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1.
Инвентарный номер: нет.
   
   C 75


   
    Construction of Heteroacenes with Fused Thiophene and Pyrrole Rings via the Fischer Indolization Reaction [Electronic resource] / R. A. Irgashev, A. A. Karmatsky, G. L. Rusinov, V. N. Charushin // Organic Letters. - 2016. - Vol. 18, № 4. - С. 804-807
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
FUSED THIOPHENE -- PYRROLE RINGS -- FISCHER INDOLIZATION REACTION
Аннотация: A convenient approach to ladder-type 6H-benzo[4',5']thieno[2',3':4,5]thieno[3,2-b]indoles, e.g., I (X-rays single crystal structure shown)​, bearing various substituents in both terminal benzene rings has been developed. The protocol suggested for prepg. these N,S-​heteroacenes is based on using easily available reagents, such as cinnamic acids and arylhydrazines, which can be involved in the Fischer indole synthesis, as the key step. A similar condensed system of 12H-​benzo[4'',​5'']​thieno[2'',3'':4',5']​thieno[2',3':4,5]​thieno[3,2-b]indole, bearing six rings, has also been obtained.

\\\\expert2\\nbo\\Organic Letters\\2016, v.18, N 4, p.804-807,pdf.pdf
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2.
Инвентарный номер: нет.
   
   D 47


   
    Detection of nitroaromatic explosives by new D-π-A sensing fluorophores on the basis of the pyrimidine scaffold [Electronic resource] / E. V. Verbitskiy, A. A. Baranova, K. I. Ludovik, M. Z. Shafikov, K. O. Khokhlov, E. M. Cheprakova, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Analytical and Bioanalytical Chemistry. - 2016. - Ahead of Print
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
NITROAROMATIC EXPLOSIVES -- PYRIMIDINE SCAFFOLD
Аннотация: A series of D-​π-​A- type dyes based on pyrimidines, bearing various thiophene linkers, have been studied as sensing fluorophores. Fluorescence studies have demonstrated that the emission of all derivs. is sensitive to the presence of nitroarom. explosives, such as 2,​4,​6-​trinitrophenol (PA)​, 2,​4,​6-​trinitrotoluene (TNT)​, and 2,​4-​dinitrotoluene (DNT)​, in their acetonitrile solns. The detection limits of fluorophores to PA, TNT, and DNT proved to be in the range from 5.83 × 10-​6 to 2.38 × 10-​7 mol​/L, 1.70 × 10-​4 to 8.40 × 10-​6 mol​/L, and 8.39 × 10-​5 to 6.87 × 10-​6 mol​/L, resp. The theor. investigation into the quenching mechanism in the presence of fluorophore has been performed. All compds. have shown a good efficiency as sensor materials when tested as elements of the original device <> for detecting nitro-​contg. explosives in vapor phase

\\\\expert2\\nbo\\Analytical and Bioanalytical Chemistry\\2016, Ahead Print.pdf
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3.
Инвентарный номер: нет.
   
   C 10


   
    C-H functionalization of azines. Anodic dehydroaromatization of 9-(hetero)aryl-9,10-dihydroacridines [Electronic resource] / A. V. Shchepochkin, O. N. Chupakhin, V. N. Charushin, D. V. Steglenko, V. I. Minkin, G. L. Rusinov, A. I. Matern // RSC Advances. - 2016. - Vol. 6, № 81. - С. 77834-77840
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
HYDRIDE TRANSFER-REACTIONS -- AROMATIC-SUBSTITUTION -- NUCLEOPHILIC-SUBSTITUTION
Аннотация: Data on anodic dehydroaromatization of 9,10-dihydroacridines, bearing aryl and heteroaryl fragments, are presented. Effects of both electron-donating and electron-withdrawing substituents on the current-voltage characteristics of these compounds have been established. The experimental data proved to be in a good agreement with quantum chemical calculations. A simple and convenient method for the electrochemical conversion of dihydroacridines into the corresponding 9-(hetero)aryl-N-methylacridinium salts has been advanced

\\\\expert2\\NBO\\RSC Advances\\2016. Vol. 6, N 81. P. 77834.pdf
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4.
Инвентарный номер: нет.
   
