L 62 Levit, G. L. Synthesis of Amides of Nonsteroidal Anti-Inflammatory Drugs with Potentially Low Gastrotoxicity [Text] : доклад, тезисы доклада / G. L. Levit, M. A. Koroleva, V. P. Krasnov // International Memorial I.Postovsky Conference on Organic Chemisty, Ekaterinburg, March 17-20, 1998 : program and abstracts. - Ekaterinburg, 1998. - P91 Рубрики: ХИМИЧЕСКИЕ НАУКИ ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ |
L 62 Levit, G. L. Syntesis of N-alkylnitrosocarbomoil derivatives of alfa,omega-diamino acid posessing anticancer activity [Text] / G. L. Levit, L. B. Radina, N. M. Peretolchina // Amino Acids. - 1995. - Vol. 7, N 1 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
K 46 Kinetic resolution of (+/-)-2,3-dihydro-3-methyl-4H-1,4-benzoxazines with (S)-naproxen [Text] / V. N. Charushin, V. P. Krasnov, G. L. Levit, M. A. Koroleva, M. I. Kodess, O. N. Chupakhin, M. N. Kim, H. S. Lee, Y. J. Park, K. -C. Kim // Tetrahedron: Asymmetry . - 1999. - Vol. 10, N 14. - P2691-2702 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
A 18 Acidic hydrolysis of N-acyl-1-substituted 3-amino-1,2-dicarba-closo-dodecaboranes [Electronic resource] / G. L. Levit, A. M. Demin, M. I. Kodess, M. A. Ezhikova, L. Sh. Sadretdinova, V. A. Ol'shevskaya, V. N. Kalinin, V. P. Krasnov, V. N. Charushin // Journal of Organometallic Chemistry. - 2005. - Vol. 690, № 11. - P2783-2786 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Acidic hydrolysis of N-acyl 1-methyl- and 1-phenyl-3-amino-1,2-dicarba-closo-dodecaboranes has been studied. It has been shown that acidic hydrolysis of diastereomeric amides of 1-methyl-3-amino-1,2-dicarba-closo-dodecaborane results in the partial racemization of the target 3-amino-1-methylcarborane. Under the similar conditions, the hydrolysis of N-acyl-3-amino-1-phenyl-1,2-dicarba-closo-dodecaboranes resulted in amide bond cleavage accompanied by simultaneous deboronation with the removal of boron atom at position 6 of carborane cage and formation of 7,8-dicarba-nido-undecaborane derivative according to 11B and 1H NMR spectroscopy. \\\\Expert2\\nbo\\Journal of Organometallic Chemistry\\2005, v. 690, p.2783.pdf |
N 72 NMR determination of enantiomeric composition of 1-substituted 3-amino-1,2-dicarba-closo-dodecaboranes using Eu(hfc)3 [Electronic resource] / M. I. Kodess, M. A. Ezhikova, G. L. Levit, V. P. Krasnov, V. N. Charushin // Journal of Organometallic Chemistry. - 2005. - Vol. 690, № 11. - P2766-2768 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Experimental conditions for determination of enantiomeric composition of 1-substituted 3-aminocarboranes by 1H and 13C NMR spectroscopy using chiral shift reagent Eu(hfc)3 have been found. \\\\Expert2\\nbo\\Journal of Organometallic Chemistry\\2005, v. 690, p.2766.pdf |
K 46 Kinetic resolution of 1-methyl- and 1-phenyl-3-amino-1,2-dicarba-closo-dodecaboranes via acylation with chiral acyl chlorides [Electronic resource] / G. L. Levit, V. P. Krasnov, A. M. Demin, M. I. Kodess, L. Sh. Sadretdinova, T. V. Matveeva, V. A. Ol'shevskaya, V. N. Kalinin, O. N. Chupakhin, V. N. Charushin // Mendeleev Communications. - 2004. - Vol. 14, № 6. - P293-295 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A study of the kinetic resolution of racemic 1-substituted 3-amino-1,2-dicarba-closo-dodecaboranes by chiral acyl chlorides has shown that N-tosyl-(S)-prolyl and N-phthaloyl-(S)-alaninyl chlorides are more efficient resolving agents than (S)-naproxen chloride. \\\\Expert2\\nbo\\Mendeleev Communications\\2004, v.14, p.293.pdf |
S 89 Structure and properties of 4-amino derivatives of 5-oxoproline [Text] / V. P. Krasnov, I. A. Nizova, A. Yu. Vigorov, T. V. Matveeva, G. L. Levit, P. A. Slepukhin, M. A. Ezhikova, M. I. Kodess // European Journal of Organic Chemistry. - 2008. - № 10. - P1802-1810 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: On the basis of the results obtained from NMR spectroscopy, X-ray analysis and chemical transformations, it was established that acidic hydrolysis of (2S,4S)-4-arylaminoglutamates results in the formation of lactams in which ring closure occurs with the participation of the Y-amino and alfa-COOH groups; but isomeric lactams resulting from the participation of the alfa-amino and Y-COOH groups are not formed. Isomeric lactams, that is, (2S,4S)-4-arylamino-5-oxoprolines, can be easily converted in acidic medium into more stable 4-amino-1-aryl-5-oxoprolines. |
