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Труды сотрудников Института горного дела УрО РАН
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Труды сотрудников Института теплофизики УрО РАН
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Труды сотрудников ЦНБ УрО РАН
Публикации Черешнева В.А.
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Каталог библиотеки ИГД УрО РАН
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 Найдено в других БД:Каталог книг и продолжающихся изданий (4)Публикации Черешнева В.А. (1)Публикации Чарушина В.Н. (3)Каталог библиотеки ИЭРиЖ УрО РАН (4)
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Общее количество найденных документов : 12
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 1-10    11-12 
1.
Инвентарный номер: нет.
   
   L 79

   
    Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors / A. R. Tsygankova, D. A. Gruzdev, V. V. Kanygin [et al.] // Mendeleev Communications. - 2021. - Vol. 31, № 5. - P659-661
ББК Г
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
AMIDE -- CLOSO-CARBORANES -- LIPOSOMES -- U87 TUMOR MODEL -- TOXICITY -- BIODISTRIBUTION
Аннотация: Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.

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2.
Инвентарный номер: нет.
   
   S 85

   
    Stnthesis, toxicity, and percutaneous activity of silicon glycerolates and related hydrogels [Electronic resource] / T. G. Khonina, O. N. Chupakhin, L. P. Larionov, T. G. Boyakovskaya, A. L. Suvorov, E. V. Shadrina // Pharmaceutical Chemistry Journal. - 2008. - Vol. 42, № 11. - P609-613 : il. - Bibliogr. : p. 612 (12 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
SILICON -- SILICON GLYCEROLATES -- HYDROGELS -- SYNTHESIS -- TOXICITY -- PERCUTANEOUS ACTIVITY

\\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2008, 42 (11), 609.pdf
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3.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and Antitubercular Evaluation on Novel 1-Ethyl-5-(hetero)aryl- 1,6-dihydropyrazine-2,3-dicarbonitriles and 3-Cyano-1-ethyl-5-(hetero) aryl-2(1H)-pyrazinones / M. A. Kravchenko, E. V. Verbitskiy, S. N. Skornyakov, P. A. Slepukhin, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // Anti-Infective Agents. - 2016. - Vol. 14, № 2. - С. 139-144
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRAZINES -- ANTITUBERCULOSIS ACTIVITY -- 2(1H)-PYRAZINONE
Аннотация: A simple method based on hydrolysis of 2,3-dicyanopyrazinium salts has been used for the synthesis of the corresponding 5-(hetero)aryl-3-cyano-1-ethyl-2(1H)-pyrazinones. Also, the series of novel 1-ethyl-5-(hetero)aryl-1,6-dihydropyrazine-2,3-dicarbonitriles have been obtained through reduction of the same pyrazinium salts with triethylsilane. The obtained compounds proved to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv, Mycobacterium avium, Mycobacterium terrae, as well as against rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The data for acute in vivo toxicity in mice have been obtained for these compounds which appear to be promising antitubercular agents

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4.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis and antituberculosis activity of novel 5-styryl-4-(hetero)aryl-pyrimidines via combination of the Pd-catalyzed Suzuki cross-coupling and SNH reactions [Electronic resource] / M. A. Kravchenko, E. V. Verbitskiy, I. D. Medvinskiy, G. L. Rusinov, V. N. Charushin // Bioorganic and Medicinal Chemistry Letters. - 2014. - Vol. 24, №14. - С. 3118-3120
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINE -- ANTIMICOBACTERIAL -- TUBERCULOSIS
Аннотация: Combination of the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (SNH) reactions proved to be a convenient method for the synthesis of 5-styryl-4-(hetero)aryl substituted pyrimidines from commercially available 5-bromopyrimidine. All intermediate 5-bromo-4-(hetero)aryl substituted pyrimidines and also the targeted 5-styryl-4-(hetero)arylpyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv, avium, terrae, and multi-drug-resistant strain isolated from tuberculosis patients in Ural region (Russia). It has been found that some of these compounds possess a low toxicity and have a bacteriostatic effect, comparable and even higher with that of first-line antituberculosis drugs

\\\\expert2\\nbo\\Bioorganic and Medicinal Chemistry Letters\\2014, v. 24, p. 3118.pdf
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5.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis of hydrogels based on silicon polyolates [Electronic resource] / T. G. Khonina, E. V. Shadrina, A. A. Boyko, O. N. Chupakhin, L. P. Larionov, A. A. Volkov, V. D. Burda // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2010. - Vol. 59, № 1. - P75-80
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
ORGANOSILICON COMPOUNDS -- DIOLS -- GLYCEROL
Аннотация: Biologically active hydrogels based on silicon polyolates, which are the products of reactions of tetraethoxy- and methyltriethoxysilanes with polyols (1,2-propanediol, glycerol, polyethylene glycol), were synthesized. The optimal conditions for hydrogel formation and hydrogel composition were determined. The acute toxicity and transcutaneous and wound-healing activities of the synthesized compounds were studied. The experimental results show that hydrogels based on silicon polyolates can be recommended for further preclinical and clinical tests with the purpose of their use in medical practice both as self-sufficient agents and ointment bases of pharmaceutical compositions with wound-healing, regenerative, and transcutaneous action

\\\\Expert2\\nbo\\Russian Chemical Bulletin\\2010, 59 (1), 75-80.pdf
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6.
Инвентарный номер: нет.
   

