S 98 Synthesis and antiviral activity of 2-amino-3-ethoxycarbonylpyrazine derivatives [Electronic resource] / V. L. Rusinov [et al.] // Pharmaceutical Chemistry Journal. - 2005. - Vol. 39, № 12. - P630-635. - Библиогр. : с. 635 (6 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A series of substituted 2-amino-3-ethoxycarbonylpyrazines containing indole, resorcinol, thiophenol, ethyl cyanoacetate, indandione, and antipyrine moieties was obtained via reactions of nucleophilic substitution of hydrogen in the initial 2-aminopyrazine-1-oxides. Some of the synthesized compounds inhibit the reproduction of measles viruses and exhibit a weak antiviral activity with respect to Marburg virus. However, most of the new substituted pyrazines are not cytotoxic and exhibit no activity against ortho-poxviruses and measles viruses. \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2005, 39 (12), 630.pdf |
N 52 New opportunities for the synthesis of quinoxaline-substituted heterocyclic and aryl moieties [Electronic resource] / Y. A. Azev, M. I. Kodess, M. A. Ezhikova, A. M. Gibor, V. I. Baranov, O. S. Ermakova, V. A. Bakulev // Pharmaceutical Chemistry Journal. - 2013. - Vol.47, №9. - С. 498-502. - Bibliogr. : p. 502 (10 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): DIMEDONE -- INDANDIONE -- DMSO SOLUTION Аннотация: 6.7-Difluoroquinoxaline (I) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa - c. Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId. 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV. Heating products IIa - c with N-methylpiperazine produced 7-methylpiperazine derivatives Va - c of 2-substituted quinoxalines \\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2013, 47 (9), 498.pdf |