R 30 Reaction diffusion modelling of interferon distribution in secondary lymphoid organs / G. Bocharov, A. Danilov, Y. Vassilevski [et al.] // Mathematical modelling of natural phenomena. - 2011. - Vol. 6, № 7. - P13-26 Рубрики: НАУКА. НАУКОВЕДЕНИЕ Кл.слова (ненормированные): SYSTEMS -- RECIRCULATION -- LYMPHOCYTES Аннотация: This paper proposes a quantitative model of the reaction-diffusion type to examine the distribution of interferon-alpha (IFN alpha) in a lymph node (LN). The numerical treatment of the model is based on using an original unstructured mesh generation software Ani3D and nonlinear finite volume method for diffusion equations. The study results in suggestion that due to the variations in hydraulic conductivity of various zones of the secondary lymphoid organs the spatial stationary distribution of IFN alpha is essentially heterogeneous across the organs. Highly protected domains such as sinuses, conduits, co-exist with the regions in which where the stationary concentration of IFN alpha is lower by about 100-fold. This is the first study where the spatial distribution of soluble immune factors in secondary lymphoid organs is modelled for a realistic three-dimensional geometry \\\\expert2\\nbo\\Mathematical Modelling and Natural Phenomena\\2011. Vol.6, №7. С. 13-26.pdf |
I-60 Inflammation markers in atherosclerosis development / A. P. Shavrin, Y. V. Khovaeva, V. A. Chereshnev, B. V. Golovskoy // Cardiovascular therapy and prevention. - 2009. - Vol. 8, № 3. - P13-15 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): CONGESTIVE-HEART-FAILURE -- TUMOR-NECROSIS-FACTOR -- DEPENDENT VASODILATION Аннотация: To study different inflammation markers at various stages of atherosclerosis progression. Material and methods. In 174 21-70-year-old people, brachial artery ultrasound (Aloka 5000) was performed to Visualize atherosclerotic plaques and assess intima-media thickness (IMT). Immuno-enzyme analysis was used to measure plasma levels of C-reactive protein, CRP (SeroELISA test system, Diagnostic Systems Laboratories, USA), and cytokines - tumor necrosis factor alpha (THF-alpha), interleukins 1, 4 and 8 (1L-1, 2, and 8) (Russian test systems, Cytokine company, St. Petersburg |
H 91 Human immunodeficiency virus infection: From biological observations to mechanistic mathematical modelling / G. Bocharov, V. A. Chereshnev, I. C. Gainova [et al.] // Mathematical modelling of natural phenomena. - 2012. - Vol. 7, № 5. - P78-104. - Bibliogr. : p. 93-104 (275 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): HOST-PATHOGEN INTERACTION -- IMMUNE SYSTEM -- HUMAN IMMUNODEFICIENCY Аннотация: HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to 'dynamic' categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis \\\\expert2\\NBO\\Mathematical Modelling and Natural Phenomena\\2012. V. 7, N 5. P. 78-104.pdf |
A 10 A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs \\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf |
C 51 Chereshnev, V. A. Beta-endorphin as the endogenous regulator of immune processes / V. A. Chereshnev, S. V. Gein // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova. - 2009. - Vol. 95, № 12. - P1279-1290 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): BETA ENDORPHIN -- OPIATE RECEPTOR -- ADAPTIVE IMMUNITY Аннотация: Endogenous opioid peptides represent the group of bioregulatory factors possessing a wide range of biologically active effects. One of most essential functions of endogenous opioids appears to be the realization of cellular interaction between nervous and immune systems. Beta-endorphin is a peptide hormone that is the most active and multi-functional representative of the opioid peptide family. This review summarizes current observations on the nature ofbeta-endorphin, its production by the immune system cells, opiate receptor structure and expression, as well as the peptide effect on the processes of cellular activation, proliferation, and differentiation in innate and adaptive immunity |
М 27 Маркеры воспаления в процессе развития атеросклероза [] / А. П. Шаврин, Я. Б. Ховаева, В. А. Черешнев, Б. В. Головской // Кардиоваскулярная терапия и профилактика. - 2009. - Т. 8, № 3. - С. 13-15. - Библиогр.: с. 15 (12 назв.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): АТЕРОСКЛЕРОЗ -- ВОСПАЛЕНИЕ -- ЦИТОКИНЫ Аннотация: Цель. Изучить показатели воспалительного процесса на разных стадиях развития атеросклероза. Материал и методы. У 174 человек в возрасте 21-70 лет выполнено ультразвуковое сканирование брахеоцефальных сосудов на аппарате АЛОКА 5000, для визуализации атеросклеротических бляшек и определения толщины комплекса интима-медиа (КИМ). Методом иммуноферментного анализа (ИФА) в плазме крови определяли количественное содержание С-реактивного белка (CРБ) тест-системой SeroELISA фирмы Diagnostic Systems Laboratories (США), и цитокинов с помощью отечественных тест-систем (ООО Цитокин, СПб): фактор некроза опухолей (ФНОα), интерлейкин-1 (ИЛ-1), ИЛ-4 и ИЛ-8. Результаты. Содержание СРБ и провоспалительных цитокинов ИЛ-1, ИЛ-8, ФНОα зависит от стадии атеросклеротического процесса, степени увеличения толщины КИМ. Увеличение концентрации СРБ до уровня, характеризующего системную воспалительную реакцию, отмечено у лиц с субклиническим течением атеросклероза и у пациентов с постинфарктным кардиосклерозом. Заключение. Существует взаимосвязь между толщиной сосудистой стенки и выраженностью латентного воспалительного процесса, причем качественные изменения в интенсивности воспалительного процесса имеют место на начальных этапах формирования атеросклероза |
