Инвентарный номер: нет.        П 71         Премия имени И. И. Мечникова 2002 года - В. А. Черешневу и О. В. Бухарину [] // Вестник Российской академии наук. - 2002. - Т. 72, № 10. - С. 958 : фот. . - ISSN 0869-5873ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ПРЕМИИ -- ЛАУРЕАТЫ -- ПРЕМИЯ ИМЕНИ И. И. МЕЧНИКОВА -- АДАПТАЦИЯ БИОЛОГИЧЕСКАЯ -- СИМБИОЗ -- ПАРАЗИТ-ХОЗЯИН (СИСТЕМА) -- СИСТЕМА "ПАРАЗИТ-ХОЗЯИН" Аннотация: За цикл работ "Адаптивные стратегии взаимодействия симбионтов в системе "паразит-хозяин""

Инвентарный номер: нет.        Ю 96     Юшков, Б. Г.     К истории физиологической науки в Екатеринбурге: события, даты, имена [] / Б. Г. Юшков // Наука Урала. - 2004. - № 21. - С. 7 : фот. ББК 57 + 28 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ФИЗИОЛОГИЯ ЧЕЛОВЕКА -- ИММУНОФИЗИОЛОГИЯ -- СОСУДЫ -- АУТОПРОТЕЗЫ СОСУДОВ Аннотация: Упоминаются новые направления в физиологии, развиваемые академиком В. А. Черешневым, - иммунофизиология, получение аутопротезов сосудов

Инвентарный номер: нет.        Г 12     Гаврилова, Т. В.     Миелопептиды в коррекции стрессорных и травматических изменений иммунного ответа на гетерологичный тимусзависимый антиген при проникающем ранении глаза крыс [Текст] / Т. В. Гаврилова, Н. Л. Беркасова, Ю. И. Шилов, М. В. Черешнева, В. А. Черешнев // Доклады Академии наук. - 2007. - Т. 412, № 5. - С. 697-699 : табл. - Библиогр.: с. 699 (10 назв.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ИНСТИТУТ ЭКОЛОГИИ И ГЕНЕТИКИ МИКРООРГАНИЗМОВ ПЕРМСКОГО НЦ УРО РАН -- ИНСТИТУТ ИММУНОЛОГИИ И ФИЗИОЛОГИИ УрО РАН -- ЧЕРЕШНЕВ ВАЛЕРИЙ АЛЕКСАНДРОВИЧ

Инвентарный номер: 200496 - кх; 200841 - бр. ф.    579    Э 64         Эндокринная регуляция физиологических функций [] : учебное пособие / В. Г. Климин [и др.]. ; РАН, УрО, Ин-т экологии и генетики микроорганизмов [и др.]. - Екатеринбург : [б. и.], 2001. - 104 с. - (Избранные разделы физиологии). - Б. ц. ГРНТИ 34.39 ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ЭНДОКРИНОЛОГИЯ -- БИОЛОГИЯ (ЭНДОКРИНОЛОГИЯ) -- СИСТЕМА ЭНДОКРИННАЯ (СТРОЕНИЕ) -- ГОРМОНЫ (ЭНДОКРИНОЛОГИЯ)

Инвентарный номер: нет.        М 54         Методология изучения системного воспаления / Е. Ю. Гусев, В. А. Черешнев, Л. Н. Юрченко, Н. В. Зотова // Цитокины и воспаление. - 2008. - Т. 7, № 1. - С. 15-23. - Библиогр.: с. 23 (14 назв.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ВОСПАЛЕНИЕ -- ЦИТОКИНЫ -- СИСТЕМНОЕ ВОСПАЛЕНИЕ -- СПОН \\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Цитокины и воспаление\\2008, Т. 7, № 1, С. 16-23.pdf

Инвентарный номер: нет.        Г 96     Гусев, Е. Ю.     Системное воспаление с позиций теории типового патологического процесса [Электронный ресурс] / Е. Ю. Гусев, Черешнев В. А., Л. Н. Юрченко // Цитокины и воспаление. - 2007. - Т. 6, № 4. - С. 9-21. - Библиогр.: с. 21 (10 назв.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): СВР -- СИСТЕМНОЕ ВОСПАЛЕНИЕ -- ТИПОВОЙ ПРОЦЕСС \\\\expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Цитокины и воспаление\\2007. Т. 6,№ 4. С. 9-21.pdf

Инвентарный номер: нет.        В 18         Варианты развития острого системного воспаления / Е. Ю. Гусев, Л. Н. Юрченко, В. А. Черешнев [и др.] // Цитокины и воспаление. - 2008. - Т. 7, № 2. - С. 9-17. - Библиогр.: с. 17 (26 назв.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): СИСТЕМНОЕ ВОСПАЛЕНИЕ -- ЦИТОКИНЫ -- ВОСПАЛИТЕЛЬНАЯ РЕАКЦИЯ \\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Цитокины и воспаление\\2008. Т. 7, №2. С. 9-17.pdf

