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Общее количество найденных документов : 17
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1.
Инвентарный номер: нет.
   


   
    Pyrrolylquinoxaline-2-one derivative as a potent therapeutic factor for brain trauma rehabilitation / E. A. Dutysheva, M. A. Mikeladze, N. D. Aksenov [и др.] // Pharmaceutics. - 2020. - Vol. 12, № 5. - С. 414
Кл.слова (ненормированные):
APOPTOSIS -- CEREBROSPINAL FLUID -- HSP70 -- SMALL MOLECULE -- TRAUMATIC BRAIN INJURY
Аннотация: Traumatic brain injury (TBI) often causes massive brain cell death accompanied by the accumulation of toxic factors in interstitial and cerebrospinal fluids. The persistence of the damaged brain area is not transient and may occur within days and weeks. Chaperone Hsp70 is known for its cytoprotective and antiapoptotic activity, and thus, a therapeutic approach based on chemically induced Hsp70 expression may become a promising approach to lower post-traumatic complications. To simulate the processes of secondary damage, we used an animal model of TBI and a cell model based on the cultivation of target cells in the presence of cerebrospinal fluid (CSF) from injured rats. Here we present a novel low molecular weight substance, PQ-29, which induces the synthesis of Hsp70 and empowers the resistance of rat C6 glioma cells to the cytotoxic effect of rat cerebrospinal fluid taken from rats subjected to TBI. In an animal model of TBI, PQ-29 elevated the Hsp70 level in brain cells and significantly slowed the process of the apoptosis in acceptor cells in response to cerebrospinal fluid action. The compound was also shown to rescue the motor function of traumatized rats, thus proving its potential application in rehabilitation therapy after TBI.

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2.
Инвентарный номер: нет.
   
   N 89


   
    Novel push-pull thieno[2,3-b]indole-based dyes for efficient dye-sensitized solar cells (DSSCs) / R. A. Irgashev, A. A. Karmatsky, G. A. Kim, G. L. Rusinov, V. N. Charushin, A. A. Sadovnikov, V. K. Ivanov, S. A. Kozyukhin, V. V. Emets, V. A. Grinberg // Arkivoc. - 2017. - Vol. 4. - P34-50
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
DYE-SENSITIZED SOLAR CELLS -- ELECTRON-RICH HETEROCYCLES -- METAL-FREE DYES -- PHOTOVOLTAIC PROPERTIES -- PUSH-PULL STRUCTURE -- THIENO[2,3-B]INDOLE
Аннотация: New metal-free sensitizers (IK 3-6), based on the thieno[2,3-b]indole ring system, bearing various aliphatic substituents at the nitrogen atom (electron-donating part), several thiophene units (π-bridge linker) and 2-cyanoacrylic acid (the electron-accepting and anchoring group) have been synthesized for application in dye-sensitized solar cells (DSSCs). The relationship between the IK dye structure and efficiency of the corresponding DSSC has been elucidated. Power conversion efficiency (PCE) up to 6.3% (short-circuit photocurrent density (JSC) 19.0 mA cm-2, open-circuit voltage (VOC) 0.59 V, and fill factor (FF) 56.4%) were obtained for the DSSC, based on 2-cyano-3-{5-[8-(2-ethylhexyl)-8H-thieno[2,3-b]indol-2-yl]thiophen-2-yl}acrylic acid (IK 3), which proved to be a highly synthetic available compound, under simulated AM 1.5 G irradiation (100 mW cm-2), thus indicating that thieno[2,3-b]indole-based organic dyes are perspective candidates for DSSCs.

\\\\Expert2\\NBO\\ARKIVOC\\2017 v.4 p.34-50.pdf
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3.
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   N 52


   
    New V-shaped push-pull systems based on 4,5-di(hetero)aryl substituted pyrimidines: their synthesis and application to the detection of nitroaromatic explosives. / E. V. Verbitskiy, A. A. Baranova, K. I. Lugovik, K. O. Khokhlov, E. M. Cheprakova, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin // ARKIVOC. - 2016. - Vol. III. - С. 360-373. - Bibliogr. : p. 370-373 (50 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PYRIMIDINES -- SYNTHESIS -- NITROAROMATIC EXPLOSIVES

\\\\expert2\\NBO\\ARKIVOC\\2016, p.360-373.pdf
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4.
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    Modification and application of 1,2,5-oxadiazolo[3,4-b]pyrazine derivatives: highlights and perspectives / Yu. A. Kvashnin, E. V. Verbitskiy, G. L. Rusinov, V. N. Charushin // Russian chemical bulletin. - 2022. - Vol. 71, № 7. - P1342-1362
Рубрики: ХИМИЧЕСКИЕ НАУКИ

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5.
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    Fluoroaromatic 2H-imidazole-based push-pull fluorophores: Synthesis, theoretical studies, and application opportunities as probes for sensing the pH in saliva / T. D. Moseev, M. V. Varaksin, E. A. Virlova [et al.] // Dyes and Pigments. - 2022. - Vol. 202. - Ст. 110251
Рубрики: ХИМИЧЕСКИЕ НАУКИ

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6.
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    Chupakhin, O. N.
    Application of electrochemical oxidative methods in the C(SP2)–H functionalization of heterocyclic compounds / O. N. Chupakhin, A. V. Shchepochkin, V. N. Charushin // Advances in heterocyclic chemistry. - 2020. - Т. 131. - P1-47
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
C-H FUNCTIONALIZATION -- ELECTROCHEMICAL OXIDATION -- GREEN CHEMISTRY -- OCDC -- SN H REACTIONS
Аннотация: New atom-economic and environmentally friendly processes should replace the traditional ways of building C–C, C–N, C–O, C–P, C–S bonds, which are usually based on the replacement of a halogen atom, and, therefore, required the preliminary modification of substrates, and the use of aggressive reagents, harsh conditions or expensive catalysts. In recent years, the direct metal-free functionalization of the C(sp2)–H bond, which provides the most efficient and low-waste pathway for molecular transformation, has attracted increasing attention. However, these transformations usually require stoichiometric amounts of chemical oxidizing agents. The modern world and its sustainable development trends are forcing the chemical industry to improve in an environmentally friendly direction and meet the requirements of “green chemistry.” In this regard, the use of electrochemical methods is extremely important. Electrochemical anodic oxidation is an ideal option for the replacement of chemical oxidizers in C–H functionalization reactions. The data on the main electrochemical methods and approaches used for the direct functionalization of the C(sp2)–H bond in heterocyclic compounds are classified and summarized in this paper.

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7.
Инвентарный номер: нет.
   
   C 57


    Chupakhin, O. N.
    Application of 1H, 13C and 15N NMR in the chemistry of 1,4-diazines [Electronic resource] / O. N. Chupakhin, V. N. Charushin, A. I. Chernyshev // Progress in Nuclear Magnetic Resonance Spectroscopy. - 1988. - Vol. 20, № 2. - С. 95-206. - Bibliogr. : p. 197-206 (202 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
1,4-DIAZINES -- 15N NMR -- 13C -- 1H

\\\\expert2\\nbo\\Progress in Nuclear Magnetic Resonance Spectroscopy\\1988. V. 20, N 2. P. 95-206.pdf
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8.
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   C 51


   
    Chelates of fluoroalkyl containing enaminoketones [Electronic resource] / V. I. Filyakova, D. L. Chizhov, E. F. Khmara, V. N. Charushin // Russian Journal of General Chemistry. - 2010. - Vol. 80, № 1. - P190-201
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Аннотация: The structure and areas of practical application of fluoroalkyl containing enaminoketone chelates with d-metals are reviewed. Synthesis of ligands and the routes to the regioisomeric enaminoketones are also considered

\\\\Expert2\\nbo\\Russian Journal of General Chemistry\\2010, V. 80, N 1, p.190.pdf
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9.
Инвентарный номер: нет.
   
   C 47


    Charushin, V. N.
    Fluoroquinolones: Synthesis and Application / V. N. Charushin, E. V. Nosova, G. N. Lipunova // Fluorine in Heterocyclic Chemistry : Издательство "Springer", 2014. - Vol. 2. - С. 111-179. - Bibliogr. : p. 176-179 (377 ref.)
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
QUINOLONE SYSTEM -- BIOLOGICAL ACTIVITY -- FLUOROQUINOLONES
Аннотация: The data on 6-fluorо-1,4-dihydroquinolin-4-oxo-3-carboxylic acids and their structural analogues accumulated in the literature for the last 10–15 years are reviewed. Synthetic approaches to the quinolone system, as well as all kind of structural modifications by incorporating substituents into 1–8 positions or by means of annelation have been discussed. The “structure-activity” relationships for antibacterial fluoroquinolones, as well as the data on other types of biological activity for the family of bi- and polycyclic fluoroquinolones are presented. The formation of complexes of fluoroquinolones with metals and their applications have been considered. The bibliography

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10.
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    Charushin, V. N.
    Chemical elements in medicine / V. N. Charushin, Y. A. Titova, E. R. Milaeva // Herald of the Russian academy of sciences. - 2020. - Vol. 90, № 2. - P229-238
Кл.слова (ненормированные):
BETA-LACTAM ANTIBIOTICS -- BORON NEUTRON CAPTURE THERAPY -- FLUOROQUINOLONES -- HETEROCYCLES
Аннотация: A brief review of chemical elements, compounds from which find application in medicine, ranging from the commonly occurring organogenic elements (carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus), composing the structure of proteins and nucleic acids of the cells of living organisms and determining the genetic transmission, to native rarely encountered organic fluorine compounds, synthetic derivatives of which have become firmly ingrained in the arsenal of modern pharmaceutical drugs, is given. Strong emphasis is put on metalloproteins, which play a significant role in the biochemistry of vitally essential processes, as well as metal compounds that are widely used in medicine. Of particular importance are the chemical elements and the isotopes, compounds of which are employed in nuclear medicine for diagnostics and treatment of a wide range of diseases, oncological and cardiovascular in particular.

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