P 51 Petrological model of formation of giant ore deposits [Text] / A. A. Marakushev, N. A. Paneyakh, V. L. Rusinov, N. N. Pertsev, I. A. Zotov // Geology of Ore Deposits. - 1998. - Vol. 40, № 3. - P211-227. - Bibliogr. : p. 227 (46 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): PETROLOGICAL MODEL -- MODELLING -- ORE -- ORE DEPOSITS Аннотация: The available data on the giant ore deposits of chromium (Kempirsai in the Urals), platinum-group metals (Bushveld in Africa), platinum-bearing copper-nickel ores (Talnakh in the Noril'sk district, northern part of the Siberian Platform), zinc-copper (massive sulfide) ores (Gai, Sibai, and Uchaly) and apatite deposits (Khibiny, the Kola Peninsula) is summarized. The giant sizes of the deposits are caused by extraordinary ore-forming processes directly associated with the highly extensive petrogenetic processes. These processes resulted in the formation of peculiar dunites in the hyperbasite complexes (chromite ores), agpaitic urtites in alkaline associations (apatite deposits), development of low-sulfide horizons and hortonolite dunites in the basite-hyperbasite layered intrusions (platinum-group metal deposits), specific processes of transmagmatic sulfurization of the iron-rich igneous differentiates (Cu-Ni sulfide and massif sulfide ores), and processes of magmatic replacement of hyperbasites that cause the alkaline agpaitic affinity of magmatism. This agpaitic tendency increases the solubility of carbon-bearing fluid components (CO2, CH4, etc.) in magma and leads to the concentration of ore metals, which form chloride-carbonate and hydrocarbon migrating compounds in the transmagmatic fluids. Some mineralogical-petrological prospecting criteria are deduced on the basis of genetic models of giant ore deposits. |
I-60 Influence of a biologically active compound from substituted thiadiazines on transaminase activity in myocardial homogenate in experimental myocardial infarction [Electronic resource] / O. N. Chupakhin, A. Sarapultsev, M. Chereshneva, I. Gette, L. P. Sidorova, I. Danilova, P. Sarapultsev // International Journal of Pharmacy and Pharmaceutical Sciences. - 2015. - Vol. 7, № 6. - С. 147-151. - Bibliogr. : p. 151 (21 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): ENZYMES -- MYOCARDIAL INFARCTION -- L-17 COMPOUND Аннотация: Objective: Earlier works have reported on the effectiveness of the compounds of the group of substituted 5R1, 6R2, 3,4-thiadiasine-2-amines for treating experimental myocardial infarction, conditioned by the immune-modifying action of the compound. The purpose of this study was to evaluate the action of the L17 compound of the group of substituted 5R1, 6R2, 3,4-thiadiasine-2-amines on the extent of injury and the possible recurrence of experimental myocardial infarction by the dynamic assessment of transaminase activity in blood and myocardial homogenate (tissue). Methods: Modelling of myocardial infarction in rats was performed in accordance with the author’s modification of the standard ligation model. Tissue enzyme activity of LDH and CK-MB was evaluated at days 1, 7, and 14. Results: According to the results, the decrease in LDH 1-2 activity in tissue (after experimental myocardial infarction) corresponded to the increase in enzyme activity in blood on the first day of the experiment. However, on the seventh day of the experiment, the decrease of LDH 1-2 activities in the tissue of animals treated with L17 compound corresponded with the decrease of LDH activity in blood, while in non-treated animals the relation between the enzyme levels in blood and tissue was typical for the onset of MI. Conclusions: The evaluation of enzyme levels in myocardial tissue confirms previouslyreported data that the administration of a thiadiazine compounds prevents the recurrence and decreases the size of experimental myocardial infarction. \\\\expert2\\nbo\\International Journal of Pharmacy and Pharmaceutical Sciences\\52015. V. 7, N 6. P. 147-151.pdf |
Acylative kinetic resolution of racemic methyl-substituted cyclic alkylamines with 2,5-dioxopyrrolidin-1-yl (R)-2-phenoxypropanoate / D. A. Gruzdev, S. A. Vakarov, M. A. Korolyova [et al.] // Organic & biomolecular chemistry. - 2022. - Vol. 20, № 4. - P862-869 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The diastereoselective acylation of a number of racemic methyl-substituted cyclic alkylamines with active esters of 2-phenoxypropanoic acid was studied in detail. The ester of (R)-2-phenoxypropanoic acid and N-hydroxysuccinimide was found to be the most selective agent. The highest stereoselectivity was observed in the kinetic resolution of racemic 2-methylpiperidine in toluene at −40 °C (selectivity factor s = 73) with the predominant formation of (R,R)-amide (93.7% de). To explain the observed stereoselectivity, DFT modelling of the transition states in the reactions of the title acylating agent with 2-methylpiperidine and 2-methylpyrrolidine was performed. The calculated values were in good agreement with experimental data. It has been demonstrated that the acylation proceeds via a concerted mechanism, in which the addition of an amine occurs simultaneously with the elimination of the hydroxysuccinimide fragment. The high stereoselectivity of the (R,R)-amide formation is largely ensured by the lower steric hindrances in the transition states as compared to the formation of (R,S)-amide. |