H 99 Influence of the nature of the stationari phase on the retention of polyfluorinated carboxylates [Text] / E. P. Promyshlennikova, V. E. Kirichenko, K. I. Pashkevich, D. N. Grigoreva, R. V. Golovina // Journal of Analytical Chemistry. - 1992. - Vol. 47, N 6. - P781-785 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
B 57 Biginelli condensations of fluorinated 3-oxo esters and 1,3-diketones [Text] / V. I. Saloutin, Ya. V. Burgart, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin // Journal of Fluorine Chemistry. - 2000. - Vol. 103, № 3. - P17-23 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Condensation of fluorinated 3-oxo esters or 1,3-diketones with benzaldehyde and (thio)urea results in the diastereoselective formation of 4-fluoroalkyl-4-hydroxy-2-oxo(thioxo)-6-phenyl-hexahydropyrimidine-5-carboxylates from which by dehydration under acidic conditions the corresponding 6-fluoroalkyl-2-oxo(thioxo)-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates were obtained. Under the same conditions, hexafluoroacetylacetone furnishes 4,6-dihydroxy-4,6-di(trifluoromethyl)-hexahydropyrimidin-2-one. Some further reactions of these pyrimidine derivatives leading to fused heterocycles are described.???? |
N 52 New approach to [a]-fused fluoroquinolones: the synthesis of 5-oxo-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinolines [Electronic resource] / E. Tsoi, V. N. Charushin, E. V. Nosova, G. N. Lipunova, A. V. Tkachev // Mendeleev Communications. - 2001. - Vol. 11, № 2. - P53-54 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The reaction of N-(ethoxycarbonyl)methyl substituted ethyl 6,7-difluoro-, 6,7,8-trifluoro- and 5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylates with methyl methacrylate results in the [3 + 2] adducts, hexahydropyrrolo[1,2-a]quinolones, which can be precursors of [a]-fused fluoroquinolones.?????? \\\\expert2\\nbo\\Mendeleev Communications\\2001, v.11, N 2. p.53.pdf |
P 93 Prokhorov, A. M. CuCl2 induced reactions of 6-ethynyl- and 6-cyano-5-aryl-2,2-bipyridines with various N- and O-nucleophiles in comparison with the reactions of relative 1,2,4-triazines [Text] / A. M. Prokhorov, P. A. Slepukhin, D. N. Kozhevnikov // Journal of Organometallic Chemistry. - 2008. - Vol. 693, № 10. - P1886-1894 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Meanwhile 5-aryl-6-cyano-2,2-bipyridines are very stable towards various nucleophiles, addition copper(II) chloride to the reactional mixture facilitates nucleophilic addition to the cyano group dramatically. The cyanobipyridines react easily with water, methanol, ethanolamine in the presence of CuCl2 yielding well-crystallized complexes containing carboxylates, carboximidates or carboxamidines as ligands. 5-Cyano-1,2,4-triazines are more active in the reactions due to higher electron-withdrawing properties of this heterocycle. Due to the same reason acetylene moiety of 5-ethynyl-3-pyridyl-1,2,4-triazine adds water quite easily but in the presence of copper chloride as well \\\\Expert2\\nbo\\Journal of Organometallic Chemistry\\2008, v.693, p.1886.pdf |
S 73 Sosnovskikh, V. Ya. One-pot three-component reaction of 3-(polyfluoroacyl)chromones with active methylene compounds and ammonium acetate: regioselective synthesis of novel RF-containing nicotinic acid derivatives [Text] / V. Ya. Sosnovskikh, R. A. Irgashev, M. I. Kodess // Tetrahedron. - 2008. - Vol. 64, № 13. - P2997-3004 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): THREE-COMPONENT REACTIONS -- AMMONIUM ACETATE Аннотация: Reactions of 3-(polyfluoroacyl)chromones with acetoacetamide and ethyl acetoacetate in the presence of ammonium acetate proceed at the C-2 atom of the chromone system with pyrone ring-opening and subsequent cyclization to 5-salicyloyl-2-methyl-6-(trifluoromethyl)nicotinamides, ethyl 5-salicyloyl-2-methyl-6-(trifluoromethyl)nicotinates, and ethyl 5-hydroxy-2-methyl-5-(polyfluoroalkyl)-5H-chromeno[4,3-b]pyridine-3-carboxylates. Similar reaction with ?-aminocrotononitrile gave 5-hydroxy-2-methyl-5-(polyfluoroalkyl)-5H-chromeno[4,3-b]pyridine-3-carbonitriles???? \\\\Expert2\\nbo\\Tetrahedron\\2008, v. 64, N13, p. 2997.pdf |
F 71 Fokin, A. S. Fluorine-containing 3-arylhydrazono-2,4-dioxobutanoates in reactions with difunctional nucleophiles [Electronic resource] / A. S. Fokin, Ya. V. Burgart, V. I. Saloutin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2006. - Vol. 42, № 6. - P887-896 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 3-Arylhydrazono-4-polyfluoroalkyl-2,4-dioxobutanoates reacted with hydrazines to give ethyl 4-aryldiazeno-3-polyfluoroalkyl-1H-pyrazole-5-carboxylates, while analogous reactions of ethyl 3-arylhydrazono-4-pentafluorophenyl-2,4-dioxobutanoates resulted in the formation of 4-aryldiazeno-3-pentafluorophenyl-1,2-dihydropyridazine-5,6-diones or 6-aryl-7,8,9,10-tetrafluoro-2-phenyl-2,4a,6,10b-tetradropyridazo[4,3-c]cinnoline-3,4-diones, depending on the conditions. Cyclocondensation of ethyl 3-arylhydrazono-4-polyfluoroalkyl(or pentafluorophenyl)-2,4-dioxobutanoates with ethylenediamine led to 3-[1-arylhydrazono-2-oxo-2-polyfluoroalkyl(or pentafluorophenyl)ethyl]-5,6-dihydropyrazin-2(1H)-ones, and 3-[1-arylhydrazono-2-oxo-2-polyfluoroalkyl(pentafluorophenyl)ethyl]benzoxazin-2-ones were formed in the condensation with o-aminophenol. Pentafluorophenyl-substituted heterocycles were found to undergo intramolecular ring closure to give 3-hetaryl-substituted 1-aryl-5,6,7,8-tetrafluoro-1,4-dihydrocinnolin-4-ones. The reactions of ethyl 3-arylhydrazono-4-pentafluorophenyl-2,4-dioxobutanoates with o-aminobenzenethiol gave 3-[7-(2-aminophenylsulfanyl)-1-aryl-5,6,8-trifluoro-4-oxo-1,4-dihydrocinnolin-3-yl]benzothiazin-2-ones; 8a-hydroxy-11,12,13,14-tetrafluoro-10-(4-methoxyphenyl)-2,3,4,5,6,7,8a,10-octahydropyrazino[1?,2?:4,5][1,4]diazepino[6,7-c]cinnolin-8-one was isolated in the condensation of ethyl 3-(4-methoxyphenylhydrazono)-4-pentafluorophenyl-2,4-dioxobutanoate with N-(2-aminoethyl)ethane-1,2-diamine ?? \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2006, 42 (6), 887.pdf |
S 98 Synthesis of derivatives of pyrazolo[1,5- a ]pyrimidines and imidazo[1,5- a ]pyrimidines proceeding from alkyl 2-benzylidene-3-oxo-3-fluoroalkylpropionates [Electronic resource] / M. V. Pryadeina, Ya. V. Burgart, V. I. Saloutin, P. A. Slepukhin, E. V. Sadchikova, E. N. Ulomskii // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2009. - Vol. 45, № 2. - P242-247 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Methods were developed of the synthesis of alkyl 2-hydroxy-2-fluoroalkyl-4-phenyl-1,2,3,4—tetrahydroimidazo-[1,5-a]pyrimidine-3-carboxylates and alkyl-5-hydroxy-2,7-diphenyl-5-fluoroalkyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-6-carboxylates by regioselective [3+3]-cycloaddition of 5-aminoimidazole or 5-aminopyrazole to alkyl 2-benzylidene-3-oxo-3-fluoroalkylpropionates at the fluoroacylvinyl fragment \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2009, 45 (2), 242.pdf |
R 35 Regioselective cyclocondensation of ethyl 2-ethoxymethylidene-3-oxo-3-polyfluoroalkylpropionates with thiazolylhydrazines [Electronic resource] / M. V. Pryadeina, A. V. Denisova, Ya. V. Burgart, V. I. Saloutin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2008. - Vol. 44, № 12. - P1811-1815 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Ethyl 2-ethoxymethylidene-3-oxo-3-polyfluoroalkylpropionates reacted in a regioselective fashion with thiazolylhydrazines to give the corresponding ethyl 1-thiazolyl-5-fluoroalkyl-1H-pyrazole-4-carboxylates. The product structure was determined on the basis of NMR and X-ray diffraction data \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2008, 44 (12), 1811.pdf |
