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 Найдено в других БД:Каталог книг и продолжающихся изданий (2)Публикации Чарушина В.Н. (27)
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Общее количество найденных документов : 89
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1.
Инвентарный номер: нет.
   
   K 46

   
    Kinetic resolution of racemic heterocyclic amines with N-tosyl-(S)-prolyl chloride / D. A. Gruzdev, S. A. Vakarov, G. L. Levit, V. P. Krasnov // 18th European Symposium on Organic Chemistry ESOC-2013, Marseille, France, 7-12 July 2013 : book of abstracts. - Marseille (France), 2013. - 245 (P1-185)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
RACEMIC AMINES -- HETEROCYCLIC AMINES -- CHLORIDE

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2.
Инвентарный номер: нет.
   
   L 62

    Levit, G. L.
    Acylative Kinetic Resolution with Chiral Acyl Chlorides as an Efficient Preparative Approach for Enantio Pure Heterocyclic Amines / G. L. Levit, V. P. Krasnov // CHIRALITY 2014 : book of abstr., Prague, Czech Republic, 27-30 July 2014. - 2014. - P. 218 (P-099)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CHIRAL ACYL CHLORIDES -- HETEROCYCLIC AMINES

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3.
Инвентарный номер: нет.
   
   A 19

   
    Acylative kinetic resolution of racemic amines with N-protected (S)-amino acyl chlorides / D. A. Gruzdev, G. L. Levit, V. P. Krasnov, V. N. Charushin // 18th European Symposium on Organic Chemistry ESOC-2013, Marseille, France, 7-12 July 2013 : book of abstracts. - Marseille (France) , 2013. - 244 (P1-184)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
RACEMIC AMINES -- CHLORIDES -- ACYLATIVE KINETIC RESOLUTION

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4.
Инвентарный номер: нет.
   
   M 78

   
    Modulation of inflammatory response improves myocardial infarct healing in rats / A. Sarapultsev, O. N. Chupakhin, P. Sarapultsev, M. T. Abidov, I. Danilova // Current Pharmaceutical Design . - 2014. - Vol.20, №12. - С. 1980-1986
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
INFLAMMATION -- L-17 COMPOUND -- MYOCARDIAL INFARCTION
Аннотация: It is reputed that the ideal therapeutic approaches to treatment of patients with acute coronary syndrome (ACS) and myocardium infarction (MI) should be aimed at the inflammation reaction triggers. This study investigated the effectiveness of the impact of L-17 compound of the group of 5- phenyl substituted-6H-1,3,4-thiadiazine-2-amines upon the course of experimental MI as compared to the impact of a preparation, officially registered in Russia as an immunomodulator, Tamerit, belonging to phthalhydrazid derivative substance. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections and biochemical analysis has been carried out at the 1st and 7th days of the experimental MI. The conducted investigations have shown that under the action of immunocorrectors the inflammation reaction character changes, exudative/destructive inflammation is replaced by a proliferative-cellular one. Animals' blood biochemical analysis at the background of L-17 and Tamerit introduction has shown a decrease of aminotransferases and lactatedehydrogenases activity in blood as compared to the reference group of animals' indicators, which is evidently caused by epicardial injury of myocardium and lesser amount of the alternative cardiomyocytes. At the same time, no noticeable difference in biochemical characteristics in groups, having been treated to immunomodulators of different chemical composition was identified, which is the sign of the essential similarity of their impact. Thus, immunocorrectors of different chemical groups (Tamerit and compound L17) diminish the volume of initial myocardial infarction and accelerate the granulation processes in course of MI, and represent a new category of treatment agents

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5.
Инвентарный номер: нет.
   
   L 62

    Levit, G. L.
    Acylative kinetic resolution with chiral acyl chlorides as an efficient preparative approach for enantio pure heterocyclic amines / G. L. Levit, V. P. Krasnov // CHIRALITY 2014. 26-th International Symposium on Chiral Discrimination, ISCD-26, Prague, Czech Repablic, 27-30 July 2014 : book of asbstracts. - Prague, 2014. - 218 (P-099). - Bibliogr. : p. 218 (2 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
HETEROCYCLIC AMINES -- RESOLVING AGENTS -- SYNTHESIS

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6.
Инвентарный номер: нет.
   
