N 89 Novel pentacyclic fluoroquinolones [Electronic resource] / G. N. Lipunova, G. A. Mokrushina, E. V. Nosova, L. I. Rusinova, V. N. Charushin // Mendeleev Communications. - 1997. - Vol. 7, № 3. - P109-110 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Heating of ethyl 3-[betaX-(benzazol-2-yl)hydrazino]-2-(polyfluorobenzoyl)acrylates in acetonitrile with DBU yields derivatives of 4-oxo-4H-benzazolo[2’,3’:3,4][1,2,4]triazino[5,6,1-i,j]quinoline-5-carboxylic acids, representing a novel heterocyclic systems \\\\expert2\\nbo\\Mendeleev Communications\\1997, v.7, N 3. p.109.pdf |
F 70 Fluoro-containing Heterocycles: VI. New Derivatives of 1,3,4-Thiadiazino[6,5,4-i,j]quinoline [Electronic resource] / E. V. Nosova, G. N. Lipunova, L. P. Sidorova, V. N. Charushin // Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). - 2001. - Vol. 37, № 8. - P1169-1176 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A series of new tricyclic fluoroquinolones was prepared by replacing fluorine atoms in derivatives of 2-R-8-Y-7-oxo-9,10-difluoro-7H-1,3,4-thiadiazino[6,5,4-i,j]quinoline-6-carboxylic acids. In acids and esters containing a hydrogen atom in position 8 occurred replacement of F10 by amine rests, and in compounds with a fluorine in position 8 was substituted either F8or F10 and F8depending on the amine character \\\\Expert2\\nbo\\Russian Journal of Organic Chemistry\\2001, 37 (8), 1169.pdf |
1,2,4-Triazino[5,6,1-i,j]quinolines: a new type of tricyclic analogs of fluoroquinolones [Electronic resource] / G. N. Lipunova, E. V. Nosova, N. N. Mochul`skaya, A. A. Andreiko, O. M. Chasovskikh, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2002. - Vol. 51, № 4. - P663-667 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The interaction of C-aryl-substituted amidrazones and S-methylisothiosemicarbazide with 3-ethoxy-2-polyfluorobenzoylacrylates results in corresponding N-(quinolin-1-yl)amidines that undergo conversion into derivatives of 1,2,4-triazino[5,6,1-i,j]quinoline by heating in acetic anhydride \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2002, 51 (4), 663.pdf |
M 78 Mochul`skaya, N. N. Three-component cyclization of hydroxylamino-substituted quinoline with reactive methylene compounds and formaldehyde: new method for the synthesis of 7-(isoxazolidin-2-yl)-6-fluoroquinolones [Electronic resource] / N. N. Mochul`skaya, L. P. Sidorova, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2002. - Vol. 51, № 11. - P2106-2108 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: A one-step procedure was developed for the synthesis of new 6-fluoro-7-(isoxazolidin-2-yl)-4-oxo-1,4-dihydroquinolines. The procedure is based on the 1,3-dipolar cycloaddition of the azomethine oxide and 1,1-disubstituted alkenes, which are generated in situ from 6-fluoro-7-hydroxylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and CH-active compounds (dialkyl malonates, ethyl acetoacetate), respectively, in the presence of formaldehyde at 100—120 °C \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2002, 51 (11), 2106.pdf |
S 98 Synthesis of fluorine-containing quinoline-2,3-dicarboxylates from products of vicarious nucleophilic substitution of hydrogen in 3-fluoronitroarenes [Electronic resource] / S. K. Kotovskaya, G. A. Zhumabaeva, V. N. Charushin, O. N. Chupakhin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2009. - Vol. 58, № 1. - P170-175 Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: The reactions of 3-fluoro-4-R-6-phenylsulfonylmethylnitrobenzenes with dimethyl fumarate or diethyl maleate in acetonitrile in the presence of an excess of K2CO3 and a catalytic amount of 18-crown-6 afforded mixtures of dialkyl 6-R-7-fluoro- and dialkyl 6-R-7-phenylsulfonylquinoline-2,3-carboxylate N-oxides, as well as dialkyl 6-R-7-fiuoro- quinoline-2,3-carboxylates (alkyl is methyl or ethyl), which were resolved by column chromatography and identified by 1H NMR spectroscopy and X-ray diffraction \\\\Expert2\\nbo\\Russian Chemical Bulletin\\2009, 58 (1), 170-175.pdf |