S 98 Synthesis and Antileukemic Activity of N-Phthaloyl-2-amino alcohols [Electronic resource] / A. V. Osintsev, G. L. Levit, V. P. Krasnov, G. D. Miles, S. Yu. Solodnikov, E. A. Gun // Pharmaceutical Chemistry Journal. - 2004. - Vol. 38, № 3. - P120-122 Рубрики: ХИМИЧЕСКИЕ НАУКИ \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2004, 38 (3), 120.pdf |
N 10 N-Phthaloyl-(S)-alanyl chloride as a chiral resolving agent for the kinetic resolution of heterocyclic amines [Text] / V. P. Krasnov, G. L. Levit, M. I. Kodess, V. N. Charushin, O. N. Chupakhin // Tetrahedron: Asymmetry . - 2004. - Vol. 15, № 5. - P859-862 : ил. - Библиогр.: с. 862 (7 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): HETEROCYCLIC AMINES -- CHLORIDE -- KINETIC RESOLUTION Аннотация: Acylation of heterocyclic amines with N-phthaloyl-(S)-alanyl chloride under kinetic resolution conditions resulted in the predominant formation of (S,S)-amides. The diastereoselectivity of resolution depended heavily on the structure of the resolved amine.???? \\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2004, v.15, p.859.pdf |
D 62 Direct diastereoselective addition of l-menthol to activated 1,2,4-triazin-5(4H)-one [Text] / O. N. Chupakhin, G. V. Zyryanov, V. L. Rusinov, V. P. Krasnov, G. L. Levit, M. A. Koroleva, M. I. Kodess // Tetrahedron Letters. - 2001. - Vol. 42, № 12. - P2393-2395 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: For the first time in a triazine series it has been found that addition of a chiral O-nucleophile, l-menthol, to the C6-unsubstituted atom of 3-phenyl-1,2,4-triazin-5(4H)-one 1 activated by aliphatic acid anhydrides proceeds diastereoselectively to form a mixture of 1-acyl-6-[(1?R,3?R,4?S)-menthyl-3?)]-3-phenyl-(6S)-1,6-dihydro-1,2,4-triazin-5(4H)-ones 2 and 1-acyl-6-[(1?R,3?R,4?S)-menthyl-3?)]-3-phenyl-(6R)-1,6-dihydro-1,2,4-triazin-5(4H)-ones 3 in which the diastereomers 2 predominate. The diastereoselectivity of the process improves as the size of the N1-acyl substituent increases???? |
E 54 Enantiomers of 3-amino-1-methyl-1,2-dicarba-closo-dodecaborane [Text] / V. P. Krasnov, G. L. Levit, V. N. Charushin, M. I. Kodess, V. N. Kalinin, O. N. Chupakhin // Tetrahedron: Asymmetry . - 2002. - Vol. 13, № 16. - P1833-1835. - Bibliogr. : p. 1835 (6 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The enantiomers of 3-amino-1-methyl-1,2-dicarba-closo-dodecaborane were prepared by means of resolution of the racemic mixture via acylation by (S)-naproxen chloride followed by separation and subsequent acid hydrolysis of each of the diastereoisomeric amides. Partial racemization of enantiomeric 3-aminocarboranes was observed during acid hydrolysis \\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2002, v.13, p.1833.pdf |
E 27 Efficient large (ca. 40 g) laboratory scale preparation of (S)- and (R)-valine tert-butyl esters [Text] / V. P. Krasnov, G. L. Levit, I. M. Bukrina, A. M. Demin, O. N. Chupakhin, Ji Uk Yoo // Tetrahedron: Asymmetry . - 2002. - Vol. 13, № 17. - P1911-1914 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A large laboratory scale (ca. 40 g) method for the preparation of enantiomerically pure (S)- and (R)-valine tert-butyl esters has been developed. The method involves three steps: preparation of N-TFA-valines, preparation of valine tert-butyl esters using 2-methylpropene in dioxane in the presence of sulfuric acid, and isolation of the target compounds as the acetate derivative. The overall yield is up to 70% relative to the starting valine, ee being more than 98% (by HPLC)???? |
K 46 Kinetic resolution of (±)-2-methyl-1,2,3,4-tetrahydroquinoline and (±)-2-methylindoline [Electronic resource] / V. P. Krasnov, G. L. Levit, I. N. Andreeva, A. N. Grishakov, V. N. Charushin, O. N. Chupakhin // Mendeleev Communications. - 2002. - Vol. 12, № 1. - P27-28 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The acylation of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2-methylindoline by (S)-naproxen acyl chloride resulted in their kinetic resolution with the predominant formation of (S,S)-diastereoisomeric amides (de 78–76%), recrystallisation of which followed by acid hydrolysis gave individual (S)-isomers of heterocyclic amines???? \\\\expert2\\nbo\\Mendeleev Communications\\2002, v.12, N 1. p.27.pdf |
