Центральная Научная Библиотека УрО РАН

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    Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes / Zihao Chen, Guojun Liu, Guoqing Liu [et al.]. - https://doi.org/10.1186/s41065-020-00165-7 // Hereditas. - 2021. - Vol. 158, № 1. - 12 p
Кл.слова (ненормированные):
CD8+ T CELLS -- MOLECULAR SUBTYPE -- IMMUNOTHERAPY
Аннотация: Immunotherapy, especially anti-PD-1, is becoming a pillar of modern muscle-invasive bladder cancer (MIBC) treatment. However, the objective response rates (ORR) are relatively low due to the lack of precise biomarkers to select patients. Herein, the molecular subtype, tumor mutation burden (TMB), and CD8+ T cells were calculated by the gene expression and mutation profiles of MIBC patients. MIBC immunotypes were constructed using clustering analysis based on tumor mutation burden, CD8+ T cells, and molecular subtypes. Mutated genes, enriched functional KEGG pathways and GO terms, and co-expressed network-specific hub genes have been identified. We demonstrated that ORR of immunotype A patients identified by molecular subtype, CD8+ T cells, and TMB is about 36% predictable. PIK3CA, RB1, FGFR3, KMT2C, MACF1, RYR2, and EP300 are differentially mutated among three immunotypes. Pathways such as ECM-receptor interaction, PI3K-Akt signaling pathway, and TGF-beta signaling pathway are top-ranked in enrichment analysis. Low expression of ACTA2 was associated with the MIBC survival benefit. The current study constructs a model that could identify suitable MIBC patients for immunotherapy, and it is an important step forward to the personalized treatment of bladder cancers.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Hereditas. - 2021. - Vol. 158, № 1.pdf
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   E 20


    Ecologically stimulated secondary immune deficiencies / V. A. Chereshnev, N. N. Kevorkov, B. A. Bachmetyev, Ju. I. Shilov, S. V. Shirshev, M. B. Rayev // The 1995 International Co-Conferences on Environmental Pollution (ICEP`95) and Neuroimmuno Interactions and Environment (ICONE`95). - Saint Petersburg, 1995. - P102

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNE DEFICIENCIES

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   K 42

    Khaustov, V. P.
    Arrangement of environment control activity at Lipetsk iron and steel works / V. P. Khaustov, V. A. Chereshnev // Steel in Translation. - 1993. - № 11. - P86-90

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Аннотация: Recently different co-operative and small enterprises in utilization of slag spent materials reprocessing and utilization of oil wastes from rolling mills, development and implantation of new non-conventional gas-and-dust precipitators have been established and successfully operated. Due to different measures of all services and shops in the last three years negative effect upon environment has been decreased considerably. Harmful exhausts to atmosphere were decreased by 136 thous. of tons, sewage effluency was reduced by 5.3 mln.m3, 95% of wastes are utilized

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   M 85

    Morova, A. A.
    Human endoecology and diseases occurrence / A. A. Morova, V. A. Chereshnev // The 1995 International Co-Conferences on Environmental Pollution (ICEP`95) and Neuroimmuno Interactions and Environment (ICONE`95). - Saint Petersburg, 1995. - P153

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
DISEASES OCCURRENCE

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   R 30


    Reaction diffusion modelling of interferon distribution in secondary lymphoid organs / G. Bocharov, A. Danilov, Y. Vassilevski [et al.] // Mathematical modelling of natural phenomena. - 2011. - Vol. 6, № 7. - P13-26

ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
SYSTEMS -- RECIRCULATION -- LYMPHOCYTES
Аннотация: This paper proposes a quantitative model of the reaction-diffusion type to examine the distribution of interferon-alpha (IFN alpha) in a lymph node (LN). The numerical treatment of the model is based on using an original unstructured mesh generation software Ani3D and nonlinear finite volume method for diffusion equations. The study results in suggestion that due to the variations in hydraulic conductivity of various zones of the secondary lymphoid organs the spatial stationary distribution of IFN alpha is essentially heterogeneous across the organs. Highly protected domains such as sinuses, conduits, co-exist with the regions in which where the stationary concentration of IFN alpha is lower by about 100-fold. This is the first study where the spatial distribution of soluble immune factors in secondary lymphoid organs is modelled for a realistic three-dimensional geometry

\\\\expert2\\nbo\\Mathematical Modelling and Natural Phenomena\\2011. Vol.6, №7. С. 13-26.pdf
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   R 45


    Research priorities for HIV/M. tuberculosis co-infection [Text] / M. A. Alvarez, Patricia Arbelae, Francisko Ignacio Bastos [et al.] // Open Infectious Diseases Journal. - 2011. - Vol. 5, № 1. - P14-20. - Bibliogr. : p. 19-20 (40 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
AIDS/TB -- PRIORITY AREAS -- JOINT
Аннотация: This document summarizes priority areas for joint research and concerted actions to counteract the public health threat of AIDS/TB as identified within the European Support Action "EUCO-Net" funded under the 7th Framework Programme of the European Commission

\\\\expert2\\nbo\\The Open Infectious Diseases Journal\\2011. - Vol.5, №1. - С. 14-20.pdf
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