S 98 Synthesis and antitumor activity of fluorinated derivatives of [i,j]-annelated quinolones [Electronic resource] / G. N. Lipunova, E. V. Nosova, L. P. Sidorova, V. N. Charushin // Pharmaceutical Chemistry Journal. - 2011. - Vol. 45, № 4. - P208-210 : ил. - Bibliogr. : p. 210 (7 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Аннотация: Tri- and pentacyclic fluoroquinolones were synthesized by intramolecular cyclization of the corresponding 3-hydrazinopolyfluorobenzoylacrylates followed by substitution of fluorine atoms by amine residues. The antitumor activity of the resulting compounds was studied at the National Cancer Institute using cultures of 60 cell lines of nine groups, including leukemia, lung tumor, large intestine tumor, CNS tumor, melanoma, ovary tumor, renal tumor, prostate tumor, and breast tumor. Relationships between structure and antitumor activity were analyzed. In vivo experimental data from hollow fiber tests are presented for two derivatives \\\\Expert2\\nbo\\Pharmaceutical Chemistry Journal\\2011, 45 (4), 208.pdf |
U 62 Unusual transformations of lithium enolate of ethyl 4,4,4-trifluoro-3-oxobutanoate [Электронный ресурс] / N. S. Boltacheva, P. A. Slepukhin, D. L. Chizhov, D. S. Yachevskii, V. I. Filyakova, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2012. - Vol.61, №3. - P563-567 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): LITHIUM -- ENOLATES -- UNUSUAL REACTIONS Аннотация: The present paper describes unusual reactions of lithium enolate of ethyl 4,4,4-trifluoro-3-oxobutanoate with ammonium acetate and 1-aminonaphthalene. These reactions produce 4-amino-2,6-bis(trifluoromethyl)pyridine and 4-trifluoromethyl-2-[(Z)-1,1,1-trifluoroprop-1-en-2-ol-1-yl]benzo[h]quinoline, respectively. The reaction of 1,1,7,7,7-hexafluoroheptane-2,4,6-trione hydrate with 1-naphthylamine gives a mixture of 4-trifluoromethyl-2-[(Z)-1,1,1-trifluoroprop-1-en-2-ol-1-yl]benzo[h]quinoline and N,N′-bis(naphth-1-yl)-2,6-bis(trifluoromethyl)pyridine-4(1H)-imine, respectively \\\\Expert2\\NBO\\Russian Chemical Bulletin\\2012, 61 (3), 563-567.pdf |
F 70 Fluorine containing quinoline and quinoxaline styryl derivatives: [Electronic resource] / E. V. Nosova, T. V. Trashakhova, V. S. Ustyugov, N. N. Mochul`skaya, M. S. Valova, G. N. Lipunova, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2011. - Vol.60, №5. - С. 942-947. - Bibliogr. : p. 946-947 (25 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): STYRYLBENZAZINES -- PHOTOLUMINESCENCE -- 6,7-DIFLUOROQUINALDINE Аннотация: (E)-2-Styryl-substituted 6,7-difluoroquinolines and quinoxalines were synthesized by the condensation of the corresponding 2 methylbenzazines with aromatic aldehydes. Photolumines cence of the synthesized 6,7 difluoro 2 styrylbenzazines was studied \\\\expert2\\NBO\\Russian Chemical Bulletin\\2011, 60 (5), 942-947.pdf |