Инвентарный номер: нет.        K 75     Korolevskaya, L. V.     Alkylhydroxybenzenes modify immune complex size [Electronic resource] / L. V. Korolevskaya, K. V. Shmagel, V. A. Chereshnev // Doklady biochemistry and biophysics. - 2012. - Vol. 446, № 1. - P229-230. - Bibliogr. : p. 230 (9 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ALKYLHYDROXYBENZENES -- IMMUNE COMPLEX \\\\expert2\\NBO\\Doklady Biochemistry and Biophysics\\2012, v.446, № 1. p.229-230.pdf

Инвентарный номер: нет.        P 93         Proliferativeresponse of lymphocyte to pokeweed mitogen depends on the concentration of endogenous cortisol in the early post-traumatic period in patients with penetrating eye injury / V. A. Chereshnev, Yu. I. Shilov , T. V. Gavrilova [et al.] // Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 5. - P722-725. - Bibliogr. : p. 724-725 (15 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): LYMPHOCYTES -- CORTISOL -- PENETRATING EYE INJURY Аннотация: The intensity of lymphocyte proliferation in response to pokeweed mitogen depends on cortisol level in the peripheral blood in the early post-traumatic period of penetrating eye injury. Lymphocyte proliferation in 72- and 96-h cultures from patients with high levels of endo genous hormone was suppressed. In 120-h cultures, the intensity of proliferation remains unchanged. Lymphocyte blast transformation was increased in 120-h cultures from patients with normal cortisol concentration and remained unchanged in case of low cortisol level \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 5, p. 722-725.pdf

Инвентарный номер: нет.        E 97         Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis / V. A. Chereshnev, L. V. Gankovskaya, L. V. Koval'chuk [et al.] // Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 2. - P236-239. - Bibliogr. : p. 239 (11 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): INNATE IMMUNITY -- HERPETIC INFECTION -- KERATITIS Аннотация: The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and beta-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 2, p. 236-239.pdf

Инвентарный номер: нет.        M 99         Myelopeptides regulate the microbicidic and secretory activities of Innate immunity effectors / V. A. Chereshnev, S. V. Gein, L. S. Mazunina [et al.] // Doklady biochemistry and biophysics. - 2011. - Vol. 436, № 1. - P53-55. - Bibliogr. : p. 55 (9 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- MICROBICIDIC -- INNATE iMMUNITY \\\\expert2\\NBO\\Doklady Biological Sciences\\2011. V. 436, N 1.P. 53-55.pdf

Инвентарный номер: нет.        S 54     Shmagel, K. V.     Molecular bases of immune complex pathology [Electronic resource] / K. V. Shmagel, V. A. Chereshnev // Biochemistry. - 2009. - Vol. 74, № 5. - P469-479. - Bibliogr. : p. 477-479 (126 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNE COMPLEXES -- COMPLEMENT -- CR1 RECEPTORS Аннотация: The binding of antigens with antibodies forms immune complexes in the body. Usually these complexes are eliminated by the system of mononuclear phagocytes without development of pathological changes. This review highlights principal mechanisms responsible for safe removal of immune complexes in primates and humans. Special attention is given to diseases known as "immune complex diseases", when antigen-antibody complexes induce inflammatory reactions. The review considers key experimental works that significantly contributed to current knowledge of etiology and pathogenesis of type III hypersensitivity. Some factors of the development of immune complex syndrome such as level of humoral immune response to antigen, isotype and affinity of forming antibodies, the amount of immune complexes, and the consequences of their interaction with the complement system and Fc-receptors are analyzed based on the molecular mechanisms involved. The review contains a retrospective analysis of the most significant scientific achievements in immune complex pathology investigation within the last 100 years \\\\expert2\\NBO\\Biochemistry\\2009, v.74, p. 469-479.pdf

Инвентарный номер: нет.        I-57         In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber / M. S. Kuyukina, I. B. Ivshina, S. V. Gein, V. A. Chereshnev // Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 5. - P326-330 ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ACTINOBACTERIA -- RHODOCOCCUS RUBER -- BIOSURFACTANT Аннотация: The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1 beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1 beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug \\\\Expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2007, v.144, N 3, p. 326.pdf

Инвентарный номер: нет.        F 33         Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323 ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation \\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf

Инвентарный номер: нет.        G 33     Gein, S. V.     Effect of myelopeptides on IFN-γ and IL-4 production by peripheral blood lymphocytes [Electronic resource] / S. V. Gein, T. V. Gavrilova, V. A. Chereshnev // Doklady Biological Sciences. - 2007. - Vol. 413, № 1. - P161-163 : рис., a-табл. ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- IL-4 PRODUCTION -- LYMPHOCYTES \\\\expert2\\NBO\\Doklady Biological Sciences\\2007. V. 413, N 1.P. 161.pdf