3-Methylidene-2,4-dioxo-4-pentafluorophenylbutanoates in the Synthesis of Heterocycles [Electronic resource] / A. S. Fokin, Ya. V. Burgart, V. I. Saloutin, O. N. Chupakhin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2005. - Vol. 41, № 9. - P1354-1358 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: 3-Ethoxy- and 3-arylaminomethylidene-2,4-dioxo-4-pentafluorophenylbutanoates undergo cyclization by the action of hydrazine hydrate and phenylhydrazine to give ethyl 4-pentafluorobenzoylpyrazole-5-carboxylates. The reaction of 3-ethoxymethylidene-2,4-dioxo-4-pentafluorophenylbutanoate with o-phenylene-diamine leads to formation of 3-[2-(2-aminophenylamino)-1-pentafluorobenzoylethenyl]-1,2-dihydroquinoxa-lin-2-one. 3-Arylaminomethylidene-2,4-dioxo-4-pentafluorophenylbutanoates react with o-phenylenediamine to afford 3-(1-aryl-5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinolin-3-yl)-1,2-dihydroquinoxalin-2-ones and/or 3-(2-arylamino-1-pentafluorobenzoylethenyl)-1,2-dihydroquinoxalin-2-ones \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2005, 41 (9), 1374-1376.pdf |
S 98 Synthesis of substituted pyrido[1,2-a]pyrimidines from 2-arylmethylidene-3-fluoroalkyl-3-oxopropionates [Electronic resource] / M. V. Pryadeina, Ya. V. Burgart, M. I. Kodess, V. I. Saloutin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2005. - Vol. 54, № 12. - P2841-2845 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): CYCLOCONDENSATION -- REGIOISOMERISM -- 2-ARYLMETHYLIDENE Аннотация: Cyclocondensation of 2-arylmethylidene-3-fluoroalkyl-oxopropionates with 2-amino-pyridine occurs at both the polyfluoroacylvinyl and alkoxycarbonylvinyl fragments to give alkyl 4-aryl-2-polyfluoroalkyl-4H-pyrido[1,2-a]pyrimidine-3-carboxylates and 4-aryl-2-hydroxy-3-polyfluoroacyl-4H-pyrido[1,2-a]pyrimidines, respectively. When treated with copper(II) acetate, the pyrido[1,2-a]pyrimidines yield metal complexes \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2005, 54 (12), 2841-2845.pdf |
R 59 Ring-chain isomerism of ethyl 7-polyfluoroalkyl-7-hydroxy-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylates [] / M. V. Pryadeina, Ya. V. Burgart, V. I. Saloutin, O. N. Chupakhin // Mendeleev Communications. - 2008. - Vol. 18, № 5. - С. 276-277. - Bibliogr. : p.277 (10 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Cyclisation of ethyl 2-ethoxymethylidene-3-oxo-3-polyfluoroalkylpropionates with 3-amino-1H-[1,2,4]triazole gives ethyl 7-polyfluoroalkyl-7-hydroxy-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylates that are subject to ring–chain isomerisation in solution, depending on the solvent and the length of the polyfluoroalkyl substituent, to yield ethyl 3-polyfluoroalkyl-3-oxo-2-{([1,2,4]triazol-3-yl)aminomethylidene}propionates via heterocyclic ring opening at the C(7)–N(8) bond \\\\Expert2\\nbo\\Mendeleev Communications\\2008, v.18, p.276.pdf |
A 37 Alkyl 3-fluoroalkyl-3-oxopropionates in reactions with azolyldiazonium salts [Electronic resource] / E. V. Shchegol'kov, E. V. Sadchikova, Ya. V. Burgart, V. I. Saloutin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2008. - Vol. 57, № 3. - P612-618 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Alkyl 3-fluoroalkyl-3-oxopropionates react with antipyrinyldiazonium chloride to form 2-antipyrinylhydrazono-3-fluoroalkyl-3-oxopropionates. The use in these reactions of hetaryldiazonium salts, containing NH group in the ? position, leads to alkyl 7-fluoroalkyl-7-hydroxy-4,7- dihydroazolo[5,1-c]triazine-6-carboxylates. 3-Amino-1H-1,2,4-triazole, 3-amino-4-ethoxycar- bonyl-1H-pyrazole, and 5-amino-4-ethoxycarbonyl-1H-imidazole were used as the heterocyclic component \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2008, 57 (3), 612.pdf |