I-56 Impact of bacterial autoregulatory molecules (homoserine lactones and alkylhydroxybenzenes) on the oxidative metabolism of the cell effectors of natural immunity / D. G. Deryabin, T. G. Sviridova, G. I. El'-Registan, V. A. Chereshnev // Microbiology. - 2013. - Vol. 82, № 2. - P133-141 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ALKYLHYDROXYBENZENES -- CHEMOLUMINESCENCE -- HOMOSERINE LACTONES Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations |
A 87 Aspiration system for cast houses / E. V. Nevmerzhitskii, V. P. Churkin, V. I. Pleshkov, A. A. Meshcheryakov, V. A. Chereshnev // Metallurgist. - 1990. - Vol. 34, № 2. - P34-35 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): AIR POLLUTION - CONTROL -- CYCLONES -- GAS PURIFICATION Аннотация: Suction systems remove dust and gases from the slag discharge areas of the blast furnaces at the Movolipetsk Metallurgical Combine. The aspiration system of one furnace operates in two regimes and the gases are subjected to single-stage cleaning in a sprayed cyclone-type shaft. Dust removal efficiency is 90%. The suctioned air from the other furnace is cleaned of charge materials in battery cyclones and a sprayed cyclone-type shaft. Cleaning efficiency is 90-93%. |
P 32 Pathogenesis and treatment of HIV infection: The cellular, the immune system and the neuroendocrine systems perspective / V. A. Chereshnev, G. Bocharov, S. Bazhan [et al.] // International Reviews of Immunology. - 2013. - Vol. 32, № 3. - P282-306. - Библиогр.: с. 305- 306 (80 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): DISEASE PATHOGENESIS -- EFFECTIVE CURE -- MULTISCALE MODEl Аннотация: Infections with HIV represent a great challenge for the development of strategies for an effective cure. The spectrum of diseases associated with HIV ranges from opportunistic infections and cancers to systemic physiological disorders like encephalopathy and neurocognitive impairment. A major progress in controlling HIV infection has been achieved by highly active antiretroviral therapy (HAART). However, HAART does neither eliminate the virus reservoirs in form of latently infected cells nor does it completely reconstitute immune reactivity and physiological status. Furthermore, the failure of the STEP vaccine trial and the only marginal efficacies of the RV144 trial together suggest that the causal relationships between the complex sets of viral and immunological processes that contribute to protection or disease pathogenesis are still poorly understood. Here, we provide an up-to-date overview of HIV-host interactions at the cellular, the immune system and the neuroendocrine systems level. Only by integrating this multi-level knowledge one will be able to handle the systems complexity and develop new methodologies of analysis and prediction for a functional restoration of the immune system and the health of the infected host |
Ч-46 Черешнев, В. А. Неинструментальное определение стрептококков группы А / В. А. Черешнев, М. Б. Раев // Вестник Уральской медицинской академической науки. - 2008. - № 6. - С. 41-43. - Библиогр.: с. 43 (15 назв.) Рубрики: НАУКА. НАУКОВЕДЕНИЕ Кл.слова (ненормированные): СТРЕПТОКОККИ ГРУППЫ А -- ДИАГНОСТИКА МЕДИЦИНСКАЯ Аннотация: The analytical system for the determination of the group-A streptococci (SGA) has been constructed. The designed diag-nosticum does not depend on hardware, i.e. it belongs to the group of so-called non-instrumental systems. The suggested pattern in realized based on the original conjugate (diagnostic reagent) that is synthesized on the basis of covalent binding of polyclonal antibodies against group-A streptococci with colloid carbon particles; this conjugate possesses the ability to bind specifically to appropriate ligand. Due to high absorbance of such conjugates in the visible light region it is possible to make direct visual determination of SGA in a sample under study. The reaction is manifested in a form of black dots on a solid phase working surface. The system could be arranged either in the form of direct determination or in a sandwich-test variant. Such analytical systems could be an efficient tool for dispensary, hospital, and pre-clinical testing including extreme clinical and epidemic situations, as well as these could be applied in different kits for home and field diagnostics \\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Вестник Уральской медицинской академической науки\\2008. № 4. С. 41-43.pdf |
