A 10 A new approach to fluorinated 4(1H)-quinazolinones [Electronic resource] / A. A. Layeva, E. V. Nosova, G. N. Lipunova, T. V. Trashakhova, V. N. Charushin // Journal of Fluorine Chemistry. - 2007. - Vol. 128, № 7. - P748-754 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A new approach for the synthesis of fluorinated 1H-quinazolin-4-ones and 4-substituted quinazolines has been developed. 6-Fluoro-1H-quinazolin-4-ones were obtained by intramolecular cyclization of fluorine-containing S-ethyl N-benzoylisothioureas. Nucleophilic substitution reactions at positions 2 and 7, as well as alkylation at 1-position of quinazolinones were investigated. In addition, the synthesis of fluorine-containing 4-aminoquinazolines was carried out. \\\\Expert2\\nbo\\Journal of Fluorine Chemistry\\2007, v.128. p.748.pdf |
F 70 Fluorine-containing heterocycles. XV. Reactions of polyfluorobenzoyl isothiocyanates with amino azines and amino azoles [Electronic resource] / E. V. Nosova, G. N. Lipunova, A. A. Laeva, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2006. - Vol. 42, № 10. - P1544-1550. - Библиогр. : с. 1550 (9 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Reactions of tetra-and pentafluorobenzoyl isothiocyanates with aminoazoles and aminoazines led to the formation of fluorinated 1,3-benzothiazin-4-ones which reacted with cyclic amines in different ways. Replacement of the N=C=S fragment was observed in some reactions of polyfluorobenzoyl isothiocyanates with nucleophiles. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2006, 42 (10), 1544.pdf |
F 70 Fluorinated benzazoles and benzazines [Text] / E. V. Nosova, N. N. Mochul`skaya, S. K. Kotovskaya, G. N. Lipunova, V. N. Charushin // Heteroatom Chemistry. - 2006. - Vol. 17, № 6. - P579-594. - Библиогр. : с. 592 (103 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The review surveys the recently obtained data on the synthesis of fluorinated benzazoles and benzazines. |
F 70 Fluoro-containing heterocycles: Part XIII. Fluoro-containing derivatives of thiazolo[3,2-a]-, benzothiazolo[3,2-a]-, and benzimidazo[3,2-a]quinazolinones [Electronic resource] / E. V. Nosova, G. N. Lipunova, A. A. Laeva, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2005. - Vol. 41, № 11. - P1671-1677. - Библиогр. : с. 1677 (22 назв.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Reactions of 2-aminothiazole, derivatives of 2-aminobenzothiazole and 2-aminobenzoimidazole with polyfluorobenzoyl chlorides gave rise to acylation products that at heating in the diphenyl ether formed fluoro-containing derivatives of thiazolo[3,2- a]-, benzothiazolo[3,2- a]-, and benzimidazo[3,2- a]quinazolinone. \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2005, 41 (11), 1671.pdf |
N 85 Nosova, E. V. Cyclization of 2-halobenzoyl chlorides with dinucleophiles as a versatile approach to fused heterocycles [Electronic resource] / E. V. Nosova, G. N. Lipunova, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2004. - Vol. 53, № 6. - P1137-1152 : рис. - Библиогр.: с. 1151-1152 (103 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The review surveys methods for the construction of bi- and polycyclic nitrogen-, oxygen-, and sulfur-containing heterocycles based on reactions of 2-halobenzoyl chlorides with dinucleophiles.?? \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2004, 53 (6), 1137.pdf |
N 52 New approach to [a]-fused fluoroquinolones: the synthesis of 5-oxo-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinolines [Electronic resource] / E. Tsoi, V. N. Charushin, E. V. Nosova, G. N. Lipunova, A. V. Tkachev // Mendeleev Communications. - 2001. - Vol. 11, № 2. - P53-54 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The reaction of N-(ethoxycarbonyl)methyl substituted ethyl 6,7-difluoro-, 6,7,8-trifluoro- and 5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylates with methyl methacrylate results in the [3 + 2] adducts, hexahydropyrrolo[1,2-a]quinolones, which can be precursors of [a]-fused fluoroquinolones.?????? \\\\expert2\\nbo\\Mendeleev Communications\\2001, v.11, N 2. p.53.pdf |
F 98 Fused fluoroquinolones: synthesis and 1H and 19F NMR studies [Text] / V. N. Charushin, E. V. Nosova, G. N. Lipunova, M. I. Kodess // Journal of Fluorine Chemistry. - 2001. - Vol. 110, № 1. - P25-30. - Bibliogr. : p. 30 (19 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: New derivatives of fused fluoroquinolones bearing five aromatic rings have been obtained. The 19F NMR spectra of these pentacyclic fluoroquinolones demonstrate unusual through space 1H–19F and 19F–19F spin–spin interactions with coupling constants 6J(F, H)=2.0–3.0 Hz, 7J(F, F)=3.5–4.0 Hz and 9J(F, H)=3.0–3.5 Hz. Relative reactivities of fluorine atoms in pentacyclic fluoroquinolones in the amino-defluorination reactions are also different relative to bi- and tricyclic fluoroquinolones???? \\\\Expert2\\nbo\\Journal of Fluorine Chemistry\\2001.v.110. p. 25.pdf |
