Центральная Научная Библиотека УрО РАН

Вид документа : Статья из журнала
Шифр издания : Ч2/R 87
Автор(ы) : Rozental' O. M., Chereshnev V. A.
Заглавие : A normative model of balanced nature management
Место публикации : Russian Journal of Ecology. - 2010. - Vol. 41, № 4. - С. 356-363
Примечания : Bibliogr. : p. 363 (13 ref.)
ББК : Ч2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Ключевые слова (''Своб.индексиров.''): measuring control--traceability--variability of controlled parameters
Аннотация: The risk of erroneous regulation in multilevel normative environmental chains, at the federal, regional, and lower levels, down to the corporate one, has been studied. This risk has been demonstrated to increase unacceptably rapidly in the framework of the existing system of "unconditional acceptance" of normative standards. To mend the situation, it is necessary to use the "conditional acceptance" model by regarding post hoc decisions made at higher levels as a priori ones at the next (lower) levels. A strategy of environmentally and economically balanced corporate regulation of nature management through minimization of the losses resulting from both excessive caution and breaching the existing regulations has been proposed. This system, combined with the European approach to nature conservation, requires that the "riskless" regulation should be abandoned and is expected to improve the parameters of nature management quality by three to four orders of magnitude
\\\\expert2\\NBO\\Russian Journal of Ecology\\2010. V. 41, N 4. P. 356-363.pdf
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 61/I-57
Автор(ы) : Gein S. V., Kuyukina M. S., Ivshina I. B., Chereshnev V. A.
Заглавие : In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: Role of monocyte adhesion
Место публикации : Cytotechnology. - 2011. - Vol. 63, № 6. - С. 559-566
Примечания : Bibliogr. : p. 565-566 (23 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): cytokine-stimulating activity--glycolipid biosurfactant--monocyte adhesion
Аннотация: Glycolipid biosurfactant (GLB) from Rhodococcus ruber IEGM 231 was found to stimulate tumor necrosis factor-α (TNF-α), interleukin (IL) -1β and IL-6 production when applied as an ultrasonic emulsion to the adherent human peripheral blood monocyte culture. However, a lack of cytokine-stimulating activity was registered with the GLB applied as a hydrophobic film coating in 24-well culture plates, indicating that it may have been due to its inhibitory effect on monocyte adhesion. The mode of GLB application may therefore play an important role in in vitro assay of immunostimulatory activity of this compound as well as other bacterial glycolipids. Additionally, GLB from R. ruber displayed no cytotoxicity against human lymphocytes and therefore could be proposed as a potential immunomodulating and antitumor ag
\\\\expert2\\NBO\\Cytotechnology\\2011. V. 63, N 6. P. 559-566.pdf
Найти похожие

Вид документа :
Шифр издания : 57/F 33
Автор(ы) : Bocharov G., Quiel J. B., Luzyanina T., Hadit Alon, Chiglintsev E., Chereshnev V. A., Martin Meier-Schellersheim, William Paul, Zvi Grossman
Заглавие : Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number
Место публикации : Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): parameter estimation--time delay--broxuridine
Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation
\\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf
Найти похожие

Вид документа :
Шифр издания : 61/A 10
Автор(ы) : Bocharov G., Züst R., Cervantes-Barragan L., Luzyanina T., Chiglintsev E., Chereshnev V. A., Volker Thiel, Ludewig B.
Заглавие : A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections.
Место публикации : PLOS pathogens. - 2010. - Vol. 6, № 7. - С. 1-15 : рис., a-табл.
Примечания : Bibliogr. : p. 14-15 (52 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): antivirus agent--dendritic cell--allergy and immunology
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs
\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
Найти похожие

Вид документа :
Шифр издания : 61/C 51
Автор(ы) : Chereshnev V. A., Gusev E. I., Zotova N. V.
Заглавие : [Fundamental-applied aspects of systemic inflammation in terms of physiologic and typical pathological process].
Место публикации : Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk . - 2010. - Vol.96, №7. - С. 696-707
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): pathology--pathophysiology--biological model
Аннотация: The concept of systemic inflammatory response syndrome (SIRS) by sepsis as well as quality of SIRS criteria, classification, and PIRO system has been a subject to analytical criticism in terms of theory of physiologic and typical pathological process. It has been disclosed SIRS can be considered only as the syndrome, that solves particular clinical tasks, but not as a basic model of pathogenesis of critical states. In authors' opinion it is more correctly to discuss systemic inflammation as a typical pathologic process that appears as a complex of one or another "resuscitation" syndrome in a clinical course
Найти похожие