K 46 Kinetic resolution of (±)-2,3-dihydro-3-methyl-4H-1,4-benzoxazine in the reaction with (S)-naproxen chloride: A theoretical study [Electronic resource] / V. A. Potemkin, V. P. Krasnov, G. L. Levit, E. V. Bartashevich, I. N. Andreeva, M. B. Kuzminsky , N. A. Anikin, V. N. Charushin, O. N. Chupakhin // Mendeleev Communications. - 2004. - Vol. 14, № 2. - P69-70 : ил. - Библиогр.: с. 70 (14 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): KINETIC RESOLUTION -- CHLORIDE -- COMPUTATION METHODS Аннотация: The kinetic resolution of (±)-2,3-dihydro-3-methyl-4H-1,4- benzoxazine by the action of (S)-naproxen chloride was theoretically studied based on various computation methods. \\\\Expert2\\nbo\\Mendeleev Communications\\2004, v.14, p.69.pdf |
K 46 Kinetic resolution of (±)-2,3-dihydro-3-methyl-4H-1,4-benzoxazine, (±)-2-methyl-1,2,3,4-tetrahydroquinoline and (±)-2-methylindoline using N-tosyl-(S)-prolyl chloride [Text] / V. P. Krasnov, G. L. Levit, I. M. Bukrina, I. N. Andreeva, L. Sh. Sadretdinova, M. A. Koroleva, M. I. Kodess, V. N. Charushin, O. N. Chupakhin // Tetrahedron: Asymmetry . - 2003. - Vol. 14, № 14. - P1985-1988. - Bibliogr. : p. 1988 (6 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Acylation of racemic 2,3-dihydro-3-methyl-4H-1,4-benzoxazine, 2-methyl-1,2,3,4-tetrahydroquinoline and 2-methylindoline with N-tosyl-(S)-prolyl chloride resulted in their kinetic resolution with the predominant formation of (R,S)-diastereoisomeric amides, des being 80, 66 and 38%, respectively. Recrystallisation of the amides followed by acid hydrolysis gave individual (R)-enantiomers of heterocyclic amines \\\\Expert2\\nbo\\Tetrahedron Asymmetry\\2003, v.14, p.1985.pdf |
K 46 Kinetic resolution of Heterocyclic Amines using N-Tosyl-(S)-prolyl chloride [Text] : доклад, тезисы доклада / V. N. Charushin, V. P. Krasnov, G. L. Levit, I. N. Andreeva, I. M. Bukrina // XXth European Colloquium on Heterocyclic Chemistry, Stockholm,Sweden, 18-21 Aug. 2002 г. - Stockholm, 2002. - PA:7 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
1H NMR evidence for 5(4H)-oxazolones formation and racemization [Text] : доклад, тезисы доклада / O. N. Chupakhin, V. P. Krasnov, A. M. Demin, G. L. Levit, M. I. Kodess // XXth European Colloquium on Heterocyclic Chemistry, Stockholm,Sweden, 18-21 Aug. 2002 г. - Stockholm, 2002. - C:2 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
D 98 Dynamic kinetic resolution via 5(4H)-oxazolone formation [Text] : доклад, тезисы доклада / O. N. Chupakhin, V. P. Krasnov, N. Z. Solieva, E. A. Zhdanova, I. M. Bukrina, L. Sh. Sadretdinova, G. L. Levit, M. I. Kodess // XXth European Colloquium on Heterocyclic Chemistry, Stockholm,Sweden, 18-21 Aug. 2002 г. - Stockholm, 2002. - C:3 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
R 32 Reduction of (2S,4S)-4-amino-5-oxoproline derivatives using borane complexes [Text] : доклад, тезисы доклада / A. Yu. Vigorov, I. A. Nizova, L. Sh. Sadretdinova, G. L. Levit, I. N. Ganebnuikh, M. A. Ezhikova, M. I. Kodess // Fifth International Conference on Organic Chemistry for young Scientists (InterYCOS-2009) "Universities Contribution in the Organic Chemistry Progress", devoted to the 175 th anniversary of D.I.Mendeleevs birthday and 80th anniversary of the Chemistry department of St. Petersburg State University foundation, Saint-Petersburg, 22-25 june 2009 : abstr. - СПб., 2009. - P39 (1-07). - Bibliogr. : p. 40 (7 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ |
A 19 Acylactive kinetic resolution of racemic heterocyclic amines using amino acids derivatives [Text] : доклад, тезисы доклада / D. A. Gruzdev, G. L. Levit, E. N. Chulakov, L. Sh. Sadretdinova, T. V. Matveeva, E. A. Il"ichyova, V. P. Krasnov // Fifth International Conference on Organic Chemistry for young Scientists (InterYCOS-2009) "Universities Contribution in the Organic Chemistry Progress", devoted to the 175 th anniversary of D.I.Mendeleevs birthday and 80th anniversary of the Chemistry department of St. Petersburg State University foundation, Saint-Petersburg, 22-25 june 2009 : abstr. - СПб., 2009. - P45 (1-11). - Bibliogr. : p. 46 (9 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ |