Центральная Научная Библиотека УрО РАН

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    Antiviral properties of verdazyls and leucoverdazyls and their activity against group b enteroviruses / A. S. Volobueva, V. V. Zarubaev, T. G. Fedorchenko [et al.] // Russian journal of infection and immunity. - 2023. - Vol. 13, № 1. - P107-118
Рубрики: ХИМИЧЕСКИЕ НАУКИ
   ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ENTEROVIRUSES -- ENTEROVIRAL INFECTION -- COXSACKIEVIRUS
Аннотация: Enteroviruses are non-enveloped viruses of Enterovirus genus, Picornaviridae family, causing a variety of human diseases: from acute respiratory and intestinal infections to more severe pathologies including poliomyelitis, encephalitis, myocarditis, pancreatitis. Currently, no approved direct-acting antiviral drugs for treatment of enterovirus infections exists, whereas vaccination is available only for prevention of poliomyelitis and enterovirus 71 infection. Therefore, it is promising to conduct a search for inhibitors of enteroviruses life cycle in drug development to treat enterovirus infections. Here, antiviral properties of stable free radicals, verdazyls, and their precursors, leucoverdazyls, were investigated. It has been shown that leucoverdazyls vs verdazyls increased the survival of permissive cell culture infected with coxsackievirus. The activity range of the lead leucoverdazyl against RNA-containing and DNA-containing human viruses (in the viral yield reduction assay) and its proposed mechanism of action (time of addition assay) was studied. The lead compound suppressed reproduction of group B enteroviruses in vitro, with modest activity against influenza A virus and no activity against herpes virus type 1 and adenovirus type 5. The maximum decrease in viral titers was observed upon its addition to infected cells during early and middle stages of the virus life cycle. Thus, we concluded that the studied compound has a pronounced inhibitory activity against group B enteroviruses not belonging to the class of capsid binder inhibitors, without virucidal properties. Previously, we described antioxidant properties of leucoverdazyls. It is known that many viral infections are accompanied by production of reactive oxygen species and oxidative stress, and some compounds with antioxidant properties exhibit antiviral potential. Targeted chemical modifications of leucoverdazyls and further studies of leucoverdazyl mechanism of action as well as in vivo animal studies are needed. However, the results obtained may be useful for future development of new antiviral drugs to treat enteroviral infections.

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   B 62


    Bis[N-(2-hydroxyethyl)-beta-alaninato]-copper(II) [Text] / A. V. Pestov, E. V. Peresypkina, A. V. Virovets, N. V. Podberezskaya, Yu. G. Yatluk, Yu. A. Skorik // Acta Crystallographica Section C: Crystal Structure Communications. - 2005. - Vol. 61, № 12. - Pm510-m512

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The CuII ion in the title complex, [Cu(C5H 10NO3)2] or [Cu(He-ala)2] [He-ala = W-(2-hydroxyethyl)-?-alaninate], resides at the inversion centre of a square bipyramid comprised of two facially arranged tridentate He-ala ligands. Each He-ala ligand binds to a CuII ion by forming one six-membered ?-alaninate chelate ring in a twist conformation and one five-membered ethanolamine ring in an envelope conformation, with Cu-N = 2.017 (2) A, Cu-OCoo = 1.968 (1) A and Cu-OOH = 2.473 (2) A. The [Cu(He-ala)2] molecules are involved in a network of O-H?O and N-H?O hydrogen bonds, forming layers parallel to the (101?) plane. The layers are connected into a three-dimensional structure by van der Waals interactions, so that the molecular centres form pseudo-face-centered close packing. © 2005 International Union of Crystallography????

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   C 21


    Carboxyalkylation of chitosan in the gel state / Yu. A. Skorik, A. V. Pestov, M. I. Kodess, Yu. G. Yatluk // Carbohydrate Polymers. - 2012. - Vol. 90, № 2. - С. 1176-1181

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CHITOSAN -- CHEMICAL MODIFICATION -- GEL TECHNIQUE
Аннотация: This study presents a new approach for direct carboxyalkylation of chitosan in the gel state by using aza-Michael addition and substitution reactions. Various reagents were applied including acrylic and crotonic acids, and alpha-, beta-, gamma-, delta-, and epsilon-halocarboxylic acids. The reaction of chitosan with gamma- and delta-halocarboxylic acids showed no target product formation either in solution or in the gel state. In the case of acrylic, crotonic, alpha- and beta-halocarboxylic acids, the reaction performed in the gel state (concentration of chitosan 20-40%) shows higher degree of substitution at lower reaction time and temperature than in diluted solutions (concentration of chitosan 0.5-2%). The results were discussed in terms of kinetics of the target and side reactions. H-1 and C-13 NMR confirmed that in all cases the carboxyalkylation of chitosan proceeds exclusively at the amino groups

\\\\Expert2\\nbo\\Carbohydrate Polymers\\2012, v. 90, p.1176.pdf
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   C 51


    Chemo-enzymatic synthesis and biological evaluation of 5,6-disubstituted benzimidazole ribo- and 2′-deoxyribonucleosides [Электронный ресурс] / I. D. Konstantinova, O. M. Selezneva, I. V. Fateev, T. A. Balashova, S. K. Kotovskaya, Z. M. Baskakova, V. N. Charushin, I. A. Mikhailopulo // Synthesis (Germany). - 2013. - Vol.45, №2, art. N SS-2012-T0784-OP. - P272-280

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
5,6-DISUBSTITUTED BENZIMIDAZOLES -- NUCLEOSIDES -- SUBSTRATE PROPERTIES
Аннотация: A number of new 5,6-disubstituted benzimidazoles have been prepared and their substrate properties for recombinant E. coli purine nucleoside phosphorylase (PNP; the product of the deoD gene) in the transglycosylation reaction were investigated. The heterocyclic bases showed good substrate activity for PNP and the ribo- and 2-deoxyribonucleosides were synthesized. The predominant (OMe and OEt) or exclusive (Oi-Pr, morpholino, and N-methylpiperazino) formation of the 5-substituted 6-fluoro-1-(β-d- ribofuranosyl)benzimidazoles was observed. The formation of the regioisomeric 6- methoxy-, 6-ethoxy-, or 6-isopropoxy-substituted 1-(2-deoxy-β-d- ribofuranosyl)-5-fluorobenzimidazoles was observed in the trans-2- deoxyribosylation reaction of the corresponding bases. The predominant or exclusive formation of the regioisomeric N1-nucleosides with bulky 5-substituents of 6-fluorobenzimidazole points to a large hydrophobic pocket in the E. coli PNP active site that can accommodate these groups. The biological activity of the synthesized nucleosides was studied and revealed no inhibitory activity against a broad variety of DNA and RNA viruses. The compounds also lacked significant cytotoxicity

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    Chemo-Enzymatic Synthesis and Biological Evaluation of 5,6-Disubstituted Benzimidazole Ribo- and 2′-Deoxyribonucleosides / I. D. Konstantinova, O. M. Selezneva, S. K. Kotovskaya, Z. M. Baskakova, V. N. Charushin, A. V. Baranovsky // Synthesis. - 2013. - Vol.45, № 2. - С. 272-280
Кл.слова (ненормированные):
5,6-DISUBSTITUTED BENZIMIDAZOLES -- NUCLEOSIDES -- PURINE NUCLEOSIDE PHOSPHORYLASE
Аннотация: A number of new 5,6-disubstituted benzimidazoles have been prepared and their substrate properties for recombinant E. coli purine nucleoside phosphorylase (PNP; the product of the deoD gene) in the transglycosylation reaction were investigated. The heterocyclic- bases showed good substrate activity for PNP and the ribo- and 2′-deoxyribonucleosides were synthesized. The predominant (OMe and OEt) or exclusive (Oi-Pr, morpholino, and N-methylpiperazino) formation of the 5-substituted 6-fluoro-1-(β-D-ribofuranosyl)benzimidazoles was observed. The formation of the regioisomeric 6- methoxy-, 6-ethoxy-, or 6-isopropoxy-substituted 1-(2-deoxy-β-D-ribofuranosyl)-5-fluorobenzimidazoles was observed in the trans-2-deoxyribosylation reaction of the corresponding bases. The predominant or exclusive formation of the regioisomeric N1-nucleosides with bulky 5-substituents of 6-fluorobenzimidazole points to a large hydrophobic pocket in the E. coli PNP active site that can accommodate these groups. The biological activity of the synthesized nucleosides was studied and revealed no inhibitory activity against a broad variety of DNA and RNA viruses. The compounds also lacked significant cy

\\\\expert2\\nbo\\Synthesis\\2013, v. 45. N 2. p. 272-280.pdf
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   C 74


    Complexation models of N-(2-carboxyethyl)chitosans with copper(II) ions [Text] / Yu. A. Skorik, C. A. R. Gomes, N. V. Podberezskaya, G. V. Romanenko, L. F. Pinto, Yu. G. Yatluk // Biomacromolecules. - 2005. - Vol. 6, № 1. - P189-195 . - ISSN 1525-7797

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The copper(II) complex formation equilibria of N-(2-carboxyethyl)chitosans with three different degrees of substitution (DS = 0.42, 0.92, and 1.61) were studied in aqueous solution by pH-potentiometric and UV-spectrophotometric techniques. It was demonstrated that the complexation model of CE-chitosans depends on DS: the [Cu(Glc-NR2)2] complexes are predominant for two lower substituted samples ("bridge model", log ?12 = 10.06 and 11.6, respectively), whereas the increase of DS leads to formation mainly of the [Cu(Glc-NR2)] complexes ("pendant model", log ?11 = 6.41). As a model for copper complexation with a disubstituted residue of CE-chitosan, the complex of N-methyliminodipropionate [CuMidp(H2O)]·(H2O) was synthesized and structurally characterized by XRD. The unit cell consists of two crystallographically nonequivalent Cu atoms having slightly distorted square pyramidal coordination; Midp constitutes the basal plane of the pyramid and acts as a tetradentate NO3 chelate-bridging ligand by the formation of two six-membered chelate rings (average Cu-O 1.99 A, Cu-N 2.04 A) and a bridge via carbonyl O atom (average Cu-O 1.99 A), an apical position is occupied by a water molecule (average Cu-Ow 2.30 A).

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   C 78


    Copper and Copper Oxides Nanopowders in the Oxidative Condensations of Phenylacetylene and Tert-Butylacetylene [Electronic resource] / O. A. Kuznetsova, E. F. Khmara, V. I. Filyakova, M. A. Uimin, A. E. Ermakov, C. K. Rhee, V. N. Charushin // Russian Journal of General Chemistry. - 2007. - Vol. 77, № 3. - P404-408. - Библиогр. : с. 408 (12 назв.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Transformations of phenylacetylene and tert-butylacetylene in the presence of copper and copper oxide (Cusub2/subO, CuO) nanopowders prepared by gas-phase condensation of copper in argon were studied. The reaction of phenylacetylene with copper oxide nanopowders having different phase compositions in the absence of a solvent at room temperature resulted in oxidative condensation of phenylacetylene and complex formation of the condensation product. The complex undergoes decomposition by the action of acids, bases, and compounds capable of forming complexes. According to the X-ray diffraction data, one of the products is a new “parquet” modification of diphenyldiacetylene. Under analogous conditions, tert-butylacetylene gave rise to a complex mixture of products among which di- tert-butyldiacetylene was identified by gas chromatography-mass spectrometry. No copper complexes with the tert-butylacetylene condensation products were detected.

\\\\expert2\\nbo\\Russian Journal of General Chemistry\\2007, V. 77, N 3, p.404.pdf
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   N 64

    Nikitin, E. D.
    Critical temperatures and pressures of 12 phthalates using the pulse-heating method [Text] / E. D. Nikitin, A. P. Popov, Yu. G. Yatluk // Journal of Chemical & Engineering Data. - 2006. - Vol. 51, № 4. - P1326-1330

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The critical temperatures and pressures of phthalates with the straight side alkyl chains C6H4-1,2-[COO(CH2) nH]2 (n is from 1 to 11) as well as bis(2-ethylhexyl) phthalate have been measured. No literature data are available for the critical properties of phthalates. Since phthalates decompose at temperatures well below their critical temperatures, the method of pulse heating of a wire probe immersed into the liquid under study has been used. The method minimizes the effect of thermal decomposition because residence times are only from (0.035 to 1) ms. The experimental critical properties of phthalates have been compared with the values calculated using the group-contribution methods by Constantinou and Gani and Marrero and Gani ??

\\\\Expert2\\nbo\\Journal of Chemical and Engineering Data\\2006, v.51, p.1326.pdf
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   C 91


    Crystal structure of N-(3-hydroxypropyl)-beta-alanine and Bis(N-(3-hydroxypropyl)-beta-alaninato)dicopper(II) [Cu2 (Pro-ala)2] [Electronic resource] / A. V. Pestov, P. A. Slepukhin, L. S. Molochnikov, M. A. Ezhikova, M. I. Kodess, Yu. G. Yatluk // Russian Journal of Inorganic Chemistry (Zhurnal Neorganicheskoi Khimii). - 2010. - Vol. 55, № 2. - P201-208

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: N-(3-Hydroxypropyl)-beta-alanine was synthesized by the reacti on of 3-aminopropanol with acrylic acid. From this ligand and basic copper carbonate, bis(N-(3-hydroxypropyl)-beta-alaninato)dicopper(II) [Cu2 (C6H11NO3)2] was obtained. The structures of the chelating agent and the copper complex were studied by X-ray diffraction. The Cu(II) coordination polyhedron is a distorted square pyramid. Each ligand forms six-membered ?-alaninate and propanolamine chelate rings. The propoxy group functions as a bridge. In the crystal structure, the molecules form intermolecular coordination bonds C=OCu, which are perpendicular to the layers. The EPR signal typical of dimeric copper complexes is not observed due to low occupancy of the excited paramagnetic triplet state. The weak paramagnetic signal from monomeric copper complex allowed recording of the 1H NMR spectrum of [Cu2 (Pro-ala) 2] with characteristic line broadening and contact shift. It follows from the obtained data that on dissolution, the complex dissociates by 40% to give monomeric copper complexes

\\\\Expert2\\nbo\\Russian Journal of Inorganic Chemistry\\2010, v. 55, N 2, с.201.pdf
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10.

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   E 27


    Effects of a compound from the group of substituted thiadiazines with hypothermia inducing properties on brain metabolism in rats, a study in vivo and in vitro / O. B. Shevelev, N. B. ILLARIONOVA, D. V. Petrovski, A. P. Sarapultsev, O. N. Chupakhin, M. P. Moshkin // PLOS ONE . - 2017. - Vol. 12, № 7. - С. е0180739[1-12]

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ГИПОТЕРМИЯ -- HYPOTHERMIA -- 1,3,4-THIADIAZINE -- МЕТАБОЛИТЫ МОЗГА -- BRAIN METABOLITES -- ТЕРМОРЕГУЛЯЦИЯ -- THERMOREGULATION
Аннотация: The aim of the present study was to examine how administration of a compound of 1,3,4-thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine, hydrobromide (L-17) with hypothermia inducing properties affects the brain metabolism. The mechanism by which L-17 induces hypothermia is unknown; it may involve hypothalamic central thermoregulation as well as act via inhibition of energy metabolism. We tested the hypothesis that L-17 may induce hypothermia by directly inhibiting energy metabolism. The study in vivo was carried out on Sprague-Dawley adult rats. Two doses of L-17 were administered (190 mg/ kg and 760 mg/kg). Brain metabolites were analyzed in control and treated groups using magnetic resonance spectroscopy, along with blood flow rate measurements in carotid arteries and body temperature measurements. Further in vitro studies on primary cultures from rat hippocampus were carried out to perform a mitochondria function test of L-17 preincubation (100 μM, 30 min). Analysis of brain metabolites showed no significant changes in 190 mg/kg treated group along with a significant reduction in body temperature by 1.5ÊC. However, administration of L-17 in higher dose 760 mg/kg provoked changes in brain metabolites indicative of neurotoxicity as well as reduction in carotid arteries flow rate. In addition, a balance change of excitatory and inhibitory neurotransmitters was observed. The L-17 pre-incubation with cell primary cultures from rat brain showed no significant changes in mitochondrial function. The results obtained in the study indicate that acute administration of L-17 190 mg/kg in rats induces mild hypothermia with no adverse effects onto brain metabolism.

\\\\Expert2\\NBO\\PLoS ONE\\2017 V. 12 N 7 p. e0180739.pdf
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11.

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   E 97


    Exchange Interactions in Cobalt(II) and Nickel(II) Complexes Containing M-4(mu(3)-OH)(2) Metal Cores with Distorted Rhombic Topology [Electronic resource] / A. Golberg, G. G. Aleksandrov, A. S. Bogomyakov, M. A. Kiskin, S. V. Kolotilov, I. A. Utepova, A. A. Sidorov, O. N. Chupakhin, I. L. Eremenko // Theoretical and Experimental Chemistry . - 2015. - Vol. 50, № 6. - С. 364-370. - Bibliogr. : p. 369-370 (21 ref.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PENTANUCLEAR COMPLEX -- COBALT(II) -- TETRANUCLEAR COMPLEX
Аннотация: Antiferromagnetic interactions between the Co2+ or Ni2+ ions were found in complexes [(mu(3) aEuroaEuro parts per thousand L)(2)Co (5) (II) (mu aEuroaEuro parts per thousand OH)(2)(Piv)(7)(NO3)] and [(mu(3) aEuroaEuro parts per thousand L)(2)(HPiv)Ni (4) (II) (mu(3) aEuroaEuro parts per thousand OH)(2)(Piv)(4)(NO3)(2)] (Piv(-) = pivalic acid anion, L = 1,1'-dipyridazinylferrocene) possessing a metal core with distorted rhombic topology M-4(mu(3)-OH)(2). In contrast to the case of symmetrical analogs, the signs of all the exchange interaction parameters J were determined unambiguously.

\\\\expert2\\nbo\\Theoretical and Experimental Chemistry\\2015, V.50, № 6, p.364-370.pdf
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12.

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    Shishmakov, A. B.
    Few-step synthesis of PdO/TiO2 and Pd/TiO2 xerogels / A. B. Shishmakov, Yu. V. Mikushina, O. V. Koryakova // Inorganic Materials. - 2021. - Vol. 57, № 2. - P164-170
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
XEROGEL -- TITANIUM DIOXIDE -- PALLADIUM
Аннотация: We demonstrate a few-step technique for the synthesis of PdO/TiO2 and Pd/TiO2 (0.1–2.0 wt % Pd) xerogels, which comprises hydrolysis of a palladium nitrate solution in titanium tetrabutoxide in the vapor atmosphere over an aqueous acetic acid solution, drying, and calcination of the material between 800 and 870°C. According to X-ray diffraction and electron microscopy characterization results, after calcination at 800°C the xerogels contained palladium in the form of PdO particles ≤3–5 nm in size. The highly dispersed palladium(II) oxide covered the surface of the rutile crystallites and filled pores in between. Throughout the range of Pd(NO3)2 concentrations studied, the PdO particles were identical in size. In the material calcined at 870°C, palladium had the form of metallic particles ranging in diameter from 55 to 420 nm. Raising the palladium nitrate concentration in titanium tetrabutoxide was shown to increase the average size of the Pd particles.

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13.

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   F 70


    Fluorinated derivatives of benz[4,5]imidazo[2,1-b][1,3]thiazoles are inhibitors of measles viruses [Электронный ресурс] / A. G. Pokrovskii, E. A. Il"ichyova, S. K. Kotovskaya, S. A. Romanova, V. N. Charushin, O. N. Chupakhin // Doklady Akademii Nauk . - 2004. - Vol.398, №3. - P412-414

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRAL ACTIVITY -- CYTOTOXICITY -- FLUORINATED BENZIMIDAZOLES
Аннотация: The results of in vitro anti-virus activity investigation for the new benzimidazoles (their synthesis is reported previously) are presented. The activity of the most active compound was studied in dependence of its introduction to the culture (before virus adsorption, simultaneously with virus, directly after virus adsorption, after 6 hours and after 1 day). Preliminary treatment of cells didn't protect them from further infecting; therewith the compound introduction simultaneously with virus or after infection caused no considerable effect on its anti-virus activity. The latter is attributed to blocking of late stages of measles virus reproduction - synthesis or arrangement of virus proteins

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14.

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    Functionalized trifluoromethyl-containing lithium β-diketonate in the synthesis of homo- and heteronuclear complexes of rare-earth metals / Yu. S. Kudyakova, P. A. Slepukhin, I. N. Ganebnykh [и др.] // Russian Journal of Coordination Chemistry. - 2021. - Vol. 47, № 4. - P280-295
Кл.слова (ненормированные):
β-DIKETONATES -- LANTHANIDES -- 19F NMR SPECTROSCOPY -- MASS SPECTROMETRY
Аннотация: The reactions of functionalized lithium CF3-β-diketonate (LiL) with trivalent rare-earth metal salts in methanol afford homobinuclear and heterobi(tri)nuclear complexes depending on the nature of the transition metal and anion (chlorides, nitrates, and acetates). In the cases of lanthanum(III) and cerium(III), homoleptic complexes [(LnL3)2] are isolated (CIF files CCDC nos. 2031097 (Ia) and 2031102 (Ib)). The reaction of LiL with praseodymium(III) nitrate gives the new trimetallic structure [(LiPrL3)(LiL)(NO3)(H2O)2] (CIF file CCDC no. 2031103 (II)), and the replacement of nitrate by chloride gives [(PrL3)(LiL)(H2O)] (CIF file CCDC no. 2031104 (IIIa)). Regardless of the nature of the anion of the salt in the series from neodymium(III) to ytterbium(III) and yttrium(III), Ln–Li β-diketonates [(LnL3)(LiL)(solv)] (solv is H2O and MeOH) are formed, and their structures are characterized by X-ray structure analysis (CIF files CCDC nos. 2031099 (IIIb), 2031100 (IIIc), 2031098 (IVa), 2031096 (IVc), 2031094 (IVf), 2031101 (IVg), and 2031095 (IVh)). The equilibrium of the diketonate isomeric forms in a solution of deuterated dimethyl sulfoxide is studied by 19F NMR spectroscopy, and the qualitative composition of the polynuclear complexes is determined by mass spectrometry.

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15.

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    Influence of trifluoromethyl groups on the crystal packing of the binuclear copper(ii) complex based on N2O3-pentadentate (hydroxy)bis(СF3-enaminoketone) / Y. O. Edilova, Yu. S. Kudyakova, P. A. Slepukhin [et al.] // Russian Journal of Coordination Chemistry. - 2021. - Vol. 47, № 9. - P631-637
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ENAMINOKETONES -- SCHIFF BASES -- BINUCLEAR COPPER(II) BASES -- X-RAY STRUCTURE ANALYSIS
Аннотация: The reaction of 1,1,1-trifluoro-4-methoxy-3-penten-2-one (L1) with 1,3-diaminopropan-2-ol affords N,N'-(2-hydroxypropane-1,3-diyl)bis(trifluoroacetylacetimine) (H3L2) in a yield of 82%. In the absence of additional bases, the synthesized N2O3 ligand reacts with copper(II) acetate to give the binuclear complex [Cu2L2(OAc)] (I), the structure of which is determined by X-ray structure analysis (CIF file CCDC no. 2071133).

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16.

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   I-69


    Interaction of fluoroalkyl-containing beta-diketones with amines [Electronic resource] / V. I. Filyakova, V. G. Ratner, N. S. Karpenko, K. I. Pashkevich // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 1996. - Vol. 45, № 9. - P2163-2168

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The composition of products of the interaction of asymmetric fluoroalkyl-containing -diketones with amines was studied. Mixtures of regioisomeric -aminovinylketones and products of cleavage and secondary condensation are formed, depending on the temperature, the solvent, the nature of the fluorinated and nonfluorinated substituents in the -diketone, and the basicity of the amine. The major product is a -aminovinylketone in which the NH2 group is removed from the fluoroalkyl substituent. No -aminovinylimines, products of condensation involving two electrophilic centers, were observed

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\1996, 45 (9), 2163.pdf
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17.

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    Mechanochemical synthesis of coumarins via Pechmann condensation under solvent-free conditions: an easy access to coumarins and annulated pyrano[2,3-f] and [3,2-f]indoles / A. D. Sharapov, R. F. Fatykhov, I. A. Khalymbadzha [и др.] // Green Chemistry. - 2022. - Vol. 24, № 6. - P2429-2437
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
A green protocol has been developed for the synthesis of simple coumarins and linear pyrano[2,3-f] and [3,2-f]indoles by the reaction of phenol derivatives with β-ketoesters under ball milling at ambient temperature in the presence of methanesulfonic acid as a mild acid catalyst. The significant advantages of this procedure are high yields, scalability, no use of hazardous acids or solvents, shorter reaction time, ambient temperature, low cost, and straightforward purification without column chromatography. This procedure is associated with high EcoScale metrics and a low E-factor. In contrast to traditional Pechmann condensation procedures, the mechanochemical protocol leads to the synthesis of pyranoindoles with excellent regioselectivity and high yields.

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18.

Инвентарный номер: нет.

   M 78


    Modeling of the biphenyl dioxygenase α-subunit structure of rhodococcus strains and features of the destruction of chlorinated and hydroxylated biphenyls at different temperatures / D. O. Egorova, T. I. Gorbunova, T. D. Kir’yanova [et al.] // Applied Biochemistry and Microbiology. - 2021. - Vol. 57, № 6. - P732-742

ББК Г
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
RHODOCOCCUS -- BIPHENYL DIOXYGENASE -- 3,4-DICHLOROBIPHENYL -- HYDROXYBIPHENYL
Аннотация: Based on modeling of the protein structure of the α subunit of biphenyl 2,3-dioxygenase (BphA1) (EC 1.14.12.18), the key enzyme for the destruction of biphenyl and polychlorinated biphenyls (PCBs), it was found that BphA1 Rhodococcus wratislaviensis KT112-7 (= VKM Ac-2623D) had the highest level of similarity with classical biphenyl dioxygenases (BDOs) of the PCBs-degrader strains of the genus Rhodococcus. The structure of BphA1 Rhodococcus wratislaviensis CH628 had the highest similarity with naphthalene dioxygenase of the strains of the genus Rhodococcus, and the structure of BphA1 Rhodococcus ruber P25 (= IEGM 896) was unique, since no protein molecules with a high level of similarity were identified. It was shown that all of the studied strains, despite their differences in the BphA1 structure, carried out dioxygenation of the unsubstituted ring in molecules of 3,4-dichlorobiphenyl (PCB 12), as well as monochlorinated and monohydroxy-monochlorinated biphenyls (mixture P). The level of destruction of PCB 12 and mixture P was 95.4–100% at 30°C for 10 days at an initial concentration of 0.1 g/L. It was found that a change in temperature (10–50°C) had the greatest effect on the biodegradative activity of the strain R. ruber P25 (a decrease by 3.1–3.9 times). R. wratislaviensis CH628 and R. wratislaviensis KT112-7 efficiently degraded PCB 12 at temperatures of 20–40 and 10–30°C, respectively (the destruction level was 93.2–100%).

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19.

Инвентарный номер: нет.

   M 78


    Modulation of inflammatory response improves myocardial infarct healing in rats / A. Sarapultsev, O. N. Chupakhin, P. Sarapultsev, M. T. Abidov, I. Danilova // Current Pharmaceutical Design . - 2014. - Vol.20, №12. - С. 1980-1986

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
INFLAMMATION -- L-17 COMPOUND -- MYOCARDIAL INFARCTION
Аннотация: It is reputed that the ideal therapeutic approaches to treatment of patients with acute coronary syndrome (ACS) and myocardium infarction (MI) should be aimed at the inflammation reaction triggers. This study investigated the effectiveness of the impact of L-17 compound of the group of 5- phenyl substituted-6H-1,3,4-thiadiazine-2-amines upon the course of experimental MI as compared to the impact of a preparation, officially registered in Russia as an immunomodulator, Tamerit, belonging to phthalhydrazid derivative substance. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections and biochemical analysis has been carried out at the 1st and 7th days of the experimental MI. The conducted investigations have shown that under the action of immunocorrectors the inflammation reaction character changes, exudative/destructive inflammation is replaced by a proliferative-cellular one. Animals' blood biochemical analysis at the background of L-17 and Tamerit introduction has shown a decrease of aminotransferases and lactatedehydrogenases activity in blood as compared to the reference group of animals' indicators, which is evidently caused by epicardial injury of myocardium and lesser amount of the alternative cardiomyocytes. At the same time, no noticeable difference in biochemical characteristics in groups, having been treated to immunomodulators of different chemical composition was identified, which is the sign of the essential similarity of their impact. Thus, immunocorrectors of different chemical groups (Tamerit and compound L17) diminish the volume of initial myocardial infarction and accelerate the granulation processes in course of MI, and represent a new category of treatment agents

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20.

Инвентарный номер: нет.



    Platinum(II) acetylacetonate complex based on 5-(3-aminophenyl)-2-(2-thienyl)pyridine: synthesis, crystal structure, and photophysical properties / D. S. Kopchuk, P. A. Slepukhin, O. S. Taniya [et al.] // Russian Journal of Coordination Chemistry. - 2022. - Vol. 48, № 7. - P430-435
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The Pt(II) acetylacetonate complex [(L)Pt(Acac)] based on aminophenyl-substituted 2-(2-thienyl)pyridine (L) was synthesized, its photophysical properties were studied and compared with these properties for a similar complex containing no amino group in the ligand. The structure of the complex was confirmed by X-ray diffraction (CIF file CCDC no. 2144689), 1H and 13C NMR spectroscopy, ESI mass spectrometry, and elemental analysis.

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21.

Инвентарный номер: нет.

   S 43


    Secondary structure of the M2 protein of type-A influenza-virus and its role in rimantadine and deytiforine resistanse [Text] / O. I. Kiselev, V. P. Mishin, V. I. Eroshkin, K. N. Kizeletskaya, E. V. Usova, V. I. Rudenko, O. N. Chupakhin // Molecular Biology. - 1994. - Vol. 28, N 5. - P650-653

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Studies on the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow purposeful design of new compounds having a broad spectrum of antiviral activity and evoking no resistance

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22.

Инвентарный номер: нет.

   S 90


    Study of the inf luence of the alkyl ester group in (S)-valinates on diastereoselectivity of their condensation with N-acetylphenylalanine by the mixed anhydride method [Electronic resource] / E. A. Zhdanova, N. Z. Solieva, L. Sh. Sadretdinova, M. A. Ezhikova, M. I. Kodess, V. P. Krasnov // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2006. - Vol. 55, № 5. - P925-927. - Bibliogr. : p. 927 (15 ref.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
5(4H)-OXAZOLONES -- AMINO ACIDS -- DIASTEREOSELECTIVITY -- DIPEPTIDES -- DYNAMIC KINETIC RESOLUTION -- RACEMIZATION
Аннотация: The dynamic kinetic resolution in the synthesis of alkyl N-acetylphenylalanyl (S)-valinates was studied by the mixed anhydride method. The structure of the ester group of the amino component appeared to exert no substantial effect on the diastereoselectivity of the reaction.

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2006, 55 (5), 925.pdf
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23.

Инвентарный номер: нет.

   S 91


    Substituent effect on the stereoselectivity of acylation of racemic heterocyclic amines with N-phthaloyl-3-aryl-(S)-alanyl chlorides [Text] / G. L. Levit, D. A. Gruzdev, V. P. Krasnov, E. N. Chulakov, L. Sh. Sadretdinova, M. A. Ezhikova, M. I. Kodess, V. N. Charushin // Tetrahedron: Asymmetry . - 2011. - Vol. 22, № 2. - P185-189. - Bibliogr. : p. 189 (17ref.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The acylative kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2,3-dihydro-3-methyl-4H-1,4-benzoxazine using acyl chlorides of N-phthaloyl-(S)-phenylalanine, N-phthaloyl-3-(4-nitrophenyl)-(S)-alanine and N-phthaloyl-O-methyl-(S)-tyrosine as chiral resolving agents has been carried out. It is shown that the effectiveness of an acylative kinetic resolution depends on the electronic effects of substituents in the phenyl fragment of the acylating agent and increases as the electron-donating properties of the para-substituent (OMe H NO2) in phenyl fragment of N-phthaloyl-3-aryl-(S)-alanyl chlorides increase; conducting the process at a reduced temperature also contributes to an enhancement of the kinetic resolution

\\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2011, v. 22, p.185.pdf
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24.