Вид документа :
Шифр издания : 61/C 51
Автор(ы) : Chereshnev V. A., Sosnin D. Yu., Zubareva N. A.
Заглавие : Diagnostic value of studying creatinine in abdominal exudates
Место публикации : Klinichescheskaya Laboratornaya Diagnostika . - 2010. - №3. - С. 11-14
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): creatinine--exudates--renal failure
Аннотация: The levels of creatinine in serum and peritoneal exudate were studied in 77 patients with acute surgical abdominal diseases. It has been found that the exudate concentration of this compound is mainly determined by its level in the serum, which allows the exudate creatinine to be studied for the diagnosis of renal failure. The creatinine concentration in the abdominal exudate in relation to that in the serum varies in urinary tract injury and in the early hours after abdominal sanitation in peritonitis. Exudate creatinine concentration increases (by 2.7-fold or more) require that the urinary tract should be revised to reveal its injury. Creatinine levels in the exudate can be determined not earlier than 8 hours after abdominal lavage. The determination of creatinine concentrations in the peritoneal exudate is a non-invasive and informative tool that enhances the quality of laboratory monitoring in emergency abdominal surgery
Найти похожие

Вид документа :
Шифр издания : 61/C 51
Автор(ы) : Chereshnev V. A., Gein S. V.
Заглавие : Beta-endorphin as the endogenous regulator of immune processes
Место публикации : Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova. - 2009. - Vol. 95, № 12. - С. 1279-1290
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): beta endorphin--opiate receptor--adaptive immunity
Аннотация: Endogenous opioid peptides represent the group of bioregulatory factors possessing a wide range of biologically active effects. One of most essential functions of endogenous opioids appears to be the realization of cellular interaction between nervous and immune systems. Beta-endorphin is a peptide hormone that is the most active and multi-functional representative of the opioid peptide family. This review summarizes current observations on the nature ofbeta-endorphin, its production by the immune system cells, opiate receptor structure and expression, as well as the peptide effect on the processes of cellular activation, proliferation, and differentiation in innate and adaptive immunity
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 57/I-56
Автор(ы) : Deryabin D. G., Sviridova T. G., El'-Registan G. I., Chereshnev V. A.
Заглавие : Impact of bacterial autoregulatory molecules (homoserine lactones and alkylhydroxybenzenes) on the oxidative metabolism of the cell effectors of natural immunity
Место публикации : Microbiology. - 2013. - Vol. 82, № 2. - С. 133-141
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): alkylhydroxybenzenes--chemoluminescence--homoserine lactones
Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations
Найти похожие

Вид документа : Статья из журнала
Шифр издания : 61/N 52
Автор(ы) : Sanakoeva L. P., Koriukina A. D. , Chereshnev V. A., Aksenova V. A.
Заглавие : New capacities of the phagocytic test used in pediatric phthisiology
Место публикации : Probl Tuberk Bolezn Legk . - 2004. - №6. - С. 42-48
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): bcg vaccine--lung tuberculosis--phagocytosis
Аннотация: The paper presents the results of a study of the phagocytic activity of leukocytes (PAL) in 98 healthy children, vaccinated with BCG, in different periods after immunization and in 68 children with tuberculous infection (39 children with tuberculosis and 29 Mycobacterium tuberculosis-infected children). An improved procedure for studying PAL was used, in which sheep erythrocytes of two types ("antigenic" and those with a complex of antigen + antibody + antigen), which may differentiate the phase of bacteremia and immune synthesis, were used as an object for phagocytes. In the limited number of vaccinated children, bacteremia were detectable up to 9 months; the phase of immune synthesis continued in most children up to 3 years. The study has demonstrated that a complex of phagocytic tests may be used for the early diagnosis of tuberculous infection, for the evaluation of a tuberculous process and antituberculous immunity
Найти похожие

10.

Вид документа : Статья из журнала
Шифр издания : 61/T 44
Автор(ы) : Chereshnev V. A., Lushkov B. G., Sumin M. N., Tyumentseva N. V., Khramtsova I. S., Danilova I. G.
Заглавие : The blood system and the organism adaptation to extreme factor
Место публикации : Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk . - 2004. - Vol.90, №10. - С. 1193-1202
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): hemoglobin--hematopoiesis--leukocyte
Аннотация: The formation of blood system adoptive reaction in many cases is defined by the type of action and the condition of hemopoietic inductive microenvironment: hemodynamics of hemopoietic tissue, functional conditions of bone marrow macrophages, mast cells and glycosaminoglycans content. The shift in hemodlobin fraction occurs in extreme conditions requiring an increased gas transport by the blood. In case of tissue lesion, lymphocytes stimulate their regeneration. Morphogenetic function of lymphoid cells may be alerted by immunomodulators. Blood cells participate in angiogenesis, and this property may be used for vessel grafts production
Найти похожие

11.