Инвентарный номер: нет.        I-56         Impact of bacterial autoregulatory molecules (homoserine lactones and alkylhydroxybenzenes) on the oxidative metabolism of the cell effectors of natural immunity / D. G. Deryabin, T. G. Sviridova, G. I. El'-Registan, V. A. Chereshnev // Microbiology. - 2013. - Vol. 82, № 2. - P133-141 ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ALKYLHYDROXYBENZENES -- CHEMOLUMINESCENCE -- HOMOSERINE LACTONES Аннотация: We investigated the impact of bacterial regulators homoserine lactones (HSLs) and alkylhydroxybenzenes (AHBs) (which are present in human fluids at pico- and nanomolar concentrations) on neutrophile oxidative metabolism. The HSL and AHB effects were determined using a test based on induced luminol-dependent chemoluminescence of neutrophiles in human peripheral blood. In this test, neutrophiles were preincubated with chemical analogs of bacterial autoregulators with different lengths of the hydrocarbon radical, such as HSL · HCl, C6- and C12-HSL, and C1-, C6-, and C12-AHB. We revealed that they suppressed the chemoluminescence and, accordingly, the oxidative metabolism of neutrophiles. This effect was more significant with HSLs than with AHBs. Within each of the two groups, the effect increased with an increase in the length of the hydrocarbon chain of the homologues. High concentrations of long-chain autoregulators of both types produce a cytotoxic effect that is associated with apoptosis in the case of C12-HSL and with cell membrane damage in the case of C12-AHB. The effects of low HSL and AHB concentrations involve their protein-modifying properties and result in changes in the activities of neutrophile oxidative enzymes. To a lesser extent, these effects are due to the pro- and antioxidant activities of HSLs and AHBs, respectively. In light of the results obtained, the HSL and AHB effects are to be considered as a novel mechanism of regulating the activities of cell effectors of natural innate immunity. In symbiotic and parasitic systems, the mechanism involves the bimodal pattern of the effects of HSLs and AHBs that vary depending on their structure and concentrations

Инвентарный номер: нет.        A 10         A new approach to making autoprostheses for angioplasty / V. A. Chereshnev, B. G. Yushkov, N. V. Tyumentseva [et al.] // Doklady Biological Sciences. - 2006. - Vol. 408, № 1. - P211-213 ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ANGIOPLASTY -- ANIMAL -- AUTOTRANSPLANTATION \\\\expert2\\nbo\\Doklady Biological Sciences\\2006. V. 408, N 1.P. 211-213.pdf

Инвентарный номер: нет.        T 44         The role of monocytes in the effects of β-endorphin and selective agonists of μ-and δ-opiate receptors on the proliferative activity of peripheral blood lymphocytes / S. V. Gein, T. A. Baeva, O. N. Gein, V. A. Chereshnev // Human Physiology. - 2006. - Vol. 32, № 3. - P346-350 ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MONOCYTES -- BETA ENDORPHIN -- BLOOD LYMPHOCYTES Аннотация: The effects of β-endorphin under the conditions of naloxone hydrochloride blockade of opiate receptors, as well as the effects of the selective agonists of μ-and δ-receptors DAGO and DADLE and the effects of melanocyte-potentiating factor (MPF), on the in vitro proliferative response of lymphocytes were studied. The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA). The tetrapeptide MPF, which is the C-terminal sequence of β-endorphin, had almost no effect on the proliferative activity of lymphocytes. β-Endorphin, naloxone, and the μ-and δ-receptor selective agonists enhanced the proliferative response of lymphocytes in an unfractionated cell culture, whereas β-endorphin, naloxone, and DAGO suppressed the proliferative activity of lymphocytes in the mononuclear fraction purified of monocytes. In both cases, the naloxone blockade of opiate receptors enhanced rather than eliminated the β-endorphin e \\\\expert2\\nbo\\Human Physiology\\2006. V. 32, N 3. P. 346-350.pdf

Инвентарный номер: нет.        S 98         System of hemopoiesis and morphogenesis [Electronic resource] / B. G. Yushkov, V. A. Chereshnev, N. V. Tyumentseva, O. S. Artashyan, A. I. Kuz'min // Bulletin of experimental biology and medicine. - 2005. - Vol.140, №5. - P627-630. - Bibliogr. : p. 630 (6 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): AUTOPROSTHESES -- HEMOPOIESIS -- MORPHOGENETIC FUNCTION Аннотация: Method of transplantation of hemopoietic cells is proposed for acceleration of recovery of damaged tissue structures. The morphogenetic effect of transplantation depended on the state of damaged tissue and was determined by not only hemopoietic stem cells, but also lymphocytes, macrophages, and mast cells \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 5, p. 627.pdf

Инвентарный номер: нет.        R 74         Role of functional activity of phagocytic mononuclear system in the formation of autoprostheses for angioplasty [Electronic resource] / V. A. Chereshnev, N. V. Tyumentseva, B. G. Yushkov, I. G. Danilova, V. V, Khodakov, D. I. Krokhin, S. Yu. Medvedeva // Bulletin of experimental biology and medicine. - 2005. - Vol. 140, № 2. - P217-218. - Bibliogr. : p. 218 (9 ref.) ББК 57 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CARRAGEENAN -- PHAGOCYTIC MONONUCLEAR SYSTEM -- TAMERITE Аннотация: The possibility of formation of connective-tissue vascular prostheses on subcutaneously implanted polychlorovynil base was demonstrated in experiments on rats. Suppression of the function of phagocytic cell with carrageenan decelerates, while its stimulation with tamerit accelerates the formation of connective-tissue autoprostheses. \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2005, v.140, N 2, p. 217.pdf