Инвентарный номер: нет.

   S 98


    Synthesis and antimicrobial activity of silicon-titanium-zinc- and silicon-titanium-boron-containing glycerohydrogels / T. G. Khonina, E. Yu. Nikitina, E. V. Shadrina [et al.] // Russian chemical bulletin. - 2021. - Vol. 70, № 5. - P967-974

ББК Г
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Novel pharmacologically active silicon—titanium—zinc- and silicon—titanium—boron-containing glycerohydrogels were synthesized by the sol—gel method using silicon, titanium, zinc, and boron glycerolates as biocompatible precursors. The compositions and structural features of the hydrogels were studied by transmission electron microscopy, scanning electron microscopy, IR spectroscopy, atomic emission spectrometry, and elemental analysis methods. The disperse phase and liquid water—glycerol medium of the hydrogels were isolated by cold exhaustive extraction with ethanol and characterized. The 3D polymeric network of the gels is formed by the products of hydrolysis and subsequent (co)condensation of silicon-/silicon—boron-containing precursors. Titanium and zinc glycerolates undergo no hydrolytic transformations under gelation conditions and exist in the cells of the 3D polymeric network in the form of amorphous nanoparticles that are not linked to the network by covalent bonds. Models of the structures were proposed. The gels are characterized by antimicrobial activity, which is more pronounced for the silicon—titanium—boron-containing gel, and they can be considered as promising drugs for topical treatment prepared by the simple, environmentally friendly, and cost-effective method.

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25.

Инвентарный номер: нет.

   S 98


    Synthesis and antiviral activity of 2-amino-3-ethoxycarbonylpyrazine derivatives [Electronic resource] / V. L. Rusinov [et al.] // Pharmaceutical Chemistry Journal. - 2005. - Vol. 39, № 12. - P630-635. - Библиогр. : с. 635 (6 назв.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: A series of substituted 2-amino-3-ethoxycarbonylpyrazines containing indole, resorcinol, thiophenol, ethyl cyanoacetate, indandione, and antipyrine moieties was obtained via reactions of nucleophilic substitution of hydrogen in the initial 2-aminopyrazine-1-oxides. Some of the synthesized compounds inhibit the reproduction of measles viruses and exhibit a weak antiviral activity with respect to Marburg virus. However, most of the new substituted pyrazines are not cytotoxic and exhibit no activity against ortho-poxviruses and measles viruses.

\\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2005, 39 (12), 630.pdf
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26.

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    Synthesis and physicochemical properties of nanostructured TiO2 with enhanced photocatalytic activity / I. B. Dorosheva, A. A. Valeeva, A. A. Rempel [et al.] // Inorganic Materials. - 2021. - Vol. 57, № 5. - P503-510
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
TITANIUM DIOXIDE -- SOL–GEL METHOD -- PHOTOCATALYSIS
Аннотация: Nanostructured titanium dioxide (TiO2) with a crystallite size from 10 to 85 nm, photocatalytically active for organic reactions under illumination with visible light, has been prepared by a sol–gel process using a titanium tetrabutoxide solution in ethanol with an initial pH of 6. According to X-ray diffraction characterization results, the as-prepared titanium dioxide was amorphous. Annealing in a hydrogen atmosphere for 1 h at 400°C led to the formation of an anatase phase, and annealing in the temperature range from 600 to 800°C resulted in the anatase–rutile phase transition. The crystallite size of titanium dioxide increased from 10 to 75 nm as the annealing temperature was raised from 400 to 1000°C (furnace annealing for 1 h) and from 60 to 85 nm as the annealing time at a temperature of 800°C was increased from 30 to 240 min. Diffuse reflection spectra showed that the band gap of TiO2 decreased from 3.3 to 2.6 eV as the annealing temperature was raised from 200 to 1000°C. The specific surface area data obtained by BET measurements showed that the samples annealed at the highest temperature (1000°C) had the smallest surface area, which dropped from 307 to 1m2/g. The efficiency of the synthesized TiO2 tested as a catalyst for oxidative S H N cross-coupling of acridine with indole demonstrated an in crease in product yield from 35 to 80% as the annealing temperature was raised to 800°C. Varying the 800°C annealing time from 30 to 180 min had no effect on the reaction product yield, which ranged from 70 to 80%.

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27.

Инвентарный номер: нет.