Вид документа : Статья из журнала
Шифр издания : 61/P 32
Автор(ы) : Chereshnev V. A., Bocharov G., Bazhan S., Bachmetyev B., Gainova I. C., Likhoshvai V.
Заглавие : Pathogenesis and treatment of HIV infection: The cellular, the immune system and the neuroendocrine systems perspective
Место публикации : International Reviews of Immunology. - 2013. - Vol. 32, № 3. - С. 282-306
Примечания : Библиогр.: с. 305- 306 (80 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): disease pathogenesis--effective cure--multiscale model
Аннотация: Infections with HIV represent a great challenge for the development of strategies for an effective cure. The spectrum of diseases associated with HIV ranges from opportunistic infections and cancers to systemic physiological disorders like encephalopathy and neurocognitive impairment. A major progress in controlling HIV infection has been achieved by highly active antiretroviral therapy (HAART). However, HAART does neither eliminate the virus reservoirs in form of latently infected cells nor does it completely reconstitute immune reactivity and physiological status. Furthermore, the failure of the STEP vaccine trial and the only marginal efficacies of the RV144 trial together suggest that the causal relationships between the complex sets of viral and immunological processes that contribute to protection or disease pathogenesis are still poorly understood. Here, we provide an up-to-date overview of HIV-host interactions at the cellular, the immune system and the neuroendocrine systems level. Only by integrating this multi-level knowledge one will be able to handle the systems complexity and develop new methodologies of analysis and prediction for a functional restoration of the immune system and the health of the infected host
Найти похожие

12.

Вид документа : Статья из журнала
Шифр издания : 61/Ч-46
Автор(ы) : Черешнев В. А., Рыбина, Ирина Владимировна, Бейкин, Яков Борисович
Заглавие : Иммунологические и генетические факторы бесплодия у жителей Екатеринбурга
Место публикации : Аллергология и иммунология. - 2006. - Т. 7, № 2. - С. 230-234
Примечания : Библиогр.: с. 234 (22 назв.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): бесплодие--генетические факторы--иммунологические факторы
Аннотация: Investigation of the degree of HLA class I antigens sharing in couples with infertility, testing for anti-spermal antibodies in both partners, anti- phosfolipid and anti-HLA antibodies in women demonstrated the primary role of immunological factors. The chromosomal abnormalities are less important but have to be considered in determination of infertility causes.
\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Аллергология и иммунология\\2006-Vol7-#2_pp230-234.pdf
Найти похожие

13.

Вид документа : Статья из журнала
Шифр издания : Ч2/Ч-46
Автор(ы) : Черешнев В. А., Раев М. Б.
Заглавие : Неинструментальное определение стрептококков группы А
Место публикации : Вестник Уральской медицинской академической науки. - 2008. - № 6. - С. 41-43
Примечания : Библиогр.: с. 43 (15 назв.)
ББК : Ч2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Ключевые слова (''Своб.индексиров.''): стрептококки группы а --диагностика медицинская
Аннотация: The analytical system for the determination of the group-A streptococci (SGA) has been constructed. The designed diag-nosticum does not depend on hardware, i.e. it belongs to the group of so-called non-instrumental systems. The suggested pattern in realized based on the original conjugate (diagnostic reagent) that is synthesized on the basis of covalent binding of polyclonal antibodies against group-A streptococci with colloid carbon particles; this conjugate possesses the ability to bind specifically to appropriate ligand. Due to high absorbance of such conjugates in the visible light region it is possible to make direct visual determination of SGA in a sample under study. The reaction is manifested in a form of black dots on a solid phase working surface. The system could be arranged either in the form of direct determination or in a sandwich-test variant. Such analytical systems could be an efficient tool for dispensary, hospital, and pre-clinical testing including extreme clinical and epidemic situations, as well as these could be applied in different kits for home and field diagnostics
\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Вестник Уральской медицинской академической науки\\2008. № 4. С. 41-43.pdf
Найти похожие