C 51 Chereshnev, V. A. Systems methodologines for underssytanding the pathogenesis of virus infections / V. A. Chereshnev, G. A. Bocharov, E. V. Karamov // International Immunology. - 2010. - Vol. 22, № 1 : XIVth International Congress of Immunoiogy, Kobe, Japan, August 22-27 2010. - С. iv123 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNE SYSTEM -- VIRUS INFECTIONS |
Применение защитных белков теплового шока-70 для борьбы с COVID-19 / В. А. Черешнев, С. Б. Оникиенко, А. В. Земляной, С. В. Абкин // Журнал инфектологии. - 2022. - Т. 14, № 2, Приложение 1 : Материалы VIII Конгресса Евро-Азиатского общества по инфекционным болезням, Санкт-Петербург, 17-19 мая 2022. - С. 134-135 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): COVID 19 -- КОРОНАВИРУС -- ШОК ТЕПЛОВОЙ -- БЕЛКИ ЗАЩИТНЫЕ Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations |
T 23 Tat-rev regulation of HIV-1 replication: mathematical model predicts the existence of oscillatory dynamics / V. Likhoshvai, T. Khlebodarova, S. Bazhan, I. A. Gainova, V. A. Chereshnev, G. Bocharov // The Ninth International conference on Bionformatics of Genome Regulation and Structure\Systems Biology. Novosibirsk, June 23–28 2014: abstracts. - Novosibirsk, 2014. - P. 101-102 Рубрики: НАУКА. НАУКОВЕДЕНИЕ Кл.слова (ненормированные): MATHEMATICAL MODELS -- OSCILLATORY DYNAMICS -- HIV-1 REPLICATION |
A 53 An extremal shift method for control of HIV infection dynamics / G. Bocharov, A. V. Kim, A. V. Krasovskii [et al.] // Russian Journal of Numerical Analysis and Mathematical Modelling . - 2015. - Vol. 30, № 1. - P11-25 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): HIV INFECTION -- OPTIMAL OPEN-LOOP CONTROL -- EXTREMAL SHIFT METHOD Аннотация: Optimal control problems for mathematical models describing HIV infection dynamics in a human body are considered in the paper. An overview of current approaches to solution of control problems for models of HIV dynamics is presented for techniques related to construction of optimal programme (open loop) or positional (feedback) controls for various criteria of control process quality and is based on the Pontryagin's maximum principle and the Bellman's theory of dynamic programming, respectively. In the framework of the theory of positional differential games of Krasovskii, there are constructive and efficient methods of synthesis of controls for different classes of dynamical systems. In this paper we present a formalization of a control problem for HIV infection considered as a corresponding positional differential game. The control algorithm based on the method of extremal shift is applied to the ODEs model of HIV infection. The numerical implementation of the extremal shift method is developed to construct the control taking the system to a neighbourhood of a given trajectory using the information on the dynamics of the guides or leaders. \\\\expert2\\nbo\\Russian Journal of Numerical Anal. and Math. Modelling\\2015. V.30, N. 1. P. 11-30.pdf |
C 51 Chereshnev, V. A. Synchronization, desynchronization, and resynchronization as mechanisms for the formation of variable polyrhythmicity in biological and geophysical systems / V. A. Chereshnev, A. G. Gamburtsev , S. I. Stepanova // Doklady Earth Sciences. - 2017. - Vol. 472, № 1. - P123-125 Рубрики: НАУКА. НАУКОВЕДЕНИЕ Аннотация: The variable polyrhythmicity observed in natural, technical, and humanitarian spheres can be the result of mutual desynchronization of conjugate rhythmic processes. One example of desynchronization in medicine is fibrillations of heart ventricles. To bring a patient out of this state, electroshock is applied, which frequently leads to defibrillation and recovery of normal heart rhythm (resynchronization). This phenomenon has analogies in other fields of science. It is known that lunar–solar tides cause subsurface seismic noise. We give an example of detecting such noise in the Ashkhabad seismic survey area. This noise can appear and disappear, and the reason may be certain shock impacts, in particular, earthquakes. Similar results have been obtained in studying lunar seismicity, where tidal phenomena are more strongly pronounced than on Earth. \\\\Expert2\\NBO\\Doklady Earth Sciences\\2017 v. 474 p. 126-128.pdf |
Problems of pathogenesis and pathogenetic therapy of COVID-19 from the perspective of the General theory of pathological systems (General pathological processes) / E. Gusev, A. Sarapultsev, H. Desheng, V. A. Chereshnev // International journal of molecular sciences. - 2021. - Vol. 22, № 14. - Ст. 7582 (32 pp.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): COVID 19 -- КОРОНАВИРУС \\\\nas3\\Nbo\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\International journal of molecular sciences. - 2021. - Vol. 22, № 14. - Ст. 7582 (32 pp.).pdf |