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1.
Инвентарный номер: нет.
   

   
    2-Thiomorpholino-5-aryl-6 H-1,3,4-thiadiazine hydrobromides and their ability to inhibit nonenzymatic protein glycosylation / L. P. Sidorova, T. A. Tseitler, V. V. Emel’yanov [et al.] // Pharmaceutical Chemistry Journal. - 2017. - Vol. 51, № 1. - P9-12
ББК 54
Рубрики: ХИМИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
GLYCOSYLATION -- ESTERIFICATION -- GLYCOSYL COMPOUNDS -- DEGLYCOSYLATION -- ?-HALOGENACETOPHENONES -- 1,3,4-THIADIAZINE -- 4-MORPHOLINE THIOSEMICARBAZIDES -- CYCLOCONDENSATION -- NONENZYMATIC PROTEIN GLYCOSYLATION
Аннотация: Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.

\\\\Expert2\\NBO\\Pharmaceutical Chemistry Journal\\2017 v.51 p.9-12.pdf
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2.
Инвентарный номер: нет.
   
   A 10

   
    A new experimental model of hemolytic anemia after butoxyethanol and the study of its immunology / V. A. Chereshnev, P. V. Kosareva, E. I. Samodelkin, L. V. Sivakova // Hellenic Journal of Nuclear Medicine. - 2014. - January-April. - P7-10. - Bibliogr. : p. 10 (12 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
RATS - AUTOIMMUNITY BUTOXYETHANOL -- HEMOLYTIC ANEMIA
Аннотация: 2-butoxyethanol (C6H14O2) is widely used in many industrial reagents; according to the in vitro data it was established that 2- butoxyethanol metabolites are strong haemolytic poisons. Ghanayem B.I., Sullivan Ch.A. (1993) investigated in vitro the effect of BE on the red blood cells of 10 species of mammals, including humans. In this study, the authors established the species specificity with regard to the development of hemolytic anemia under the effect of butoxyethanol [4]. In the context of the available data, creation of experimental model based on the introduction of animal butoxyethanol is taking place. Since the druginduced hemolytic anemia is formed at the adjacency of toxic and autoimmune forms, the study of immunology of any toxic anemia is of great interest. Objective: to develop a new experimental model of hemolytic anemia after butoxyethanol and to study its immunology. In conclusion, the proposed model of hemolytic anemia after butoxyethanol may be used in the experimental and preclinical studies. The intraperitoneal administration of butoxyethanol provokes an autoimmune response directed against own red blood cells. The intraperitoneal administration of butoxyethanol to experimental animals is accompanied by a reduction of the lymphoid tissue that corresponds to the appropriate response to stress in the central and peripheral organs of immunogenesis

\\\\expert2\\nbo\\Hellenic Journal of Nuclear Medicine\\2014. P. 7-10.pdf
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3.
Инвентарный номер: нет.
   
   A 10

   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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4.
Инвентарный номер: нет.
   

   
    Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease : doi.org/10.3390/antib10010009 / I. A. Pashnina, I. M. Krivolapova, T. V. Fedotkina [et al.] // Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Antibodies. - 2021. - Vol. 10, № 1. - Ст. 9.pdf
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5.
Инвентарный номер: нет.
   

   
    Antinuclear autoantibodies in healthy individuals: autoimmunity is not a synonym of autoimmune disease / I. A. Pashnina, I. M. Krivolapova, T. V. Fedotkina [et al.] // Preprints. - 2020. - 28 Oct. - Ст. 2020100591. - 27 p.
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Аннотация: Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

\\\\Expert2\\NBO\\Электрон. библиотека (Отеч.периодика)\\Черешнев В. А\\Preprints 2020 Ст. 2020100591.pdf
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6.
Инвентарный номер: нет.
   

   
    Checking gene expression profile associated with IRF7 and UNC93B deficient patient peripheral blood mononuclear cells infected with pH1N1 influenza virus / K. Shinwari, G. Liu, M. A. Bolkov [et al.] // AIP Conference Proceedings. - 2022. - Vol. 2390, № 1. - Ст. 030089
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
VIRUSES -- MICROARRAYS -- GENOMICS
Аннотация: An innate immune defect is a defect in the innate immune response that reduces the response to infection, this can occurs in genes important for activation regulation and proliferation of the innate immune cells or pathways important for the function of innate immunity. The purpose of this study was to identify novel biomarkers of interferon Receptor 7 through bioinformatics analysis and elucidate the possible molecular mechanism. The GSE 66486 datasets containing microarray data from IRF7 and UNC93B patients and healthy controls were downloaded from the GEO database and analyzed by the GEO2R web tool to obtain different expressed genes (DEGs). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI), and Biological Networks Gene Oncology tool (BiNGO) were then performed to elucidate the molecular mechanism of IRF7. A total of 490 DEGs were identified, of which 14 were hub genes, and involved in ribosome biogenesis, rRNA processing, gene expression, mRNA processing, nuclear lumen, intracellular non-membrane-bounded organelle, nucleoplasm, small-subunit processome, antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes. Antigen processing and presentation pathway, and ribosome biogenesis in eukaryotes possibly form the basis of IRF7 or UNC93B disorders, while our study provides a list of genes and pathways that are disrupted in IRF7/UNC93B, which has the potential to be used in the clinic for diagnosis and targeted therapy of such disorders in future.