S 98 Synthesis of fluorine-containing alkyl 2-cyano-3-oxocarboxylates. Reactions with nucleophiles [Electronic resource] / O. G. Kuzueva, Ya. V. Burgart, V. I. Saloutin, O. N. Chupakhin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 1999. - Vol. 48, № 10. - P1937-1941 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorine-containing alkyl 2-cyano-3-oxocarboxylates were synthesized for the first time by the reaction of ethyl cyanoacetate with fluorine-substituted carboxylic acid halides or alkyl carboxylates. The reactions with hydrazine hydrate, phenylhydrazine, ando-phenylenediamine give hydrazinium (ammonium) enolates or products of acid decomposition \\\\Expert2\\nbo\\Russian Chemical Bulletin\\1999, 48 (10), 1937.pdf |
S 98 Synthesis and Structure of Isopropyl 5-Methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrymidine-6-carboxylates [Text] / I. N. Vladimirov, A. A. Zorina, E. V. Nosova, V. L. Gein, O. V. Fedorova, M. I. Vakhrin // IV International Conference "Multi-Component Reactions and Related Chemistry", Ekaterinburg, 24-28 May 2009. - Екатеринбург, 2009. - PS 49 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
S 72 Sonochemical synthesis of Biginelli compounds [Electronic resource] / M. S. Zhidovinova, O. V. Fedorova, G. L. Rusinov, I. G. Ovchinnikova // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2003. - Vol. 52, № 11. - P2527-2528 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The ultrasound effect accelerates the Biginelli reaction 40 and more times. A sonochemical method for the synthesis of ethyl 4-R-6-methyl-2-oxo- and 4-R-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates was developed. The target products were obtained within 2 to 5 min in 90—95% yields. \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2003, 52 (11), 2527.pdf |
R 30 Reactions of zinc enolates derived from 1-aryl-2-bromo-2-phenylethanone and 2-bromoindan-1-one with alkyl 2-oxochromene-and 6-bromo-2-oxochromene-3-carboxylates [Electronic resource] / V. V. Shchepin, A. E. Korzun, M. I. Vakhrin, P. S. Silaichev, M. A. Ezhikova, M. I. Kodess // Russian Journal of General Chemistry. - 2006. - Vol. 76, № 5. - P777-780 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Zinc enolates derived from 1-aryl-2-bromo-2-phenylethanone react with alkyl 2-oxochromene-3-carboxylates and methyl 6-bromo-2-oxochromene-3-carboxylate to give, respectively, alkyl 4-(2-aryl-2-oxo-1-phenylethyl)-2-oxochroman-3-carboxylates and methyl 6-bromo-4-(2-aryl-2-oxo-1-phenylethyl)-2-oxochroman-3-carboxylate as a single stereoisomer. Zinc enolates derived from 2-bromoindan-1-one react with alkyl 2-oxochromene-3-carboxylates to give alkyl 2-oxo-4-(1-oxoindan-2-yl)chroman-3-carboxylates as a single stereoisomer \\\\Expert2\\nbo\\Russian Journal of General Chemistry\\2006, V. 76, N 5, p.777.pdf |
C 98 Cyclopropanation of 2-arylmethylidenemalononitriles, alkyl 3-aryl-2-cyanoprop-2-enoates, and N-substituted 3-aryl-2-cyanoprop-2-enamides with bromine-containing zinc enolates [Electronic resource] / V. V. Shchepin, Yu. G. Stepanyan, P. S. Silaichev, M. A. Ezhikova, M. I. Kodess // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2007. - Vol. 43, № 7. - P1002-1007 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Zinc enolates derived from 2,2-dibromoindan-1-one and 2,2-dibromo-1,2,3,4-tetrahydronaphthalen-1-one reacted with 2-arylmethylidenemalononitriles, alkyl 3-aryl-2-cyanoprop-2-enoates, and N-substituted 3-aryl-2-cyanoprop-2-enamides to give, respectively, 3-aryl-1?-oxo-1?,3?-dihydrospiro[cyclopropane-1,2?-indene]-2-2-dicarbonitriles, 3-aryl-1?-oxo-3?,4?-dihydro-1?H-spiro[cyclopropane-1,2?-naphthalene]-2,2-dicarbonitriles, alkyl 3-aryl-2-cyano-1?-oxo-1?,3?-dihydrospiro[cyclopropane-1,2?-indene]-2-carboxylates, alkyl 3-aryl-2-cyano-1?-oxo-3?,4?-dihydro-1?H-spiro[cyclopropane-1,2?-naphthalene]-2-carboxylates, and N-substituted 3-aryl-2-cyanol-1?-oxo-3?,4?-dihydro-1?H-spiro[cyclopropane-1,2?-naphthalene]-2-carboxamides as a single diastereoisomer. The stereoconfiguration of the products was determined by 1H and 13C NMR spectroscopy \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2007, 43 (7), 1002.pdf |