14.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Черешнев В. А., Оникиенко С. Б., Земляной А. В., Абкин С. В.
Заглавие : Применение защитных белков теплового шока-70 для борьбы с COVID-19
Место публикации : Журнал инфектологии. - 2022. - Т. 14, № 2, Приложение 1: Материалы VIII Конгресса Евро-Азиатского общества по инфекционным болезням, Санкт-Петербург, 17-19 мая 2022. - С. 134-135
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): covid 19--коронавирус--шок тепловой--белки защитные
Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations
Найти похожие

15.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shinwari K., Wu Y., Rehman H., Xiao N., Bolkov M., Tuzankina I., Chereshnev V.
Заглавие : In-silico assessment of high-risk non-synonymous SNPs in ADAMTS3 gene associated with Hennekam syndrome and their impact on protein stability and function
Место публикации : BMC Bioinformatics. - 2023. - Vol. 24. - Ст.251
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Hennekam Lymphangiectasia–Lymphedema Syndrome 3 (HKLLS3) is a rare genetical disorder caused by mutations in a few genes including ADAMTS3. It is characterized by lymphatic dysplasia, intestinal lymphangiectasia, severe lymphedema and distinctive facial appearance. Up till now, no extensive studies have been conducted to elucidate the mechanism of the disease caused by various mutations. As a preliminary investigation of HKLLS3, we sorted out the most deleterious nonsynonymous single nucleotide polymorphisms (nsSNPs) that might affect the structure and function of ADAMTS3 protein by using a variety of in silico tools. A total of 919 nsSNPs in the ADAMTS3 gene were identified. 50 nsSNPs were predicted to be deleterious by multiple computational tools. 5 nsSNPs (G298R, C567Y, A370T, C567R and G374S) were found to be the most dangerous and can be associated with the disease as predicted by different bioinformatics tools. Modelling of the protein shows it can be divided into segments 1, 2 and 3, which are connected by short loops. Segment 3 mainly consists of loops without substantial secondary structures. With prediction tools and molecular dynamics simulation, some SNPs were found to significantly destabilize the protein structure and disrupt the secondary structures, especially in segment 2. The deleterious effects of mutations in segment 1 are possibly not from destabilization but from other factors such as the change in phosphorylation as suggested by post-translational modification (PTM) studies. This is the first-ever study of ADAMTS3 gene polymorphism, and the predicted nsSNPs in ADAMST3, some of which have not been reported yet in patients, will serve for diagnostic purposes and further therapeutic implications in Hennekam syndrome, contributing to better diagnosis and treatment.
https://link.springer.com/article/10.1186/s12859-023-05361-6
Найти похожие

16.

Вид документа : Статья из журнала
Шифр издания : 61/A 10
Автор(ы) : Chereshnev V. A., Kosareva P. V., Samodelkin E. I., Sivakova L. V.
Заглавие : A new experimental model of hemolytic anemia after butoxyethanol and the study of its immunology
Место публикации : Hellenic Journal of Nuclear Medicine. - 2014. - January-April. - С. 7-10
Примечания : Bibliogr. : p. 10 (12 ref.)
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): rats - autoimmunity butoxyethanol--hemolytic anemia
Аннотация: 2-butoxyethanol (C6H14O2) is widely used in many industrial reagents; according to the in vitro data it was established that 2- butoxyethanol metabolites are strong haemolytic poisons. Ghanayem B.I., Sullivan Ch.A. (1993) investigated in vitro the effect of BE on the red blood cells of 10 species of mammals, including humans. In this study, the authors established the species specificity with regard to the development of hemolytic anemia under the effect of butoxyethanol [4]. In the context of the available data, creation of experimental model based on the introduction of animal butoxyethanol is taking place. Since the druginduced hemolytic anemia is formed at the adjacency of toxic and autoimmune forms, the study of immunology of any toxic anemia is of great interest. Objective: to develop a new experimental model of hemolytic anemia after butoxyethanol and to study its immunology. In conclusion, the proposed model of hemolytic anemia after butoxyethanol may be used in the experimental and preclinical studies. The intraperitoneal administration of butoxyethanol provokes an autoimmune response directed against own red blood cells. The intraperitoneal administration of butoxyethanol to experimental animals is accompanied by a reduction of the lymphoid tissue that corresponds to the appropriate response to stress in the central and peripheral organs of immunogenesis
\\\\expert2\\nbo\\Hellenic Journal of Nuclear Medicine\\2014. P. 7-10.pdf
Найти похожие

17.