   N 52


   
    New examples of chelating triketone-like ligands that promote formation of binuclear complexes [Electronic resource] / A. V. Pestov, L. A. Khamidullina, V. Ya. Sosnovskikh, P. A. Slepukhin, I. Puzyrev // Polyhedron. - 2016. - Vol. 106. - С. 75-83
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
cHROMAN-4-ONES -- TRIKETONE-LIKE LIGANDS -- BINUCLEAR COMPLEXES
Аннотация: The present work is to investigate of binding properties of chelating triketone-like ligands, which are able to forming of binuclear complexes. The studied compounds are able to exist in cyclic or 'close form' (phenyl substituted or unsubstituted 2-hydroxy-2-(trifluoromethyl)chroman-4-ones) as well as in their associated 'open form' (phenyl substituted or unsubstituted 1,1,1-trifluoro-4-(2-hydroxyphenyl)butan-2,4-diones). In this paper there is good evidence for the compounds are being in solid in 'close form' (pre-ligands), whereas in basic solutions and when involved in metal ion coordination sphere they are being in 'open form' (ligands). Protolytic equilibria of the compounds in aqueous ethylene glycol solutions were studied. Schemes of acid-base equilibria of these compounds were proposed. Apparent ionization constants of compounds containing electron-donor and electron-acceptor substituents in the benzene ring were determined using spectrophotometric method. The binding properties of 1,1, 1-trifluoro-4-(2-hydroxyphenyl)butan-2,4-dione towards Cu(II), Ni(II) and Co(II) were studied. The formation of 2:2 metal-ligand complexes was observed. X-ray analysis gives evidence the formation of complexes in which the ratio metal to ligand can be 1:2 and 2:2. Similar to beta-triketones the studied ligands tends to formation of binuclear complexes with transition metal ions

\\\\expert2\\NBO\\Polyhedron\\2016, v.106, p.75-83.pdf
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5.
Инвентарный номер: нет.
   
   D 46


   
    Design and Synthesis of N-Sulfonylamidines of Modafinic Acid [Electronic resource] / T. Beryozkina, V. A. Bakulev, L. Dianova, P. A. Slepukhin // Synthesis-Stuttgart. - 2016. - Vol. 48, № 7. - С. 1046-1054
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
MODAFINIL -- N-SULFONYL AMIDINES -- DAT INHIBITORS
Аннотация: A design and a convenient approach for the synthesis of novel N-sulfonyl-2-diphenylmethylsulfinylacetamidines have been demonstrated by starting from benzhydrylsulfanylacetic (BSA) acid. This approach involves a sequential amidation with amines, thionation with Lawesson's reagent, iminosulfonylation with sulfonyl azides, and oxidation of sulfide fragment with hydrogen peroxide. The key step of this transformation (reaction of thioamides with sulfonyl azides) was carried out either in ethanol or in the absence of any solvent. The synthesized compounds were tested in cells for inhibition of dopamine transporter. Among the synthesized compounds, two products were found to be in a similar range of activity as the well-known dopamine transporter inhibitor, modafinil.

\\\\expert2\\NBO\\Synthesis-Stuttgart\\2016. 48(7). 1046-1054.pdf
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6.
Инвентарный номер: нет.
   
   S 98


   
    Synthesis of New 1,3,4-Thiadiazines Capable of Inhibiting Nonenzymatic Glycosylation of Proteins [Electronic resource] / L. P. Sidorova, T. A. Tseitler, N. M. Perova, V. V. Emel’yanov, E. A. Savateeva, N. E. Maksimova, N. N. Mochul’skaya, V. A. Chereshnev, O. N. Chupakhin // Pharmaceutical Chemistry Journal. - 2015. - Vol. 49, № 8. - С. 501-505. - Bibliogr. : p. 505 (12 ref.)
ББК 61 + 54
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
   ХИМИЧЕСКИЕ НАУКИ

Кл.слова (ненормированные):
1,3,4-THIADIAZINE -- CYCLOCONDENSATION -- NONENZYMATIC GLYCOSYLATION OF PROTEINS -- THIOSEMICARBAZIDES
Аннотация: A series of new 1,3,4-thiadiazines with cycloalkylamino (cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino) groups were synthesized via cyclocondensation of α-haloacetophenones with thiosemicarbazides containing 4-cycloalkyl groups. Five of the synthesized compounds showed the capability to inhibit nonenzymatic glycosylation of proteins in vitro in a model system. The obtained test results allowed compounds containing cyclopropylamino residues (LT-1a and LT-1d) to be recommended for further in vivo testing

\\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2015, 49 (8), 501-505.pdf
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7.
Инвентарный номер: нет.
   
   A 23


   
    Aerobic oxidative C-H/C-H coupling of azaaromatics with indoles and pyrroles in the presence of TiO2 as a photocatalyst [Electronic resource] / I. A. Utepova, M. A. Trestsova, O. N. Chupakhin, V. N. Charushin, A. A. Rempel // Green Chemistry. - 2015. - Vol. 17, № 8. - С. 4401-4410. - Bibliogr. : p. 4409-4410 (30 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
BOND ACTIVATION -- INHIBITORS -- HYDROGEN
Аннотация: In this paper we wish to report a highly selective and benign method for the double C-H/C-H coupling of azaaromatics with indoles or pyrrole in the presence of air oxygen/TiO2, as an effective photocatalytic oxidative system. It has been shown that this versatile approach can be applied for direct C-H functionalisation of a variety of azaaromatic systems, such as mono-, di- and triazines, substituted and unsubstituted azines and their benzo-annelated analogues.