   
    Synthesis, characterization, and in vitro assessment of cytotoxicity for novel azaheterocyclic nido-carboranes – Candidates in agents for boron neutron capture therapy (BNCT) of cancer / M. V. Varaksin, L. A. Smyshliaeva, V. L. Rusinov [et al.] // Tetrahedron. - 2021. - Vol. 102. - P132525
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
AZAHETEROCYCLES -- BNCT -- CYTOTOXICITY -- CARBORANES
Аннотация: A series of novel water-soluble azaheterocyclic derivatives of nido-carborane bearing quinoxaline, 2H-imidazole or 1,2,4-triazine moieties were first synthesized in 82–91% yields. The structures of these boron-enriched compounds were confirmed by the data of NMR, IR spectroscopy, and mass spectrometry. To access the toxicity level for these organoboron compounds, the cytotoxicity indexes (IC50) were determined using by the MTT test on both human glioblastoma cell A-172 (IC50 = 150–243 μM) and human embryonic lung cells (IC50 = 424–944 μM) lines. The obtained preliminary results from in vitro analysis enable the synthesized water-soluble azaheterocyclic carboranes to be considered as challenging candidates in the design of agents for boron-neutron capture therapy (BNCT) of malignant tumors.

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7.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, structure, tuberculostatic activity, and toxicity of fluoroalkyl-containing 3-hydroxyimino-1,5-benzodiazepines [Electronic resource] / O. G. Khudina, Ya. V. Burgart, M. A. Kravchenko, V. I. Saloutin // Pharmaceutical Chemistry Journal. - 2011. - Vol. 45, № 2. - P75-78. - Bibliogr. : p. 78 (11 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: An improved method for the synthesis of fluoroalkyl-containing 3-hydroxyimino-1,5-benzodiazepines is proposed. For this, 3-hydroxyimines were obtained via nitrosation of 1,3-diketones and 3-oxoesters by tert-butylnitrite in diethylether under acid catalysis conditions and were reacted without isolation and further purification with ortho-phenylenediamine. It was found that polyfluoroalkyl-containing 3-hydroxyimino-1,5-benzodiazepin-2-ones and 2-hydroxy-3-hydroxyimino-2-trifluoromethyl-4-phenyl-1H-1,5-benzodiazepine possess high tuberculostatic activity comparable with that of isoniazide. Tests for acute toxicity of the trifluoromethylated heterocycles showed that they are less toxic than isoniazide

\\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2011, 45 (2), 75.pdf
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8.
Инвентарный номер: нет.
   
   S 98

   
    Synthesis, toxicity, and antituberculosis activity of isoniazid derivatives containing sterically hindered phen [Electronic resource] / Yu. N. Oludina, A. D. Voloshina, M. V. Kulik, S. N. Skornyakov, G. L. Rusinov // Pharmaceutical Chemistry Journal. - 2014. - Vol. 48, №1. - С. 5-7. - Bibliogr. : p. 7 (12 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
TOXICITY -- SYNTHESIS -- ISONIAZID DERIVATIVES
Аннотация: The toxicity and tuberculostatic activity of new isoniazid derivatives containing sterically hindered phenols were investigated. The investigated isoniazid derivatives exhibited lower activity and toxicity than isoniazid

\\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2014, 48 (1), 5-7.pdf
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9.
Инвентарный номер: нет.
   
   T 21

    Tarakhtii, E. A.
    The ability of new diaminoalkanes and their additive salts, effective in the mouse survival test, to protect the blood system in the bone marrow form of acute radiation disease / E. A. Tarakhtii, R. I. Ishmetova // Biology bulletin. - 2021. - Vol. 48, № 3. - P340-350
ББК р
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: A complex of parameters of the blood system of BALB/c mice was studied using alkanes symmetrically and asymmetrically replaced with heterocyclic amines, which protected 85–100% of mice after total exposure to 137Cs γ-radiation at the minimum lethal dose. The ability of substances of different structures to protect hematopoietic tissue in in vivo and in vitro experiments has been established. Differences in the rates of post-radiation repopulation of blood cells in protected mice were revealed, which are associated with the survival of the organism. It was found that the response to the effect of the investigated substances at the level of the organism (acute toxicity, anti-radiation activity, oxygen consumption by the body) and hematopoietic tissue (changes in cellularity in the hematopoietic organs and peripheral blood) depends on the structure of the substance (length of the aliphatic chain, acidic component).

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10.
Инвентарный номер: нет.
   

    Tchaikovskaya, O.
    Kinetic model for UV/H2O2 degradation of 8-methoxypsoralen / O. Tchaikovskaya, N. Bryantseva, V. Krayukhina // Proceedings of SPIE - The International Society for Optical Engineering 13. Сер. "International Conference on Atomic and Molecular Pulsed Lasers XIII" . - Tomsk, 2018. - P1061422
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
8-METHOXYPSORALEN -- FUROCOUMARIN -- H2O2 -- IRRADIATING -- KRCL AND XEBR EXCILAMPS -- PHOTO-INDUCED DEGRADATION -- PUVA THERAPY
Аннотация: The influence of Crossed D sign?2Crossed D signz2 on the degradation of 8-methoxypsoralen (8-MOP) in water-ethanol solutions under the action of KrCl and XeBr excilamp radiation in a photoreactor is investigated. A kinematic model of photodegradation of the investigated molecule is constructed. In water-ethanol solutions the addition of Crossed D sign?2Crossed D signz2 altered the mechanism of decay of 8-MOP under the action of a KrCl excilamp in comparison with irradiation by a XeBr excilamp. This behavior is explained by the fact that the action of 283 nm radiation leads to accumulation of a stable photoproduct. In order to establish the toxicity of this product further research is needed.

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