Вид документа : Шифр издания : 54/S 98 Автор(ы) : Lipunova G. N., Nosova E. V., Laeva A. A., Charushin V. N. Заглавие : Synthesis and antiviral activity of fluorine-containing 4-arylaminoquinazolines Место публикации : Pharmaceutical Chemistry Journal. - 2012. - Vol.45, №12. - С. 709-711 ББК : 54 Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ Ключевые слова (''Своб.индексиров.''): antiviral activity--4-arylaminoquinazolines--intramolecular cyclizations Аннотация: 2-Methylthio-4-phenylamino-6,7,8-trifluoro-3H-quinazolin-4-one was synthesized by means of intramolecular cyclizations of S-methyl-N-(tetrafluorobenzoyl)isothiourea followed by a reaction with POCl3 and nucleophilic substitution at the 4-position. The reactions of the synthesized compound with amines proceed, depending on their nature, via substitution of either the F(7) atom or the SMe fragment in the 2-position. The antiviral activity of the obtained 6,7,8-trifluoro-2-ethylthioquinazolin-4-ones was investigated using monkeypox virus, smallpox vaccine, and ectromelia virus. It is shown that fluorinated quinazoline derivatives have good prospects in the search for new active substances Доп.точки доступа: Lipunova, G. N.; Nosova, E. V.; Laeva, A. A.; Charushin, V. N.