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 Найдено в других БД:Каталог книг и продолжающихся изданий (1560)Сводный каталог иностранных периодических изданий, имеющихся в библиотеках УрО РАН (10)Каталог диссертаций и авторефератов диссертаций УрО РАН (185)Каталог препринтов УрО РАН (1975 г. - ) (22)Публикации об УрО РАН (1)Изобретения уральских ученых (1)Интеллектуальная собственность (статьи из периодики) (5)Нанотехнологии (90)Труды Института высокотемпературной электрохимии УрО РАН (195)Труды Института истории и археологии УрО РАН (34)Труды сотрудников Института горного дела УрО РАН (1)Труды сотрудников Института органического синтеза УрО РАН (214)Труды сотрудников Института теплофизики УрО РАН (16)Труды сотрудников Института химии твердого тела УрО РАН (396)Расплавы (848)Публикации Чарушина В.Н. (82)Каталог библиотеки ИГД УрО РАН (1)Каталог библиотеки ИЭРиЖ УрО РАН (44)
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Общее количество найденных документов : 80
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1.
Инвентарный номер: нет.
   


   
    1,3,4-thiadiazine derivates – antioxidants and protein glycation blockers – for correction of experimental diabetes mellitus / V. V. Emelyanov, E. A. Savateeva, L. P. Sidorova [et al.] // Experimental and Computational Biomedicine : Russian conference with international participation in memory of professor Vladimir S. Markhasin. - Ekaterinburg, 2016. - P65
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
1,3,4-THIADIAZINE -- ANTIOXIDANTS -- DIABETES MELLITUS

\\\\Expert2\\NBO\\статьи из сборников\\Experimental and Computational Biomedicine 2016. - P. 65.pdf
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2.
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    2-Thiomorpholino-5-aryl-6 H-1,3,4-thiadiazine hydrobromides and their ability to inhibit nonenzymatic protein glycosylation / L. P. Sidorova, T. A. Tseitler, V. V. Emel’yanov [et al.] // Pharmaceutical Chemistry Journal. - 2017. - Vol. 51, № 1. - P9-12
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
GLYCOSYLATION -- ESTERIFICATION -- GLYCOSYL COMPOUNDS -- DEGLYCOSYLATION -- ?-HALOGENACETOPHENONES -- 1,3,4-THIADIAZINE -- 4-MORPHOLINE THIOSEMICARBAZIDES -- CYCLOCONDENSATION -- NONENZYMATIC PROTEIN GLYCOSYLATION
Аннотация: Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.

\\\\Expert2\\NBO\\Pharmaceutical Chemistry Journal\\2017 v.51 p.9-12.pdf
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3.
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   A 10


   
    A new approach to making autoprostheses for angioplasty / V. A. Chereshnev, B. G. Yushkov, N. V. Tyumentseva [et al.] // Doklady Biological Sciences. - 2006. - Vol. 408, № 1. - P211-213
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANGIOPLASTY -- ANIMAL -- AUTOTRANSPLANTATION

\\\\expert2\\nbo\\Doklady Biological Sciences\\2006. V. 408, N 1.P. 211-213.pdf
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4.
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   A 10


   
    A new experimental model of hemolitic anemia after butoxyethanol and the stady of its immunology / V. A. Chereshnev, P. V. Kosareva, L. V. Sivakova [et al.] // Perm medicine in the context of an international communicftion in science: book of abstracts of the scintific symposium in foreign languages with an international participation. - Perm, 2016. - P30
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNOLOGICAL ACTIVITIES -- IMMUNOLOGY

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5.
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    A rat model of post-traumatic stress syndrome causes phenotype-associated morphological changes and hypofunction of the adrenal gland / V. Tseilikman, M. Komelkova, M. V. Kondashevskaya [et al.] // International journal of molecular sciences. - 2021. - Vol. 22. - Ст. 13235
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CPTSD -- GLUCOCORTICOIDS -- BEHAVIOR -- ADRENAL GLAND

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6.
Инвентарный номер: нет.
   
   A 10


   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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7.
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    Alpha-fetoprotein as a factor of differentiation and functional activity of myeloid-derived suppressor cells / K. Yu. Shardina, S. A. Zamorina, V. P. Timganova [et al.] // Bulletin of experimental biology and medicine. - 2023. - Vol. 175. - P535–543
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: We studied the role of alpha-fetoprotein (AFP) in regulation of differentiation and functional activity of human myeloid-derived suppressor cells (MDSC) in vitro. To obtain MDSC, CD11b+ cells were isolated from the peripheral blood of healthy donors followed by cytokine induction (IL-1β+GM-CSF) into the MDSC phenotype. The cell functions were assessed by the expression of indoleamine 2,3-dioxygenase (IDO) and arginase-1 (Arg1) and cytokine profile of the cell cultures. Native AFP did not affect the total number of MDSC and the percentage of polymorphonuclear MDSC (PMN-MDSC), but increased the number of monocytic MDSC (M-MDSC). AFP did not change the expression of Arg1, but in low concentrations (10 and 50 U/ml) increased the number of IDO-containing cells. AFP modulated the cytokine profile of CD11b+ cells: it reliably decreased the level of IL-19 (50 and100 U/ml) and showed a tendency to decrease the levels of IL-34, MMP-2, sCD163, CHI3L1, OPN and to increase the levels of IL-29, IL-32, APRIL, PTX3, and sTNF-R1. Thus, we have demonstrated a regulatory effect of native AFP at the level of MDSC generated from CD11b+ cells under conditions of cytokine induction in vitro.

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8.
Инвентарный номер: нет.
   
   A 53


   
    An extremal shift method for control of HIV infection dynamics / G. Bocharov, A. V. Kim, A. V. Krasovskii [et al.] // Russian Journal of Numerical Analysis and Mathematical Modelling . - 2015. - Vol. 30, № 1. - P11-25
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HIV INFECTION -- OPTIMAL OPEN-LOOP CONTROL -- EXTREMAL SHIFT METHOD
Аннотация: Optimal control problems for mathematical models describing HIV infection dynamics in a human body are considered in the paper. An overview of current approaches to solution of control problems for models of HIV dynamics is presented for techniques related to construction of optimal programme (open loop) or positional (feedback) controls for various criteria of control process quality and is based on the Pontryagin's maximum principle and the Bellman's theory of dynamic programming, respectively. In the framework of the theory of positional differential games of Krasovskii, there are constructive and efficient methods of synthesis of controls for different classes of dynamical systems. In this paper we present a formalization of a control problem for HIV infection considered as a corresponding positional differential game. The control algorithm based on the method of extremal shift is applied to the ODEs model of HIV infection. The numerical implementation of the extremal shift method is developed to construct the control taking the system to a neighbourhood of a given trajectory using the information on the dynamics of the guides or leaders.

\\\\expert2\\nbo\\Russian Journal of Numerical Anal. and Math. Modelling\\2015. V.30, N. 1. P. 11-30.pdf
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9.
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    Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease : doi.org/10.3390/antib10010009 / I. A. Pashnina, I. M. Krivolapova, T. V. Fedotkina [et al.] // Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9.pdf
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10.
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    Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease / I. A. Pashnina, I. M. Krivolapova, T. V. Fedotkina [et al.] // Preprints. - 2020. - 28 Oct. - Ст. 2020100591. - 27 p.
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Preprints 2020 Ст. 2020100591.pdf
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