Modulation of Cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus Biosurfactant / V. A. Chereshnev, S. V. Gein, T. A. Baeva [et al.] // Bulletin of experimental biology and medicine. - 2010. - Vol. 149, № 6. - P734-738 Кл.слова (ненормированные): RHODOCOCCUS RUBBEr -- GLYCOLIPID BIOSURFACTANT -- INTERLEUKIN-10 Аннотация: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2010, v.149, N 6, p. 734-738.pdf |
I-57 In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber / M. S. Kuyukina, I. B. Ivshina, S. V. Gein, V. A. Chereshnev // Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 5. - P326-330 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ACTINOBACTERIA -- RHODOCOCCUS RUBER -- BIOSURFACTANT Аннотация: The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1 beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1 beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug \\\\Expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2007, v.144, N 3, p. 326.pdf |
I-57 In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: Role of monocyte adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina, V. A. Chereshnev // Cytotechnology. - 2011. - Vol. 63, № 6. - P559-566. - Bibliogr. : p. 565-566 (23 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): CYTOKINE-STIMULATING ACTIVITY -- GLYCOLIPID BIOSURFACTANT -- MONOCYTE ADHESION Аннотация: Glycolipid biosurfactant (GLB) from Rhodococcus ruber IEGM 231 was found to stimulate tumor necrosis factor-α (TNF-α), interleukin (IL) -1β and IL-6 production when applied as an ultrasonic emulsion to the adherent human peripheral blood monocyte culture. However, a lack of cytokine-stimulating activity was registered with the GLB applied as a hydrophobic film coating in 24-well culture plates, indicating that it may have been due to its inhibitory effect on monocyte adhesion. The mode of GLB application may therefore play an important role in in vitro assay of immunostimulatory activity of this compound as well as other bacterial glycolipids. Additionally, GLB from R. ruber displayed no cytotoxicity against human lymphocytes and therefore could be proposed as a potential immunomodulating and antitumor ag \\\\expert2\\NBO\\Cytotechnology\\2011. V. 63, N 6. P. 559-566.pdf |
В 58 Влияние биосурфактантного гликолипидного комплекса R. RUBER ИЕГМ 231 на секреторную активность эффекторов врожденного иммунитета / С. В. Гейн, Т. А. Баева, М. Куюкина, И. Б. Ившина, В. А. Черешнев // Вестник Уральской медицинской академической науки. - 2008. - № 4. - С. 48-51. - Библиогр.: с. 50 (12 назв.) Рубрики: НАУКА. НАУКОВЕДЕНИЕ Кл.слова (ненормированные): R. RUBER -- ИЕГМ 231 -- ВРОЖДЕННЫЙ ИММУНИТЕТ Аннотация: It is shown that in monocyte fraction the biosurfactant glycolipid complex of R. ruber IEGM 231 promotes the pro duction of IL-1β and TNF-α cytokines while unaffecting the IL-6 synthesis. The glycolipid biosurfactant effect on IL-1β, TNF-α, and IL-6 synthesis was not registered in mononuclear fraction. In neutrophil fraction the preparation was found to enhance the IL-8 production and did not change the IL-lβ and TNF-α secretion. The results obtained indicate the availability of further research of immune modulating and antitumor activity of biosurfactant preparation. \\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Вестник Уральской медицинской академической науки\\2008. № 4. С. 48-51.pdf |
I-57 In vitro immunomodulating properties of biosurfactant glicolipid complex in the rhodococcus rubber. The role of monocyte and cell adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina [et al.] // Environmental pollution, adaptation, immunity : abstracts VII International Conference. - Perm, 2008. - P147 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNOMODULATING PROPERTIES -- GLICOLIPID COMPLEX -- MONOCYTES |
E 27 Effect of glycolipid Rhodococcus biosurfactant on secretory activity of neutrophils in vitro / T. A. Baeva, S. V. Gein, M. S. Kuyukina [et al.] // Bulletin of experimental biology and medicine. - 2014. - Vol. 157, № 2. - P238-242. - Bibliogr. : p. 242 (15 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): GLYCOLIPID -- RHODOCOCCUS RUBER -- NEUTROPHILS Аннотация: Glycolipid biosurfactant synthesized by nonpathogenic strain Rhodococcus ruber IEGM231 modulated the production of ROS and IL-8 by peripheral blood neutrophils in spontaneous and stimulated cultures. Secretion of IL-1β и TNF-α by neutrophils in the presence of biosurfactant changed insignifi cantly \\\\expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2014, v.157, N 2, p. 238-242.pdf |
I-57 In vivo immuno regulatory effects of Rhodococcus biosurfactant at different administration modes / O. A. Kochina, S. V. Gein, M. S. Kuyukina [et al.] // Microbial Diversity: Resource Potential – ICOMID 2016 : proceedings of the IV international conference. - Moscow, 2016. - P127 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ \\\\Expert2\\NBO\\статьи из сборников\\Kochina icomid 2016.pdf |