.; Fedorova, O. V.; Федорова Ольга Васильевна; Chistyakov, K. A.; Rusinov, G. L.; Charushin, V. N.