R 30 Reaction of alkyl 5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylates with zinc enolates prepared from zinc and 1-arul-2-bromo-2-phenylethanones, 2 bromoindanone, and 2-bromo-6-methyltetralone [Electronic resource] / V. V. Shchepin, A. E. Korzun, M. I. Vakhrin, P. S. Silaichev, M. A. Ezhikova, M. I. Kodess // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2006. - Vol. 42, № 8. - P1169-1173 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Alkyl 5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylates react with zinc enolates prepared from 1-aryl-2-bromo-2-phenylethanones, 2-bromo indanone, 2-bromo-6-methyltetralone and zinc with formation of ethyl 4-(2-aryl-2-oxo-1-phenyl-ethyl)-5,5-dimethyl-2-oxotetrahydrofuran-3-carboxylates, alkyl 5,5-dimethyl-2-oxo-4-(1-oxoindan-2-yl)tetrahydrofuran-3-carboxylates, and ethyl 5,5-dimethyl-4-(6-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-2-oxotetrahydrofuran-3-carboxylates respectively, mainly as single diastereomers \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2006, 42 (8), 1169.pdf |
C 98 Cyclopropanation of N-substituted 3-aryl-2-cyanoprop-2-enamides and derivatives of 5,5-Dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylic acid and 2-oxochromene-3-carboxylic acid with bromine-containing zinc enolates [Electronic resource] / V. V. Shchepin, P. S. Silaichev, Yu. G. Stepanyan, M. M. Kalyuzhnyi, N. Yu. Russkikh, M. I. Kodess // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2006. - Vol. 42, № 7. - P973-980 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Zinc enolates derived from 1-aryl-2,2-dibromoalkanones react with N-substituted 3-aryl-2-cyanoprop-2-enamides and 5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylic and 2-oxochromene-3-carboxylic acid derivatives to give, respectively, N-substituted 2-alkyl-3-aryl-2-aroyl-1-cyanocyclopropane-1-carboxamides, 6-(4-bromobenzoyl)-4,4,6-trimethyl-2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester and morpholide, and 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropla[c]chromene-1a-carboxylic acids as a single geometric isomer. Treatment of 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropa[c]chromene-1a-carboxylic acids with carboxylic acid anhydrides leads to the formation of the corresponding 9c-alkyl-1-aryl-3,4-dioxo-9b,9c-dihydro-2,5-dioxacyclopenta[2,3]cyclopropa[1,2-a]naphthalen-1-yl carboxylates \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2006, 42 (7), 973.pdf |
S 98 Synthesis of fluorine-containing quinoline-2,3-dicarboxylates from products of vicarious nucleophilic substitution of hydrogen in 3-fluoronitroarenes [Electronic resource] / S. K. Kotovskaya, G. A. Zhumabaeva, V. N. Charushin, O. N. Chupakhin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2009. - Vol. 58, № 1. - P170-175 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The reactions of 3-fluoro-4-R-6-phenylsulfonylmethylnitrobenzenes with dimethyl fumarate or diethyl maleate in acetonitrile in the presence of an excess of K2CO3 and a catalytic amount of 18-crown-6 afforded mixtures of dialkyl 6-R-7-fluoro- and dialkyl 6-R-7-phenylsulfonylquinoline-2,3-carboxylate N-oxides, as well as dialkyl 6-R-7-fiuoro- quinoline-2,3-carboxylates (alkyl is methyl or ethyl), which were resolved by column chromatography and identified by 1H NMR spectroscopy and X-ray diffraction \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2009, 58 (1), 170-175.pdf |