Центральная Научная Библиотека УрО РАН

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   M 46

    Medvedeva, N.
    Study of rare encounters in a membrane using quenching of cascade reaction between triplet and photochrome probes with nitroxide radicals [Text] / N. Medvedeva, V. Papper, G. I. Likhtenshtein // Physical Chemistry Chemical Physics. - 2005. - Vol. 7, № 18. - P3368-3374. - Библиогр. : с. 3373 (26 назв.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: Measurements of active encounters between molecules in native membranes containing ingredients, including proteins, are of prime importance. To estimate rare encounters in a high range of rate constants (rate coefficients) and distances between interacting molecules in membranes, a cascade of photochemical reactions for molecules diffusing in multilamellar liposomes was investigated. The sensitised cascade triplet cis-trans photoisomerisation of the excited stilbene involves the use of a triplet sensitiser (Erythrosin B), a photochrome stilbene-derivative probe (4-dimethylamino-4 -aminostilbene) exhibiting the phenomenon of trans-cis photoisomerisation, and nitroxide radicals (5-doxyl stearic acid) to quench the excited triplet state of the sensitiser. Measurement of the phosphorescence lifetime of Erythrosin B and the fluorescence enhancement of the stilbene-derivative photochrome probe, at various concentrations of the nitroxide probe, made it possible to calculate the quenching rate constant kq= 1.1*10 15 cm2 M-1 s-1 and the rate constant of the triplet-triplet energy transfer between the sensitiser and stilbene probe kT= 1.0*1012 cm2 M-1 s-1. These values, together with the data on diffusion rate constant, obtained by methods utilising various theoretical characteristic times of about seven orders of magnitude and the experimental rate constants of about five orders of magnitude, were found to be in good agreement with the advanced theory of diffusion-controlled reactions in two dimensions. Because the characteristic time of the proposed cascade method is relatively large (0.1 s), it is possible to follow rare collisions between molecules and free radicals in model and biological membranes with a very sensitive fluorescence spectroscopy technique, using a relatively low concentration of probes.

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   H 86

    Hristov, P. K.
    Lipid peroxidation induced by ultrasonication in Ehrlich ascitic tumor cells [] / P. K. Hristov, L. A. Petrov, E. M. Russanov // Cancer Letters. - 1997. - Vol.121, N1. - С. 7-10

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The mechanism of sonodynamic action in tumor cells is poorly investigated. It is known that ultrasound generates free radicals in phosphatidylcholine liposomes used as a membrane model. The participation of lipid peroxidation products in the mechanisms of physiological suppression of cell multiplication has been investigated for some tumor cells

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   K 81

    Krasnov, V. P.
    Nano-sized melphalan and sarcolysine drug delivery systems: synthesis and prospects of application [Electronic resource] / V. P. Krasnov, M. A. Korolyova, E. L. Vodovozova // Russian Chemical Reviews. - 2013. - Vol.82, №8. - С. 783-814. - Bibliogr. : p. 811-814 (196 ref.)

ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
SARCOLYSINE -- SYNTHESIS -- NANO-SIZED
Аннотация: The results of experimental studies concerned with the development of nano-sized drug delivery systems for the antitumour drugs sarcolysine and melphalan are generalized. The structures and biological activities of nanocarriers in comparison with unmodified drugs are discussed. Particular attention is given to the liposomes containing lipid derivatives of sarcolysine and melphalan in the lipid bilayer

\\\\expert2\\NBO\\Russian Chemical Reviews\\2013, V.82, N8, p.783.pdf
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   L 79


    Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors / A. R. Tsygankova, D. A. Gruzdev, V. V. Kanygin [et al.] // Mendeleev Communications. - 2021. - Vol. 31, № 5. - P659-661

ББК Г
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
AMIDE -- CLOSO-CARBORANES -- LIPOSOMES -- U87 TUMOR MODEL -- TOXICITY -- BIODISTRIBUTION
Аннотация: Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.

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