E 27 Effects of myelopeptides on immune response and morphometrical manifestations of inflammation in experimental penetrating wound of the eye / N. L. Berkasova, T. V. Gavrilova, Yu. I. Shilov [et al.] // Bulletin of experimental biology and medicine. - 2008. - Vol. 145, № 3. - P341-343 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- MYELOPID -- PENETRATING WOUND OF THE EYE Аннотация: Myelopid and MP-1 myelopeptide increase the count of antibody-producing cells, reduced under the effect of injury and standard therapy, and do not modify the suppression of delayed hypersensitivity. Injections of myelopid and MP-3 together with standard drugs optimized the traumatic inflammation processes \\\\expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2008, v.145, N 3, p. 341.pdf |
K 75 Korolevskaya, L. V. Alkylhydroxybenzenes modify immune complex size [Electronic resource] / L. V. Korolevskaya, K. V. Shmagel, V. A. Chereshnev // Doklady biochemistry and biophysics. - 2012. - Vol. 446, № 1. - P229-230. - Bibliogr. : p. 230 (9 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ALKYLHYDROXYBENZENES -- IMMUNE COMPLEX \\\\expert2\\NBO\\Doklady Biochemistry and Biophysics\\2012, v.446, № 1. p.229-230.pdf |
P 93 Proliferativeresponse of lymphocyte to pokeweed mitogen depends on the concentration of endogenous cortisol in the early post-traumatic period in patients with penetrating eye injury / V. A. Chereshnev, Yu. I. Shilov , T. V. Gavrilova [et al.] // Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 5. - P722-725. - Bibliogr. : p. 724-725 (15 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): LYMPHOCYTES -- CORTISOL -- PENETRATING EYE INJURY Аннотация: The intensity of lymphocyte proliferation in response to pokeweed mitogen depends on cortisol level in the peripheral blood in the early post-traumatic period of penetrating eye injury. Lymphocyte proliferation in 72- and 96-h cultures from patients with high levels of endo genous hormone was suppressed. In 120-h cultures, the intensity of proliferation remains unchanged. Lymphocyte blast transformation was increased in 120-h cultures from patients with normal cortisol concentration and remained unchanged in case of low cortisol level \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 5, p. 722-725.pdf |
E 97 Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis / V. A. Chereshnev, L. V. Gankovskaya, L. V. Koval'chuk [et al.] // Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 2. - P236-239. - Bibliogr. : p. 239 (11 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): INNATE IMMUNITY -- HERPETIC INFECTION -- KERATITIS Аннотация: The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and beta-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 2, p. 236-239.pdf |
M 99 Myelopeptides regulate the microbicidic and secretory activities of Innate immunity effectors / V. A. Chereshnev, S. V. Gein, L. S. Mazunina [et al.] // Doklady biochemistry and biophysics. - 2011. - Vol. 436, № 1. - P53-55. - Bibliogr. : p. 55 (9 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): MYELOPEPTIDES -- MICROBICIDIC -- INNATE iMMUNITY \\\\expert2\\NBO\\Doklady Biological Sciences\\2011. V. 436, N 1.P. 53-55.pdf |
R 30 Reaction diffusion modelling of interferon distribution in secondary lymphoid organs / G. Bocharov, A. Danilov, Y. Vassilevski [et al.] // Mathematical modelling of natural phenomena. - 2011. - Vol. 6, № 7. - P13-26 Рубрики: НАУКА. НАУКОВЕДЕНИЕ Кл.слова (ненормированные): SYSTEMS -- RECIRCULATION -- LYMPHOCYTES Аннотация: This paper proposes a quantitative model of the reaction-diffusion type to examine the distribution of interferon-alpha (IFN alpha) in a lymph node (LN). The numerical treatment of the model is based on using an original unstructured mesh generation software Ani3D and nonlinear finite volume method for diffusion equations. The study results in suggestion that due to the variations in hydraulic conductivity of various zones of the secondary lymphoid organs the spatial stationary distribution of IFN alpha is essentially heterogeneous across the organs. Highly protected domains such as sinuses, conduits, co-exist with the regions in which where the stationary concentration of IFN alpha is lower by about 100-fold. This is the first study where the spatial distribution of soluble immune factors in secondary lymphoid organs is modelled for a realistic three-dimensional geometry \\\\expert2\\nbo\\Mathematical Modelling and Natural Phenomena\\2011. Vol.6, №7. С. 13-26.pdf |