8,9,10-Trifluoro-6-oxo-6H-pyrido[1,2-a]quinoline-5-carbonitrile in the synthesis of novel 1-heteryl-3,3-dimethyl-3,4-dihydroisoquinolines [Electronic resource] / T. S. Vshivkova, Yu. V. Shklyaev, E. V. Nosova, G. N. Lipunova, V. N. Charushin // Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). - 2012. - Vol.61, №8. - С. 1650-1652 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): 3,4-dihydroisoquinolines -- THREE-COMPONENT CONDENSATION -- ISOBUTYRALDEHYDE Аннотация: 3,4-Dihydroisoquinolines containing the 8,9,10-trifluoro-6H-pyrido[1,2-a]quinolin-6-one substituent in position 1 were obtained by three-component reactions between arenes, isobutyraldehyde, and 8,9,10-trifluoro-6-oxo-6H-pyrido[1,2-a]quinoline-5-carbonitrile in H2SO4 \\\\expert2\\NBO\\Russian Chemical Bulletin\\2012, 61 (8), 1650-1652.pdf |
L 79 Lipunova, G. N. Structural, Optical Properties, and Biological Activity of Complexes Based on Derivatives of Quinoline, Quinoxaline, and Quinazoline with Metal Centers from Across the Periodic Table [Electronic resource] / G. N. Lipunova, E. V. Nosova, V. N. Charushin // Comments on Inorganic Chemistry. - 2014. - Vol.34, № 5-6. - С. 142-177. - Bibliogr. : p. 173-177 (88 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): OPTICAL PROPERTIES -- BIOLOGICAL ACTIVITY -- QUINOLINE \\\\expert2\\nbo\\Comments on Inorganic Chemistry\\2014. v. 34, N 5-6. P. 142-177.pdf |
C 98 Cyclization of n-alkylazinium cations with bisnucleophiles. 5. Cyclic adducts and recyclization products in the reactions of benzodiazinium cations with imido esters [Electronic resource] / O. N. Chupakhin, V. N. Charushin, L. M. Naumova, A. I. Rezvukhin, N. A. Klyuev // Chemistry of Heterocyclic Compounds. - 1981. - Vol. 17, № 11. - P1134-1138. - Bibliogr. : p. 1138 (23 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): METHYLENE GROUP -- BENZODIAZINIUM CATIONS -- ESTERS Аннотация: The reaction of imido esters that contain an active methylene group with four isomeric benzodiazinium cations, viz., the 1-methylquinoxalinium, 2-methylcinnolinium, 3-methylquinazolinium, and 2-methylphthalazinium cations, was investigated. The 1-methylquinoxalinium cation reacts with imido esters via a scheme involving anionic [3- +2]-cycloaddition to form tetrahydropyrrolo[2,3-b]quinoxalines. The 2-methylcinnolinium cation forms an adduct with an annelated pyrrole ring. Under the influence of imido esters, the 3-methylquinazolinium cation undergoes recyclization to a 2,3-disubstituted quinoline. The 2-methylphthalazinium cation is inert in this reaction \\\\expert2\\nbo\\Chemistry of Heterocyclic Compounds\\1981, v.17, N 11, p.1134.pdf |
D 62 Direct nuclophilic C-H functionalization of azines and their N-oxides by lithium derivatives of aldonitrones [Electronic resource] / M. V. Varaksin, I. A. Utepova, O. N. Chupakhin, V. N. Charushin // Tetrahedron. - 2015. - Vol. 71, №38. - С. 7077-7082. - Bibliogr. : p. 7082 (23 ref.) Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): DIPOLE-STABILIZED CARBANIONS -- ORGANIC-SYNTHESIS -- CHEMICAL-PROPERTIES; Аннотация: Novel ligands of the azine family for complexing with metals have been obtained as a result of the uncatalyzed C-C coupling reactions of quinoline, quinoxaline, 1,10-phenantroline, and their N-oxides with (1-oxido-3-phenyl-1,4-diazaspiro[4.5]deca-1,3-dien-2-yl)lithium \\\\expert2\\nbo\\Tetrahedron\\2015, v. 71 , p. 7077-7082.pdf |
Mochulskaya, N. N. Antiviral agents – benzazine derivatives / N. N. Mochulskaya, E. V. Nosova, V. N. Charushin // Chemistry of heterocyclic compounds. - 2021. - Vol. 57. - С. 374–382 Рубрики: ХИМИЧЕСКИЕ НАУКИ Кл.слова (ненормированные): BENZAZINES -- QUINAZOLINE -- QUINOLINE -- QUINOXALINE Аннотация: The review outlines the results of studies of the antiviral activity of quinoline, quinoxaline, and quinazoline derivatives published over the past 5 years. The supplied data indicate the enormous potential of benzazines for the design of effective antiviral drugs. |