C 47 Charushin, V. N. Fluorinated derivatives of condensed heterocycles on the basis of (polyfluorobenzoyl)chlorides [Text] : доклад, тезисы доклада / V. N. Charushin, E. V. Nosova, G. N. Lipunova // XXth European Colloquium on Heterocyclic Chemistry, Stockholm,Sweden, 18-21 Aug. 2002 г. - Stockholm, 2002. - PB:4 Рубрики: ХИМИЧЕСКИЕ НАУКИ |
N 89 Novel pentacyclic fluoroquinolones [Electronic resource] / G. N. Lipunova, G. A. Mokrushina, E. V. Nosova, L. I. Rusinova, V. N. Charushin // Mendeleev Communications. - 1997. - Vol. 7, № 3. - P109-110 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Heating of ethyl 3-[betaX-(benzazol-2-yl)hydrazino]-2-(polyfluorobenzoyl)acrylates in acetonitrile with DBU yields derivatives of 4-oxo-4H-benzazolo[2’,3’:3,4][1,2,4]triazino[5,6,1-i,j]quinoline-5-carboxylic acids, representing a novel heterocyclic systems \\\\expert2\\nbo\\Mendeleev Communications\\1997, v.7, N 3. p.109.pdf |
B 43 Benzimidazo[l,2-a]pyrazolo[l,5-c]quinazoline: a novel heterocyclic system [Electronic resource] / G. N. Lipunova, G. A. Mokrushina, E. B. Granovskaya, O. M. Chasovskikh, V. N. Charushin // Mendeleev Communications. - 1996. - Vol. 6, № 1. - P15-17 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Heating of ethyl 3-[beta-(benzimidazol-2-yl)hydrazine]-2-(polyfluorobenzoyl)acrylates in acetonitrile with potassium fluoride or triethylbenzyl ammonium chloride leads to derivatives of novel heterocyclic systems of benzimidazo[l,2-a]pyrazolo- [1,5-c]quinazoline \\\\expert2\\nbo\\Mendeleev Communications\\1996, v.6, N 1. p.15.pdf |
1,3,4-Oxa(thia)diazino [i,j]-annelated quinolines: a new type of key intermediate in the synthesis of tricyclic fluoroquinolones [Electronic resource] / G. N. Lipunova, E. V. Nosova, V. N. Charushin, L. P. Sidorova, O. M. Chasovskikh // Mendeleev Communications. - 1998. - Vol. 8, № 4. - P131-132 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The synthesis of new derivatives of 1,3,4-oxa(thia)diazino[6,5,4-i,j]quinolines, which have a structure that is very similar to the ofloxacin skeleton, by intramolecular cyclizations of ethyl 3-(R-carbonylhydrazino)- and 3-(R-thiocarbonylhydrazino)-substituted 2-polyfluorobenzoyl acrylates, is described?????? \\\\expert2\\nbo\\Mendeleev Communications\\1998, v.8, N 4. p.131.pdf |
F 70 Fluorine-containing heterocycles. XVII. (Tetrafluorobrnzoyl)thioureas in the synthesis of fluorine-containing azaheterocycles [Electronic resource] / G. N. Lipunova, E. V. Nosova, A. A. Laeva, T. V. Trashakhova, P. A. Slepukhin, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2008. - Vol. 44, № 5. - P741-749 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Proceeding from (tetrafluorobenzoyl)thioureas fluorine-containing derivatives were synthesized of 1-aryl-2-ethylthioquinazolin-4-one, [1,3]benzothiazin-4-one, and also of thiazolidine and 1H-1,2,4-triazole \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2008, 44 (5), 741.pdf |
F 70 Fluoro-containing Heterocycles: V. Cyclization of 3-Azolylamino-2-polyfluorobenzoylacrylates [Electronic resource] / G. N. Lipunova, E. V. Nosova, M. I. Kodess, V. N. Charushin, Yu. A. Rozin, O. M. Chasovskikh // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2001. - Vol. 37, № 4. - P570-576 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The heating of ethyl 3-azolylamino-2-polyfluorobenzoylacrylates in acetonitrile in the presence of KF gave rise to derivatives of 1-azolyl-substituted quinolones or azolo[1,5-a]pyrimidines?? \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2001, 37 (4), 570.pdf |
F 70 Fluorine-containing heterocycles. XVI. Reactions of tetrafluorobenzoyl isothiocyanate with hydrazines and their derivatives [Electronic resource] / E. V. Nosova, G. N. Lipunova, A. A. Laeva, L. P. Sidorova, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2007. - Vol. 43, № 1. - P68-76 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorinated derivatives of 4H-1,3-benzothiazin-4-one, [1,2,4]triazolo[4,3-a]pyrimidine, [1,2,4]triazolo[3,4-b][1,3]benzazoles, and 1,5-dihydro-1,2,4-triazole-5-thione were synthesized by addition of hydrazines and their derivatives to tetrafluorobenzoyl isothiocyanate, followed by cyclization of intermediate thiosemicarbazides \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2007, 43 (1), 68.pdf |
