Вид документа : Шифр издания : 54/C 73 Автор(ы) : Verbitskiy E. V., Cherprakova E. M., Slepukhin P. A., Kodess M. I., Ezhikova M. A., Pervova M. G., Rusinov G. L., Chupakhin O. N., Charushin V. N. Заглавие : Combination of the Suzuki–Miyaura cross-coupling and nucleophilic aromatic substitution of hydrogen (HSN) reactions as a versatile route to pyrimidines bearing thiophene fragments Место публикации : Tetrahedron. - 2012. - Vol.68, №27-28. - С. 5445-5452 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): suzuki–miyaura --cross-coupling --pyrimidines Аннотация: It has been shown that combination of the Suzuki–Miyaura cross-coupling and nucleophilic aromatic substitution of hydrogen is a versatile method for the synthesis of 4-(thiophen-2-yl)-, 5-(thiophen-2-yl)-, and 4,5-di(thiophen-2-yl) substituted pyrimidines from the commercially available 5-bromopyrimidine. The HSN (AE)- and HSN (AO)-reactions of 5-bromopyrimidine with thiophene and 2-bromothiophene have been studied by gas–liquid chromatography/mass-spectrometry. The structures of intermediate σH-adducts, as well as thiophene-(thiophenyl)pyrimidine and bithiophene-(thiophenyl)pyrimidine dyads have first been established by X-ray crystallography analysis Доп.точки доступа: Verbitskiy, E. V.; Cherprakova, E. M.; Slepukhin, P. A.; Kodess, M. I.; Кодесс Михаил Исаакович; Ezhikova, M. A.; Pervova, M. G.; Rusinov, G. L.; Русинов Геннадий Леонидович; Chupakhin, O. N.; Charushin, V. N.