Вид документа : Статья из журнала
Шифр издания : 61/I-34
Автор(ы) : Shinwari K., Chen Z., Liu Guojun, Chen L., Bolkov M. A., Tuzankina I. A., Chereshnev V. A.
Заглавие : Identification of the immune subtype among muscle-invasive bladder cancer patients by multiple datasets
Место публикации : Acta Medica Indonesiana. - 2022. - Vol. 54, № 1. - С. 62-71
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): molecular subtype--immunotherapy--mibc
Аннотация: Background: Immunotherapies including PD-1/PD-L1 antibodies have been approved for the treatment of Muscle-invasive Bladder Cancer (MIBC) patients. However, immunotherapies could only be beneficial for about 20% MIBC patients. Thus, identification of the immune subtype is becoming increasingly important. This study aimed to explore the immune subtype by analyzing the gene expression profiles. Methods: A total of 6 datasets including (GSE13507, GSE31684, GSE32548, GSE32894, GSE69795, and TCGA-BLCA) were downloaded. The gene expression profiles from different datasets were combined since the batch effects were removed. We performed unsupervised clustering analysis to identify the immune subtype by the combined gene expression profiles. The tumor-infiltration levels of 22 immune cells, immune scores, and tumor purity were calculated, and the survival analysis was performed to investigate the prognosis difference between immune subtypes. The enriched pathways for each immune subtype were obtained. Results: We identified four novel immune subtypes (referred to S1, S2, S3, and S4) among MIBC patients. We found that S1 was enriched in immune scores had the best prognosis. In contrast, S3 was poor in immune scores and had the worst prognosis. Subtype S1, S2, S3, and S4 were enriched in immune-related pathways, extracellular matrix-related pathways, metabolism-related pathways, and cancer-related pathways, respectively. Conclusion: The current study suggests that the immune subtypes based on gene expression profiles could contribute to select the appropriate MIBC patient for immunotherapies.
Найти похожие

18.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shinwari K., Liu G., Bolkov M. A., Tuzankina I. A., Chereshnev V. A.
Заглавие : Checking gene expression profile associated with IRF7 and UNC93B deficient patient peripheral blood mononuclear cells infected with pH1N1 influenza virus
Место публикации : AIP Conference Proceedings. - 2022. - Vol. 2390, № 1. - Ст.030089
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): viruses--microarrays--genomics
Аннотация: An innate immune defect is a defect in the innate immune response that reduces the response to infection, this can occurs in genes important for activation regulation and proliferation of the innate immune cells or pathways important for the function of innate immunity. The purpose of this study was to identify novel biomarkers of interferon Receptor 7 through bioinformatics analysis and elucidate the possible molecular mechanism. The GSE 66486 datasets containing microarray data from IRF7 and UNC93B patients and healthy controls were downloaded from the GEO database and analyzed by the GEO2R web tool to obtain different expressed genes (DEGs). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI), and Biological Networks Gene Oncology tool (BiNGO) were then performed to elucidate the molecular mechanism of IRF7. A total of 490 DEGs were identified, of which 14 were hub genes, and involved in ribosome biogenesis, rRNA processing, gene expression, mRNA processing, nuclear lumen, intracellular non-membrane-bounded organelle, nucleoplasm, small-subunit processome, antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes. Antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes possibly form the basis of IRF7 or UNC93B disorders, while our study provides a list of genes and pathways that are disrupted in IRF7/UNC93B, which has the potential to be used in the clinic for diagnosis and targeted therapy of such disorders in future.
Найти похожие

19.

Вид документа : Статья из журнала
Шифр издания : 57/T 84
Автор(ы) : Kuyukina M. S., Ivshina I. B., Baeva T. A., Kochina O. A., Gein S. V., Chereshnev V. A.
Заглавие : Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities
Место публикации : New Biotechnology. - 2015. - V. 32., № 6. - С. 559-568
Примечания : Bibliogr. : p. 566-568 (82 ref.)
ББК : 57
Предметные рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): immunological activities--trehalolipids--rhodococcus rubber
Аннотация: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed.
\\\\expert2\\nbo\\New Biotechnology\\2015. V. 32. N 6. P. 559-568.pdf
Найти похожие

20.