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7.
Инвентарный номер: нет.
   
   C 51

    Chereshnev, V. A.
    Beta-endorphin as the endogenous regulator of immune processes / V. A. Chereshnev, S. V. Gein // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova. - 2009. - Vol. 95, № 12. - P1279-1290
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
BETA ENDORPHIN -- OPIATE RECEPTOR -- ADAPTIVE IMMUNITY
Аннотация: Endogenous opioid peptides represent the group of bioregulatory factors possessing a wide range of biologically active effects. One of most essential functions of endogenous opioids appears to be the realization of cellular interaction between nervous and immune systems. Beta-endorphin is a peptide hormone that is the most active and multi-functional representative of the opioid peptide family. This review summarizes current observations on the nature ofbeta-endorphin, its production by the immune system cells, opiate receptor structure and expression, as well as the peptide effect on the processes of cellular activation, proliferation, and differentiation in innate and adaptive immunity

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8.
Инвентарный номер: нет.
   
   C 51

    Chereshnev, V. A.
    Diagnostic value of studying creatinine in abdominal exudates [] / V. A. Chereshnev, D. Yu. Sosnin, N. A. Zubareva // Klinichescheskaya Laboratornaya Diagnostika . - 2010. - №3. - С. 11-14
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CREATININE -- EXUDATES -- RENAL FAILURE
Аннотация: The levels of creatinine in serum and peritoneal exudate were studied in 77 patients with acute surgical abdominal diseases. It has been found that the exudate concentration of this compound is mainly determined by its level in the serum, which allows the exudate creatinine to be studied for the diagnosis of renal failure. The creatinine concentration in the abdominal exudate in relation to that in the serum varies in urinary tract injury and in the early hours after abdominal sanitation in peritonitis. Exudate creatinine concentration increases (by 2.7-fold or more) require that the urinary tract should be revised to reveal its injury. Creatinine levels in the exudate can be determined not earlier than 8 hours after abdominal lavage. The determination of creatinine concentrations in the peritoneal exudate is a non-invasive and informative tool that enhances the quality of laboratory monitoring in emergency abdominal surgery

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9.
Инвентарный номер: нет.
   
   C 51

    Chereshnev, V. A.
    Synchronization, desynchronization, and resynchronization as mechanisms for the formation of variable polyrhythmicity in biological and geophysical systems / V. A. Chereshnev, A. G. Gamburtsev , S. I. Stepanova // Doklady Earth Sciences. - 2017. - Vol. 472, № 1. - P123-125
ББК 001.2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Аннотация: The variable polyrhythmicity observed in natural, technical, and humanitarian spheres can be the result of mutual desynchronization of conjugate rhythmic processes. One example of desynchronization in medicine is fibrillations of heart ventricles. To bring a patient out of this state, electroshock is applied, which frequently leads to defibrillation and recovery of normal heart rhythm (resynchronization). This phenomenon has analogies in other fields of science. It is known that lunar–solar tides cause subsurface seismic noise. We give an example of detecting such noise in the Ashkhabad seismic survey area. This noise can appear and disappear, and the reason may be certain shock impacts, in particular, earthquakes. Similar results have been obtained in studying lunar seismicity, where tidal phenomena are more strongly pronounced than on Earth.

\\\\Expert2\\NBO\\Doklady Earth Sciences\\2017 v. 474 p. 126-128.pdf
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10.
Инвентарный номер: нет.
   
   C 51

    Chereshnev, V. A.
    Variable polyrhythmicity of processes in nature and society / V. A. Chereshnev, S. I. Stepanova, A. G. Gamburtsev // Herald of the Russian Academy of Sciences. - 2017. - Vol. 87, № 2. - P172-180. - Bibliogr. : p. 180 (15 ref.)
ББК 50 + 61
Рубрики: ЕСТЕСТВЕННЫЕ НАУКИ--НАУКА ОБ ОКРУЖАЮЩЕЙ СРЕДЕ--ЭКОЛОГИЯ В ЦЕЛОМ--КОНФЕРЕНЦИИ
   ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
VARIABLE POLYRHYTHMICITY -- RHYTHMS IN NATURE AND SOCIETY -- TIME-SPECTRAL ANALYSIS
Аннотация: The authors discuss possible causes of the variable polyrhythmicity of processes in nature and society, particularly in geophysics. It may be caused by desynchronization or resynchronization of processes that manifest themselves as a result of a shock impact on the geological environment, for example, in the form of an earthquake. Medical parameters are considered for which de- and resynchronization of rhythmic processes in the human organism are known, as well as geophysical processes, including underground noise of tidal origin and the seismicity of the Moon.

\\\\expert2\\NBO\\Herald of the Russian Academy of Sciences\\2017. V. 87, N 2. P. 172-180.pdf
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