\\\\expert2\\nbo\\Green Chemistry\\2015, v.17, N 8, p.4401-4410.pdf
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8.
Инвентарный номер: нет.
   
   F 33


   
    Features of polychlorinated biphenyls nitration [Electronic resource] / T. I. Gorbunova, M. G. Pervova, K. A. Plotnikova, V. I. Saloutin, O. N. Chupakhin // Russian Journal of General Chemistry. - 2015. - Vol. 85, № 7. - С. 1611-1616. - Bibliogr. : p. 1616 (21 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
POLYCHLORINATED BIPHENYLS -- GAS CHROMATOGRAPHY -- NITRATION
Аннотация: Nitration of mono-, di-, and trichlorobiphenyls has been studied. The nitration degree depends on the number of chlorine substituents; one to four nitro groups can be introduced. The conclusions have been confirmed by results of nitration of the "Trikhlorbifenil" technical mixture of polychlorinated biphenyls.

\\\\expert2\\nbo\\Russian Journal of General Chemistry\\2015, V. 85, N 7, p. 1611-1616.pdf
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9.
Инвентарный номер: нет.
   


   
    Boron(III) Complexes with N,​N'- and N,​O-​Heterocyclic Ligands: Synthesis and Spectroscopic Properties [Electronic resource] / G. N. Lipunova, E. V. Nosova, V. N. Charushin, O. N. Chupakhin // Comments on Inorganic Chemistry. - 2016. - Vol. 2016. - С. 1153470
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PROPERTIES -- PREPARATION -- SYNTHETIC PREPARATION
Аннотация: This review is focused on consideration of effects of the nature of N,​N'- and N,​O-​bidentate ligands on the structure and optical properties of their B(III) complexes. It has been established that B(III) complexes with asym. N,​N'- and N,​O-​bidentate ligands, such as ortho-​hydroxyphenyl substituted azaheterocycles and heteryl-​β-​ketoimines, exhibit large Stokes shifts, enhanced intensity, and extended range for luminescence in solns. as well as in solid state, comparable with characteristics of the family of BODIPYs derivs. Complexes of some bidentate ligands can be considered as promising fluorophores for applications in biomedical imaging, electroluminescent, solar cell devices, and other fields.

\\\\expert2\\nbo\\Comments on Inorganic Chemistry\\2016. P. 1153470.pdf
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10.
Инвентарный номер: нет.
   
   C 51


   
    Chemoenzymatic Synthesis and Antiherpes Activity of 5-Substituted 4,6-Difluorobenzimidazoles Ribo- and 2′-Deoxyribonucleosides [Электронный ресурс] / M. I. Kharitonova, I. V. Fateev, A. L. Kayushin, I. D. Konstantinova, S. K. Kotovskaya, V. L. Andropova, G. A. Galegov, V. N. Charushin, A. I. Miroshnikov // Synthesis (Germany). - 2016. - Vol. 48, № 3. - С. 394-406. - Bibliogr. : p. 405-406 (37 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
DRUG DISCOVERY- -- NUCLEOSIDES -- HERPES SIMPLEX VIRUS
Аннотация: A series of 5,6-disubstituted benzimidazole nucleosides, obtained earlier, did not show any significant antiviral activity at relatively low cytotoxicity in vitro. In the course of our research we have succeeded in introducing an additional fluorine atom into the benzimidazole ring system. A new series of 4,6-difluorobenzimidazoles, bearing various groups (fluoro-, methoxy-, ethoxy-, morpholino-, and pyrrolidino-) in the 5-position of the benzene ring, have been synthesized. All these compounds proved to be substrates for recombinant E. coli purine nucleoside phosphorylase (PNP) in the transglycosylation reaction. Effective methods for the synthesis of ribo- and 2′-deoxyribonucleosides with high yields (60–90%) have been described, and the formation of regioisomeric N3-nucleosides of benzimidazoles have been detected. The biological activity of the nucleosides obtained against herpes simplex virus type 1 (HSV-1) has been elucidated. All compounds show a low cytotoxicity in the cell culture Vero E6. 4,5,6-Trifluoro-1-(β-d-ribofuranosyl)benzimidazole and 5-methoxy-4,6-difluoro-1-(β-d-2′-deoxyribofuranosyl)benzimidazole proved to inhibit completely the progression of the virus cytopathic effect (CPE) at a multiplicity of infection (MOI) of 0.01 PFU/cell.

\\\\expert2\\nbo\\Synthesis\\2016, v. 48. p.394-406.pdf
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