Вид документа : Статья из журнала
Шифр издания : 61/S 98
Автор(ы) : Sidorova L. P., Tseitler T. A., Perova N. M., Emel’yanov V. V., Savateeva E. A., Maksimova N. E., Mochul’skaya N. N., Chereshnev V. A., Chupakhin O. N.
Заглавие : Synthesis of new 1,3,4-thiadiazines capable of inhibiting nonenzymatic glycosylation of proteins
Место публикации : Pharmaceutical Chemistry Journal. - 2015. - Vol. 49, № 8. - С. 501-505
Примечания : Bibliogr. : p. 505 (12 ref.)
ББК : 61 + 54
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): 1,3,4-thiadiazine --cyclocondensation--nonenzymatic glycosylation of proteins--thiosemicarbazides
Аннотация: A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing
\\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2015, 49 (8), 501-505.pdf
Найти похожие

21.

Вид документа : Статья из журнала
Шифр издания : 61/Z 86
Автор(ы) : Zotova N. V., Chereshnev V. A., Gusev E. Yu.
Заглавие : Systemic inflammation: methodological approaches to identification of the common pathological process
Место публикации : PLOS One. - 2016. - Vol. 11, № 5. - С. P. e0155138
ББК : 61
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): multi-syndrome--pathological process
Аннотация: We defined Systemic inflammation (SI) as a “typical, multi-syndrome, phase-specific pathological process, developing from systemic damage and characterized by the total inflammatory reactivity of endotheliocytes, plasma and blood cell factors, connective tissue and, at the final stage, by microcirculatory disorders in vital organs and tissues.” The goal of the work: to determine methodological approaches and particular methodical solutions for the problem of identification of SI as a common pathological process. SI can be defined by the presence in plasma of systemic proinflammatory cell stress products—cytokines and other inflammatory mediators, and also by the complexity of other processes signs. We have developed 2 scales: 1) The Reactivity Level scale (RL)–from 0 to 5 points: 0-normal level; RL-5 confirms systemic nature of inflammatory mediator release, and RL- 2–4 defines different degrees of event probability. 2) The SI scale, considering additional criteria along with RL, addresses more integral criteria of SI: the presence of ≥ 5 points according to the SI scale proves the high probability of SI developing. To calculate the RL scale, concentrations of 4 cytokines (IL-6, IL-8, IL-10, TNF-α) and C-reactive protein in plasma were examined. Additional criteria of the SI scale were the following: D-dimers500ng/ml, cortisol1380 or 100nmol/l, troponin I≥0.2ng/ml and/or myoglobin≥800ng/ml. 422 patients were included in the study with different septic (n-207) and aseptic (n-215) pathologies. In 190 cases (of 422) there were signs of SI (lethality 38.4%, n-73). In only 5 of 78 cases, lethality was not confirmed by the presence of SI. SI was registered in 100% of cases with septic shock (n-31). There were not significant differences between AU-ROC of CR, SI scale and SOFA to predict death in patients with sepsis and trauma.
\\\\expert2\\NBO\\PLoS ONE\\2016, v.11, p. e0155138pdf.pdf
Найти похожие

22.

Вид документа : Статья из журнала
Шифр издания : 50/C 51
Автор(ы) : Chereshnev V. A., Stepanova S. I., Gamburtsev A. G.
Заглавие : Variable polyrhythmicity of processes in nature and society
Место публикации : Herald of the Russian Academy of Sciences. - 2017. - Vol. 87, № 2. - С. 172-180
Примечания : Bibliogr. : p. 180 (15 ref.)
ББК : 50 + 61
Предметные рубрики: ЕСТЕСТВЕННЫЕ НАУКИ-- НАУКА ОБ ОКРУЖАЮЩЕЙ СРЕДЕ-- ЭКОЛОГИЯ В ЦЕЛОМ
ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): variable polyrhythmicity --rhythms in nature and society --time-spectral analysis
Аннотация: The authors discuss possible causes of the variable polyrhythmicity of processes in nature and society, particularly in geophysics. It may be caused by desynchronization or resynchronization of processes that manifest themselves as a result of a shock impact on the geological environment, for example, in the form of an earthquake. Medical parameters are considered for which de- and resynchronization of rhythmic processes in the human organism are known, as well as geophysical processes, including underground noise of tidal origin and the seismicity of the Moon.
\\\\expert2\\NBO\\Herald of the Russian Academy of Sciences\\2017. V. 87, N 2. P. 172-180.pdf
Найти похожие

23.