Modulation of Cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus Biosurfactant / V. A. Chereshnev, S. V. Gein, T. A. Baeva [et al.] // Bulletin of experimental biology and medicine. - 2010. - Vol. 149, № 6. - P734-738 Кл.слова (ненормированные): RHODOCOCCUS RUBBEr -- GLYCOLIPID BIOSURFACTANT -- INTERLEUKIN-10 Аннотация: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells \\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2010, v.149, N 6, p. 734-738.pdf |
R 87 Rozental', O. M. A normative model of balanced nature management [Electronic resource] / O. M. Rozental', V. A. Chereshnev // Russian Journal of Ecology. - 2010. - Vol. 41, № 4. - P356-363. - Bibliogr. : p. 363 (13 ref.) Рубрики: НАУКА. НАУКОВЕДЕНИЕ Кл.слова (ненормированные): MEASURING CONTROL -- TRACEABILITY -- VARIABILITY OF CONTROLLED PARAMETERS Аннотация: The risk of erroneous regulation in multilevel normative environmental chains, at the federal, regional, and lower levels, down to the corporate one, has been studied. This risk has been demonstrated to increase unacceptably rapidly in the framework of the existing system of "unconditional acceptance" of normative standards. To mend the situation, it is necessary to use the "conditional acceptance" model by regarding post hoc decisions made at higher levels as a priori ones at the next (lower) levels. A strategy of environmentally and economically balanced corporate regulation of nature management through minimization of the losses resulting from both excessive caution and breaching the existing regulations has been proposed. This system, combined with the European approach to nature conservation, requires that the "riskless" regulation should be abandoned and is expected to improve the parameters of nature management quality by three to four orders of magnitude \\\\expert2\\NBO\\Russian Journal of Ecology\\2010. V. 41, N 4. P. 356-363.pdf |
S 54 Shmagel, K. V. Molecular bases of immune complex pathology [Electronic resource] / K. V. Shmagel, V. A. Chereshnev // Biochemistry. - 2009. - Vol. 74, № 5. - P469-479. - Bibliogr. : p. 477-479 (126 ref.) Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): IMMUNE COMPLEXES -- COMPLEMENT -- CR1 RECEPTORS Аннотация: The binding of antigens with antibodies forms immune complexes in the body. Usually these complexes are eliminated by the system of mononuclear phagocytes without development of pathological changes. This review highlights principal mechanisms responsible for safe removal of immune complexes in primates and humans. Special attention is given to diseases known as "immune complex diseases", when antigen-antibody complexes induce inflammatory reactions. The review considers key experimental works that significantly contributed to current knowledge of etiology and pathogenesis of type III hypersensitivity. Some factors of the development of immune complex syndrome such as level of humoral immune response to antigen, isotype and affinity of forming antibodies, the amount of immune complexes, and the consequences of their interaction with the complement system and Fc-receptors are analyzed based on the molecular mechanisms involved. The review contains a retrospective analysis of the most significant scientific achievements in immune complex pathology investigation within the last 100 years \\\\expert2\\NBO\\Biochemistry\\2009, v.74, p. 469-479.pdf |
I-60 Inflammation markers in atherosclerosis development / A. P. Shavrin, Y. V. Khovaeva, V. A. Chereshnev, B. V. Golovskoy // Cardiovascular therapy and prevention. - 2009. - Vol. 8, № 3. - P13-15 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): CONGESTIVE-HEART-FAILURE -- TUMOR-NECROSIS-FACTOR -- DEPENDENT VASODILATION Аннотация: To study different inflammation markers at various stages of atherosclerosis progression. Material and methods. In 174 21-70-year-old people, brachial artery ultrasound (Aloka 5000) was performed to Visualize atherosclerotic plaques and assess intima-media thickness (IMT). Immuno-enzyme analysis was used to measure plasma levels of C-reactive protein, CRP (SeroELISA test system, Diagnostic Systems Laboratories, USA), and cytokines - tumor necrosis factor alpha (THF-alpha), interleukins 1, 4 and 8 (1L-1, 2, and 8) (Russian test systems, Cytokine company, St. Petersburg |
I-57 In vitro immunomodulating activity of biosurfactant glycolipid complex from Rhodococcus ruber / M. S. Kuyukina, I. B. Ivshina, S. V. Gein, V. A. Chereshnev // Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 5. - P326-330 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ACTINOBACTERIA -- RHODOCOCCUS RUBER -- BIOSURFACTANT Аннотация: The biosurfactant glycolipid complex synthesized by Rhodococcus ruber actinobacteria is not toxic and exhibits no appreciable effect on proliferative activity of peripheral blood leukocytes. In the monocyte fraction, the biosurfactant activates the production of IL-1 beta and TNF-alpha cytokines without modifying the production of IL-6. In the mononuclear fraction, the glycolipid biosurfactant exhibited no effects on the production of IL-1 beta, TNF-alpha, and IL-6. These results indicate good prospects for further studies of immunomodulating and antitumor activities of biosurfactant drug \\\\Expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2007, v.144, N 3, p. 326.pdf |
E 27 Effect of "Profetal" on differentiation and functional activity of human mononuclear leukocytes [Text] / O. V. Lebedinskaya, N. P. Velizheva, F. V. Donenko, V. A. Chereshnev // Bulletin of experimental biology and medicine. - 2006. - Vol. 141, № 4. - P536-543 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): ALPHA-FETOPROTEIN -- "PROFETAl" -- MONONUCLEAR LEUKOCYTES \\\\expert2\\nbo\\Bulletin of Experimental Biology and Medicine\\2006, v.141, N 4, p. 536.pdf |
H 91 Human immunodeficiency virus infection: From biological observations to mechanistic mathematical modelling / G. Bocharov, V. A. Chereshnev, I. C. Gainova [et al.] // Mathematical modelling of natural phenomena. - 2012. - Vol. 7, № 5. - P78-104. - Bibliogr. : p. 93-104 (275 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): HOST-PATHOGEN INTERACTION -- IMMUNE SYSTEM -- HUMAN IMMUNODEFICIENCY Аннотация: HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to 'dynamic' categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis \\\\expert2\\NBO\\Mathematical Modelling and Natural Phenomena\\2012. V. 7, N 5. P. 78-104.pdf |
T 44 The effect of polyoxidonium on immune response and morphological parameters of inflammation after experimental penetrating eye injury / V. A. Chereshnev, M. V. Chereshneva, Yu. I. Shilov [et al.] // Doklady Biological Sciences. - 2012. - Vol. 443, № 1. - P75-77. - Bibliogr. : p. 77 (10 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): AZOXIMER BROMIDE -- DEXAMETHASONE -- HETEROPHILE ANTIGEN \\\\expert2\\NBO\\Doklady Biological Sciences\\2012. V. 443, N 1. P. 75-77.pdf |
E 27 Effect of myelopeptides on reactive oxygen species generation and IL-1beta and TNF-alpha production by peripheral blood cells / // Patologicheskaia fiziologiia i èksperimental'naia terapiia. - 2012. - № 1. - P19-22 Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): IL1B PROTEIN -- HUMAN -- IMMUNOLOGICAL ADJUVANT Аннотация: Myelopeptides MP-3, MP-5, and MP-6 were found to suppress zymosan-induced production of reactive oxygen species by leukocytes both under one-way introduction and under pretreatment. All of myelopeptides under examination in case of one-way introduction in cultures with zymosan demonstrated a decrease in zymosan-stimulated (1500 mkg/ml) production of IL-1beta, and activation of spontaneous production of this cytokine by whole blood cells. TNF-alpha production under myelopeptide effect was lowered in cultures with 150 mkg/ml zymosan. Under pretreatment myelopeptides did not render effect on IL-1beta and TNF-alpha production, with the exception of single stimulating effect of MP-5 on IL-1beta level in spontaneous cultures. Using comparative analysis the difference in direction and expressivity of effects of various myelopeptides was not revealed that suggests the existence of common mechanism of action in this group of peptide bioregulators. |
I-57 In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: Role of monocyte adhesion / S. V. Gein, M. S. Kuyukina, I. B. Ivshina, V. A. Chereshnev // Cytotechnology. - 2011. - Vol. 63, № 6. - P559-566. - Bibliogr. : p. 565-566 (23 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): CYTOKINE-STIMULATING ACTIVITY -- GLYCOLIPID BIOSURFACTANT -- MONOCYTE ADHESION Аннотация: Glycolipid biosurfactant (GLB) from Rhodococcus ruber IEGM 231 was found to stimulate tumor necrosis factor-α (TNF-α), interleukin (IL) -1β and IL-6 production when applied as an ultrasonic emulsion to the adherent human peripheral blood monocyte culture. However, a lack of cytokine-stimulating activity was registered with the GLB applied as a hydrophobic film coating in 24-well culture plates, indicating that it may have been due to its inhibitory effect on monocyte adhesion. The mode of GLB application may therefore play an important role in in vitro assay of immunostimulatory activity of this compound as well as other bacterial glycolipids. Additionally, GLB from R. ruber displayed no cytotoxicity against human lymphocytes and therefore could be proposed as a potential immunomodulating and antitumor ag \\\\expert2\\NBO\\Cytotechnology\\2011. V. 63, N 6. P. 559-566.pdf |
R 45 Research priorities for HIV/M. tuberculosis co-infection [Text] / M. A. Alvarez, Patricia Arbelae, Francisko Ignacio Bastos [et al.] // Open Infectious Diseases Journal. - 2011. - Vol. 5, № 1. - P14-20. - Bibliogr. : p. 19-20 (40 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): AIDS/TB -- PRIORITY AREAS -- JOINT Аннотация: This document summarizes priority areas for joint research and concerted actions to counteract the public health threat of AIDS/TB as identified within the European Support Action "EUCO-Net" funded under the 7th Framework Programme of the European Commission \\\\expert2\\nbo\\The Open Infectious Diseases Journal\\2011. - Vol.5, №1. - С. 14-20.pdf |
S 61 Simulation of the interferon-mediated protective field in lymphoid organs with their spatial and functional organization taken into consideration / G. A. Bocharov, A. A. Danilov, Y. Vassilevski , V. A. Chereshnev // Doklady Biological Sciences. - 2011. - Vol. 439, № 1. - P194-196. - Bibliogr. : p. 196 (10 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): ALPHA INTERFERON -- CYTOKINE -- CYTOLOGY \\\\expert2\\NBO\\Doklady Biological Sciences\\2011. V. 439, N 1.P. 194-196.pdf |
F 33 Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323 Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation \\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf |
D 44 Dependence of the lymphocyte proliferative response on the endogenous cortisol level and sensitivity to β-adrenergic regulation in vitro in the early period of penetrating eye injury / V. A. Chereshnev, M. V. Chereshneva, Yu. I. Shilov, T. V. Gavrilova // Doklady Biological Sciences. - 2010. - Vol. 434, № 1. - P304-306. - Bibliogr. : p. 306 (10 ref.) Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ Кл.слова (ненормированные): CELL PROLIFERATION -- DRUG EFFECT -- EYE INJURY \\\\expert2\\NBO\\Doklady Biological Sciences\\2010. V. 434, N 1.P. 304-306.pdf |