F 70 Fluorine-Containing Heterocycles. XII. Fluorine-Containing Quinazolin-4-ones and Azolo[a]quinazolinone Derivatives [Electronic resource] / G. N. Lipunova, E. V. Nosova, A. A. Laeva, M. I. Kodess, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2005. - Vol. 41, № 7. - P1071-1080 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Methods for the synthesis of fluorine-containing derivatives of 2-imino-1,3-diphenylquinazolin-4-one, imidazo[1,2-a]quinazolin-5-one, pyrazolo[1,5-a]quinazolin-5-one, and [1,2,4]triazolo[1,5-a]quinazolin-5-one were developed on the basis of the reaction of tetrafluorobenzoyl chloride with N,N?-diphenylguanidine and aminoazoles \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2005, 41 (7), 1071.pdf |
F 70 Fluorine-containing Heterocycles. X. Acetoacetamides in the Synthesis of Fluorine-containing Chromone [Electronic resource] / G. N. Lipunova, E. V. Nosova, M. I. Kodess, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2004. - Vol. 40, № 8. - P1162-1166 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Fluorine-containing chromone-3-carboxamides were synthesized by reaction of tetra(penta)fluoro-benzoyl chlorides with acetoacetamides in dichloromethane in the presence of triethylamine. Nucleophilic substitution of fluorine atoms by amine rests in compounds synthesized was investigated \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2004, 40 (8), 1162.pdf |
F 70 Fluoro-containing Heterocycles: VI. New Derivatives of 1,3,4-Thiadiazino[6,5,4-i,j]quinoline [Electronic resource] / E. V. Nosova, G. N. Lipunova, L. P. Sidorova, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2001. - Vol. 37, № 8. - P1169-1176 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A series of new tricyclic fluoroquinolones was prepared by replacing fluorine atoms in derivatives of 2-R-8-Y-7-oxo-9,10-difluoro-7H-1,3,4-thiadiazino[6,5,4-i,j]quinoline-6-carboxylic acids. In acids and esters containing a hydrogen atom in position 8 occurred replacement of F10 by amine rests, and in compounds with a fluorine in position 8 was substituted either F8or F10 and F8depending on the amine character \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2001, 37 (8), 1169.pdf |
F 70 Fluorine-containing heterocycles. XIX. Synthesis of fluorine-containing quinazolin-4-ones from 3,1-benzoxazin-4-ones [Electronic resource] / A. A. Laeva, E. V. Nosova, G. N. Lipunova, A. V. Golovchenko, N. Yu. Adonin, V. N. Parmon, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2009. - Vol. 45, № 6. - P913-920 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Reactions of fluorine-containing 3,1-benzoxazin-4-ones with ammonium acetate, hydrazine, and heteroaromatic amines gave new 3H-, 3-amino-, and 3-hetarylquinazolin-4-ones, respectively. Differences in the conditions of formation of benzoxazinones from anthranilic acids with different fluorination patterns and in the reactions of fluorinated 3,1-benzoxazinones with nitrogen-centered nucleophiles were revealed \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2009, 45 (6), 913.pdf |
F 70 Fluorocontaining Heterocycles: IX. Derivatives of Imidazo[2,1-b][1,3]benzothiazine [Electronic resource] / G. N. Lipunova, E. V. Nosova, G. A. Mokrushina, E. G. Oglobina, G. G. Aleksandrov, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2003. - Vol. 39, № 2. - P248-256 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The heating of derivatives of benzimidazole-2-thione and imidazolidine-2-thione with tetra(penta)fluorobenzoyl chlorides in toluene or pyridine gave rise to fluorocontaining derivatives of imidazo[2,1-b][1,3]benzothiazine. The latter were studied in reactions of nucleophilic substitution of fluorine for amino groups \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2003, 39 (2), 248.pdf |
F 70 Fluorine-Containing Heterocycles. VIII. Transformations of 2-Polyfluorobenzoylacrylates Having a Thiosemicarbazide Fragment [Electronic resource] / G. N. Lipunova, E. V. Nosova, L. P. Sidorova, V. N. Charushin, O. M. Chasovskikh, A. V. Tkachev // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2002. - Vol. 38, № 12. - P1790-1796 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Depending on the conditions, 3-(4-R-thiosemicarbazido)-2-polyfluorobenzoylacrylates can be converted into the corresponding potassium salts, [1,3,4]thiadiazino[6,5,4-ij]quinolines, and pyrazole or 1,3,4-thiadiazole derivatives \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2002, 38 (12), 1790.pdf |