Вид документа : Статья из журнала
Шифр издания : 54
Автор(ы) : Sidorova L. P., Tseitler T. A., Emel’yanov V. V., Savateeva E. A., Maksimova N. E., Mochul’skaya N. N., Chereshnev V. A., Chupakhin O. N.
Заглавие : 2-Thiomorpholino-5-aryl-6 H-1,3,4-thiadiazine hydrobromides and their ability to inhibit nonenzymatic protein glycosylation
Место публикации : Pharmaceutical Chemistry Journal. - 2017. - Vol. 51, № 1. - С. 9-12
ББК : 54
Предметные рубрики: ХИМИЧЕСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): glycosylation--esterification--glycosyl compounds--deglycosylation--?-halogenacetophenones--1,3,4-thiadiazine--4-morpholine thiosemicarbazides--cyclocondensation--nonenzymatic protein glycosylation
Аннотация: Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.
\\\\Expert2\\NBO\\Pharmaceutical Chemistry Journal\\2017 v.51 p.9-12.pdf
Найти похожие

24.

Вид документа : Статья из журнала
Шифр издания : 001.2/C 51
Автор(ы) : Chereshnev V. A., Gamburtsev A. G., Stepanova S. I.
Заглавие : Synchronization, desynchronization, and resynchronization as mechanisms for the formation of variable polyrhythmicity in biological and geophysical systems
Место публикации : Doklady Earth Sciences. - 2017. - Vol. 472, № 1. - С. 123-125
ББК : 001.2
Предметные рубрики: НАУКА. НАУКОВЕДЕНИЕ
Аннотация: The variable polyrhythmicity observed in natural, technical, and humanitarian spheres can be the result of mutual desynchronization of conjugate rhythmic processes. One example of desynchronization in medicine is fibrillations of heart ventricles. To bring a patient out of this state, electroshock is applied, which frequently leads to defibrillation and recovery of normal heart rhythm (resynchronization). This phenomenon has analogies in other fields of science. It is known that lunar–solar tides cause subsurface seismic noise. We give an example of detecting such noise in the Ashkhabad seismic survey area. This noise can appear and disappear, and the reason may be certain shock impacts, in particular, earthquakes. Similar results have been obtained in studying lunar seismicity, where tidal phenomena are more strongly pronounced than on Earth.
\\\\Expert2\\NBO\\Doklady Earth Sciences\\2017 v. 474 p. 126-128.pdf
Найти похожие

25.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pashnina I. A., Krivolapova I. M., Fedotkina T. V., Ryabkova V. A., Chereshneva M. V., Churilov L. P., Chereshnev V. A.
Заглавие : Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease
Место публикации : Preprints. - 2020. - 28 Oct. - Ст.2020100591. - С. 27 p.
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.
\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Preprints 2020 Ст. 2020100591.pdf
Найти похожие

26.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Pashnina I. A., Krivolapova I. M., Fedotkina T. V., Ryabkova V. A., Chereshneva M. V., Churilov L. P., Chereshnev V. A.
Заглавие : Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease : doi.org/10.3390/antib10010009
Место публикации : Antibodies. - 2021. - Vol. 10, № 1. - Ст.9
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.
\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9.pdf
Найти похожие

27.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shinwari K., Rehman H., Liu Guojun, Bolkov M. A., Tuzankina I. A., Chereshnev V. A.
Заглавие : Novel disease-associated missense single-nucleotide polymorphisms variants predication by algorithms tools and molecular dynamics simulation of human TCIRG1 gene causing congenital neutropenia and osteopetrosis
Место публикации : Frontiers in Molecular Biosciences. - 2022. - Vol. 9. - Ст.879875
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: T Cell Immune Regulator 1, ATPase H + Transporting V0 Subunit A3 (TCIRG1 gene provides instructions for making one part, the a3 subunit, of a large protein complex known as a vacuolar H + -ATPase (V-ATPase). V-ATPases are a group of similar complexes that act as pumps to move positively charged hydrogen atoms (protons) across membranes. Single amino acid changes in highly conserved areas of the TCIRG1 protein have been linked to autosomal recessive osteopetrosis and severe congenital neutropenia. We used multiple computational approaches to classify disease-prone single nucleotide polymorphisms (SNPs) in TCIRG1. We used molecular dynamics analysis to identify the deleterious nsSNPs, build mutant protein structures, and assess the impact of mutation. Our results show that fifteen nsSNPs (rs199902030, rs200149541, rs372499913, rs267605221, rs374941368, rs375717418, rs80008675, rs149792489, rs116675104, rs121908250, rs121908251, rs121908251, rs149792489 and rs116675104) variants are likely to be highly deleterious mutations as by incorporating them into wild protein they destabilize the wild protein structure and function. They are also located in the V-ATPase I domain, which may destabilize the structure and impair TCIRG1 protein activation, as well as reduce its ATPase effectiveness. These mutants have not yet been identified in patients suffering from CN and osteopetrosis while (G405R, R444L, and D517N) reported in our study are already associated with osteopetrosis. Mutation V52L reported in our study was identified in a patient suspected for CN. Finally, these mutants can help to further understand the broad pool of illness susceptibilities associated with TCIRG1 catalytic kinase domain activation and aid in the development of an effective treatment for associated diseases.
Найти похожие