   I-60

   
    Influence of a biologically active compound from substituted thiadiazines on transaminase activity in myocardial homogenate in experimental myocardial infarction [Electronic resource] / O. N. Chupakhin, A. Sarapultsev, M. Chereshneva, I. Gette, L. P. Sidorova, I. Danilova, P. Sarapultsev // International Journal of Pharmacy and Pharmaceutical Sciences. - 2015. - Vol. 7, № 6. - С. 147-151. - Bibliogr. : p. 151 (21 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ENZYMES -- MYOCARDIAL INFARCTION -- L-17 COMPOUND
Аннотация: Objective: Earlier works have reported on the effectiveness of the compounds of the group of substituted 5R1, 6R2, 3,4-thiadiasine-2-amines for treating experimental myocardial infarction, conditioned by the immune-modifying action of the compound. The purpose of this study was to evaluate the action of the L17 compound of the group of substituted 5R1, 6R2, 3,4-thiadiasine-2-amines on the extent of injury and the possible recurrence of experimental myocardial infarction by the dynamic assessment of transaminase activity in blood and myocardial homogenate (tissue). Methods: Modelling of myocardial infarction in rats was performed in accordance with the author’s modification of the standard ligation model. Tissue enzyme activity of LDH and CK-MB was evaluated at days 1, 7, and 14. Results: According to the results, the decrease in LDH 1-2 activity in tissue (after experimental myocardial infarction) corresponded to the increase in enzyme activity in blood on the first day of the experiment. However, on the seventh day of the experiment, the decrease of LDH 1-2 activities in the tissue of animals treated with L17 compound corresponded with the decrease of LDH activity in blood, while in non-treated animals the relation between the enzyme levels in blood and tissue was typical for the onset of MI. Conclusions: The evaluation of enzyme levels in myocardial tissue confirms previouslyreported data that the administration of a thiadiazine compounds prevents the recurrence and decreases the size of experimental myocardial infarction.

\\\\expert2\\nbo\\International Journal of Pharmacy and Pharmaceutical Sciences\\52015. V. 7, N 6. P. 147-151.pdf
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7.
Инвентарный номер: нет.
   
   E 27

   
    Effect of a New Class of Compounds of the Group of Substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction [Electronic resource] / A. Sarapultsev, O. N. Chupakhin, P. Sarapultsev, M. Rantsev, S. Medvedeva, L. P. Sidorova // Current Vascular Pharmacology. - 2015. - Vol. 13, № 1. - С. 43-53
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CYTOKINES -- MYOCARDIAL INFARCTION -- L-17 COMPOUND
Аннотация: This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the immune response and the plasma level of circulating cytokines in acute myocardial infarction (MI) in rats. The study was based upon experimental work which demonstrated the role of local and systemic inflammatory reactions in MI. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections has been carried out at the 1st and 7th days of the experimental myocardial infarction. Serum activity of creatine phosphokinase (CPK), aspartate aminotransferase (AST), isoenzymes 1 and 2 and lactate dehydroge nase (LDH1-2) were investigated at days 1 and 7. ELISA analysis for plasma cytokine levels was performed using commercially available test kits following the manufacturer's instructions. Biochemical analysis in animals with the administration of the L-17 compound after MI showed that the AST and CPK levels at days 5 and 7 of experiments did not differ significantly from the values of intact animals. In animals of the group with MI without the administration of the L-17 compound, the IL-1 level 8 times and the TNF level 7.8 times exceeded the normal indicators, while the use of L-17 compound in the therapy resulted in only 1.8 times increase of IL-1 level and 4.7 times increase of TNF level in comparison with the norm. Thus, the introduction of L-17 compound in case of experimental MI delays exudative/alternative phase of inflammation, accelerates granulocytic and decreased the inflammation and anti-inflammation interleukins level.

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8.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of novel purin-6-yl conjugates with heterocyclic amines linked via 6-aminohexanoyl fragment [Electronic resource] / E. V. Verbitskiy, E. M. Cheprakova, P. A. Slepukhin, M. A. Kravchenko, S. N. Skornyakov, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Mendeleev Communications. - 2015. - Vol. 25. - С. 412-414. - Bibliogr. : p. 414 (30 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
2-AMINOPURINE -- PURIN-6-YL -- HETEROCYCLIC AMINES
Аннотация: Novel conjugates of purine and 2-aminopurine linked with heterocyclic amines, including chiral derivatives of 3,4-dihydro- 2H-[1,4]benzoxazine, 3,4-dihydro-2H-[1,4]benzothiazine and 1,2,3,4-tetrahydroquinoline, by 6-aminohexanoyl fragment at the 6-position of purine moiety were obtained. For this purpose, replacement of the chlorine atom in 2-amino-6-chloropurine or 6-chloropurine by direct nucleophilic substitution reaction with 6-aminohexanamides or the coupling of 6-(purin-6-ylamino)-6- hexanoic acid with nitrogen heterocycles were used.

\\\\expert2\\nbo\\Mendeleev Communications\\2015, v.25, p. 412.pdf
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9.
Инвентарный номер: нет.
   
   T 44

   
    The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction [Electronic resource] / P. Sarapultsev, O. N. Chupakhin, S. Medvedeva, E. A. Mukhlynina, S. A. Brilliant, L. P. Sidorova, I. Danilova, A. Sarapultsev // International Immunopharmacology. - 2015. - Vol. 25, № 2. - С. 440-449. - Bibliogr. : p. 447-449 (101 ref)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
STRESS -- THIADIAZINES -- L-17 COMPOUND
Аннотация: A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6 ha day. Parameters of the morphological and functional states of the organs studied were measured and biochemical and enzyme-immunoassays were carried out on the first and second days. This study reveals that the main mechanism by which the L17 compound mediates of its anti-stress was by activation of macrophages on the second day of the experiments and the inhibition of apoptosis in the thymus. The results enable us to suggest that the compound L17 does not improve resistance to stress; however, it does lower the reaction to stress.

\\\\expert2\\nbo\\International Immunopharmacology\\2015. V. 25, N 2. P. 440-449.pdf
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10.
Инвентарный номер: нет.
   
   E 27

   
    Effect of a New Class of Compounds of the Group of Substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction - See more at: http://www.eurekaselect.com/109541/article#sthash.ffuxVde4.dpuf [Electronic resource] / A. Sarapultsev, O. N. Chupakhin, P. Sarapultsev, M. Rantsev, S. Medvedeva, L. P. Sidorova, I. Danilova // Current Vascular Pharmacology. - 2015. - Vol. 13, № 1. - С. 43-53
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CYTOKINES -- MYOCARDIAL INFARCTION -- L-17 COMPOUND -- INFLAMMATION
Аннотация: This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2- 1,3,4-thiadiazine-2-amines on the immune response and the plasma level of circulating cytokines in acute myocardial infarction (MI) in rats. The study was based upon experimental work which demonstrated the role of local and systemic inflammatory reactions in MI. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections has been carried out at the 1th and 7th days of the experimental myocardial infarction. Serum activity of creatine phosphokinase (CPK), aspartate aminotransferase (AST), isoenzymes 1 and 2 and lactate dehydroge nase (LDH1-2) were investigated at days 1stand 7th. ELISA analysis for plasma cytokine levels was performed using commercially available test kits following the manufacturer's instructions. Biochemical analysis in animals with the administration of the L-17 compound after MI showed that the AST and CPK levels at days 5 and 7 of experiments did not differ significantly from the values of intact animals. In animals of the group with MI without the administration of the L-17 compound, the IL-1 level 8 times and the TNF level 7.8 times exceeded the normal indicators, while the use of L-17 compound in the therapy resulted in only 1.8 times increase of IL-1 level and 4.7 times increase of TNF level in comparison with the norm. Thus, the introduction of L-17 compound in case of experimental MI delays exudative/alternative phase of inflammation, accelerates granulocytic and decreased the inflammation and anti-inflammation interleukins level. - See more at: http://www.eurekaselect.com/109541/article#sthash.ffuxVde4.dpuf

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