   S 98


    Synthesis and structures of pyridoannelated 1,2,3,4-tetrazine 1,3-dioxides [Electronic resource] / V. A. Tartakovsky, I. E. Filatov, A. M. Churakov, S. L. Ioffe, Yu. A. Strelenko, V. S. Kuzmin, G. L. Rusinov, K. I. Pashkevich // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2004. - Vol. 53, № 11. - P2577-2583

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Treatment of 2- and 4-amino-3-(tert-butyl-NNO-azoxy)pyridines with nitrating agents (N2O5or NO2BF4) afforded the first representatives of pyridoannelated 1,2,3,4-tetrazine di-N-oxides, viz., pyrido[2,3-e][1,2,3,4]tetrazine 1,3-dioxide (9), 7-nitropyrido[2,3-e][1,2,3,4]tetrazine 1,3-dioxide (10), and pyrido[3,4-e][1,2,3,4]tetrazine 2,4-dioxide (11). These compounds were studied by 1H, 13C, and 14N NMR spectroscopy. The 1:1 complex of compound 10 with benzene was studied by X-ray diffraction analysis.

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2004, 53 (11), 2577.pdf
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28.

Инвентарный номер: нет.

   S 98


    Synthesis of (2s,4s)-4-phenylamino-5-oxoproline derivatives [Text] / I. A. Nizova, V. P. Krasnov, G. L. Levit, M. I. Kodess // Amino Acids. - 2002. - Vol. 22, № 2. - P179-186. - Bibliogr. : p. 186 (5 ref.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
AMIDES -- PEPTIDES -- AMINO ACIDS -- PYROGLUTAMIC ACID -- NMR SPECTROSCOPY -- PROTECTING GROUPS
Аннотация: The paper describes the synthesis of (2S,4S)-4-(N-Ts)- and (2S,4S)-4-(N-Boc)-phenylamino-5-oxoprolines (pyroglutamic acid). These derivatives have been shown to be useful for synthesis of their amides and peptides in spite of steric hindrances caused by bulky groups adjacent to the reaction centre. Under the conditions applied no lactam ring opening and no loss of stereochemical integrity of any of the chiral centres were observed, which has been confirmed by NMR techniques.

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29.

Инвентарный номер: нет.

   S 98


    Synthesis, structures, and magnetic properties of crystals of dinuclear copper(II) and cobalt(II) complexes with 3-(3,5-dimethylpyrazol-1-yl)-6-R-1,2,4,5-tetrazines [Electronic resource] / E. V. Cherdantseva, D. V. Starichenko, P. A. Slepukhin, R. I. Ishmetova, Yu. N. Shvachko, A. V. Korolev, G. L. Rusinov, V. V. Ustinov, A. I. Matern, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2010. - Vol. 59, № 4. - P717-723

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
DINUCLEAR COMPLEXES -- SPIN MAGNETISM -- TETRAZINES
Аннотация: Dinuclear complexes of CuII with 3-(3,5-dimethylpyrazol-1-yl)-6-(2-hydroxyethylami-no)-1,2,4,5-tetrazine (1) and CoII with 3-(3,5-dimethylpyrazol-1-yl)-6-(piperidin-1-yl)-1,2,4,5- tetrazine (2) were synthesized and structurally characterized, and the magnetic (SQUID) and resonance (EPR) properties of van der Waals crystals based on these complexes were studied. Unusual behavior of the effective magnetic moment ?eff(T) is observed at T < 60 K. A nonmonotonic increase in eff() for 1 (s~6 %) and a 20% reduction of eff for 2 have a common origin and are due to the influence of spin-orbital coupling on the character of the splitting between the t2g and eg levels of the central ion. Distortions of the coordination site “switch on” a positive (1) or negative (2) contribution of the orbital magnetic moment near 6 K. Irreversible temperature behavior of eff(T) in the heating and cooling regimes in the vicinity of 60 K suggests that the character of structural distortions and the magnetic properties are related to ligand geometry. This factor plays a significant role in crystal engineering of magnetoactive structures with polynitrogen ligands

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2010, 59 (4), 717-723.pdf
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30.

Инвентарный номер: нет.

   T 44


    The correctional modification of inflammatory response at the experimental acute pancreatitis / A. Sarapultsev, O. N. Chupakhin, M. Rantsev, P. Sarapultsev, I. Danilova, S. Medvedeva, L. P. Sidorova // Advances in Bioscience and Biotechnology. - 2012. - Vol.3, №4A. - С. 442-448. - Bibliogr.: p. 447-448 (26 ref.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
L-17 COMPOUND -- EXPERIMENTAL mODEL -- INFLAMMATION
Аннотация: This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2-1,3,4- thiadiazine-2-amines on the possibility of inflammatory reaction evolvement correction in experimental acute pancreatitis. The study was based upon recent clinical and experimental work which demonstrated the role of local and systemic inflammatory reactions in pancreatonecrosis. Pancreatonecrosis modeling in rats was performed in accordance with the author’s modification of ligation model of acute pancreatitis. The biochemical and hematological analysis were performed in all groups at day 1. For microscopic analysis, five histological slices of each animal were analyzed. The main group, consisting of 15 animals with the average body weight 223 g each, got intraperitoneal injection of L-17 compound, dozed 40 mg/kg in an hour after surgery of pancreatitis formation. Later on, a 40 mg/kg doze of L-17 compound was repeatedly injected as often as once every 24 hours. Already during the 1st day of the experiment, no leucopenia was observed and the signs of proliferative inflammation were detected. Later, at the background of L-17 compound introduction (5th day of the experiment) the necrosis area got surrounded by demarcation bank, and further on (by the 7th day) had been entirely replaced by granulation tissue. Thus, the application of L-17 compound in experimental acute pan-creatitis results in replacement of destructive purulent inflammation by exudative-proliferative one, prevents lympho- and monocytopenia development, minimizes amylase and pancreatic ferments level during the first day of development of the disease and cuts down the lethality rate as result of pancreatonecrosis complications tw

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