Вид документа : Статья из журнала Шифр издания : Автор(ы) : Sadykhov G., Belyaev D. V., Pervova M. G., Rusinov G. L., Verbitskiy E. V., Chupakhin O. N., Charushin V. N., Vakhrusheva D. V., Eremeeva N. I., Khramtsova E. E. Заглавие : New approach to biologically active indolo[2,3-b]quinoxaline derivatives through intramolecular oxidative cyclodehydrogenation Место публикации : ChemistrySelect. - 2022. - Vol. 7, № 18. - С. e202200497 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A convenient synthetic protocol to antiviral agent B-220 and a series of similar indolo[2,3-b]quinoxaline derivatives has been developed. This synthetic approach is based on Buchwald-Hartwig cross-coupling and subsequent annulation by intramolecular oxidative cyclodehydrogenation. For the first time, 6H-indolo[2,3-b]quinoxaline amine derivatives were evaluated for antimycobacterial activity. The moderate bacteriostatic effect against Mycobacterium tuberculosis H37Rv was found. A plausible mechanism of antibacterial action was elucidated by the molecular docking. Доп.точки доступа: Sadykhov, G.; Belyaev, D. V.; Pervova, M. G.; Rusinov, G. L.; Русинов Геннадий Леонидович; Verbitskiy, E. V.; Chupakhin, O. N.; Charushin, V. N.; Vakhrusheva, D. V.; Eremeeva, N. I.; Khramtsova, E. E.