28.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Saidakova E. V., Korolevskaya L. B., Shmagel N. G., Vlasova V. V., Shardina K. Yu., Chereshnev V. A., Shmagel K. V.
Заглавие : In HIV-infected immunological non-responders, hepatitis C virus eradication contributes to incomplete normalization of systemic inflammation, but does not lead to rapid CD4+ T-cell count recovery
Место публикации : Doklady Biochemistry and Biophysics. - 2023. - Vol. 512. - С. 274–278
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Ключевые слова (''Своб.индексиров.''): hiv infections--hepatitis c--immunological non-response
Аннотация: In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases systemic inflammation, which interferes with the CD4+ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4+ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called “immunological non-responders” (INRs). HIV-infected patients who received a course of direct-acting antivirals for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected INRs and relatively healthy volunteers. It was established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4+/CD8+ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete.
Найти похожие

29.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Sobolevskaya P. A., Gvozdeckii A. N., Kudryavtsev I. V., Chereshnev V. A., Сhurilov L. P.
Заглавие : Role of proinflammatory cytokines in hashimoto's thyroiditis associated with psychiatric disorders
Место публикации : Medical Immunology. - 2023. - Vol. 25, № 5. - С. 1247-1252
Предметные рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Mental disorders often accompany autoimmune diseases, for example, since 1949 it has been known about “myxedematous madness”, a psychosis caused by hypothyroidism. The most common cause of hypothyroidism is Hashimoto's autoimmune thyroiditis. It is also known about another neuropsychiatric disorder associated with autoimmune thyroiditis, Hashimoto's encephalopathy. It is a severe dysfunction of the central nervous system, the pathogenesis of which is not associated with hormonal disorders. Cytokines are regulators and participants of inflammation, including autoimmune. Certainly, when we are talking about high concentrations cytokines, we mean systemic inflammation. The minimal or mediocre fluctuations in cytokines within the ranges that are characteristic of healthy status or normergic acute phase response in disease cannot be interpreted from the point of view of binary endocrinological logic. In the CNS, cytokines are able to influence on the neuroendocrine control of systemically regulated functions. It is also important that glial cells (astroglia, microglia) are capable of producing a number of cytokines and can affect neurons and develop behavioral changes. In addition, the ability of a number of cytokines outside the CNS itself to act on vagal afferents and through them to convey information to the CNS, affecting its state and functions, has been proven. It is reasonable to assume that minimal fluctuations in cytokine levels may also affect the state and function of the CNS. The aim of the study was to investigate the levels of cytokines in patients with thyroiditis; in patients with thyroiditis associated with mental disorders; in a group of healthy individuals; and evaluate the effect of cytokine levels on clinical manifestations. In the group of patients with thyroiditis and mental disorders, the levels of CCL20/MIP3α, IL-13, IL-2, IL-27, IL-5 were significantly higher than in other groups. At the same time, no positive correlation was found between the clinical manifestations of mental disorders and the levels of cytokines. A positive correlation was found between the levels of some cytokines and free triiodothyronine, as well as the level of antithyroid antibodies. Mental disorders associated with autoimmune thyroiditis may be associated with changes in the cytokine profile and result from neuroinflammation.
Найти похожие

Сиглы отделов ЦНБ УрО РАН

  бр.ф. - Бронированный фонд

  бф - Научно-библиографический отдел

  БХЛ - Фонд художественной литературы

  ИИиА -Фонд исторической литературы в ЦНБ УрО РАН

  ИМЕТ -Отдел ЦНБ в Институте металлургии УрО РАН

  кх - Отдел фондов (книгохранениe)

  МБА - Межбиблиотечный абонемент

  мф - Методический фонд

  ок - Отдел научной каталогизации

  оку - Отдел комплектования и учета

  орф - Обменно-резервный фонд

  пф - Читальный зал деловой и патентной информации

  рк - Фонд редкой книги

  ч/з - Главный читальный зал

  эр - Зал электронных ресурсов

Сиглы библиотек институтов и НЦ УрО РАН

© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)