R 30 Reactions of quinoxaline with 3-methyl-1-phenylpyrazol-5-one / Y. A. Azev, E. D. Oparinaa, I. S. Kovalev, P. A. Slepukhin, R. K. Novikova // Mendeleev Communications. - 2012. - Vol.22, №1. - С. 37-38 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): QUINOXALINES -- PHENYLPYRAZOL -- TRIETHYLAMINE Аннотация: Quinoxaline during the reaction with 3-methyl-1-phenylpyrazol-5-one in the presence of triethylamine at room temperature in dimethylsulfoxide eliminates o-phenylenediamine and gives 4,4’-methylene-bis(3-methyl-1-phenylpyrazol-5-one) and 1,1,2,2-tetrakis(5-methyl-2-oxo-2-phenyl-1,2-dihydro-3H-pyrazol-4-yl)ethane. The latter was proved to be the intermediate to form the above dipyrazolylmethane derivative \\\\Expert2\\nbo\\Mendeleev Communications\\2012, v.22, p. 37.pdf |
N 52 New opportunities for the synthesis of quinoxaline-substituted heterocyclic and aryl moieties [Electronic resource] / Y. A. Azev, M. I. Kodess, M. A. Ezhikova, A. M. Gibor, V. I. Baranov, O. S. Ermakova, V. A. Bakulev // Pharmaceutical Chemistry Journal. - 2013. - Vol.47, №9. - С. 498-502. - Bibliogr. : p. 502 (10 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): DIMEDONE -- INDANDIONE -- DMSO SOLUTION Аннотация: 6.7-Difluoroquinoxaline (I) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa - c. Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId. 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV. Heating products IIa - c with N-methylpiperazine produced 7-methylpiperazine derivatives Va - c of 2-substituted quinoxalines \\\\expert2\\nbo\\Pharmaceutical Chemistry Journal\\2013, 47 (9), 498.pdf |