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1.
Инвентарный номер: нет.
   
   N 52


   
    New capacities of the phagocytic test used in pediatric phthisiology / L. P. Sanakoeva, A. D. Koriukina, V. A. Chereshnev, V. A. Aksenova // Probl Tuberk Bolezn Legk . - 2004. - №6. - P42-48
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
BCG VACCINE -- LUNG TUBERCULOSIS -- PHAGOCYTOSIS
Аннотация: The paper presents the results of a study of the phagocytic activity of leukocytes (PAL) in 98 healthy children, vaccinated with BCG, in different periods after immunization and in 68 children with tuberculous infection (39 children with tuberculosis and 29 Mycobacterium tuberculosis-infected children). An improved procedure for studying PAL was used, in which sheep erythrocytes of two types ("antigenic" and those with a complex of antigen + antibody + antigen), which may differentiate the phase of bacteremia and immune synthesis, were used as an object for phagocytes. In the limited number of vaccinated children, bacteremia were detectable up to 9 months; the phase of immune synthesis continued in most children up to 3 years. The study has demonstrated that a complex of phagocytic tests may be used for the early diagnosis of tuberculous infection, for the evaluation of a tuberculous process and antituberculous immunity

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2.
Инвентарный номер: нет.
   
   T 44


   
    The blood system and the organism adaptation to extreme factor / V. A. Chereshnev, B. G. Lushkov, M. N. Sumin, N. V. Tyumentseva, I. S. Khramtsova, I. G. Danilova // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk . - 2004. - Vol.90, №10. - P1193-1202
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HEMOGLOBIN -- HEMATOPOIESIS -- LEUKOCYTE
Аннотация: The formation of blood system adoptive reaction in many cases is defined by the type of action and the condition of hemopoietic inductive microenvironment: hemodynamics of hemopoietic tissue, functional conditions of bone marrow macrophages, mast cells and glycosaminoglycans content. The shift in hemodlobin fraction occurs in extreme conditions requiring an increased gas transport by the blood. In case of tissue lesion, lymphocytes stimulate their regeneration. Morphogenetic function of lymphoid cells may be alerted by immunomodulators. Blood cells participate in angiogenesis, and this property may be used for vessel grafts production

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3.
Инвентарный номер: нет.
   
   Ч-46


    Черешнев, В. А.
    Иммунологические и генетические факторы бесплодия у жителей Екатеринбурга / В. А. Черешнев, И. В. Рыбина, Я. Б. Бейкин // Аллергология и иммунология. - 2006. - Т. 7, № 2. - С. 230-234. - Библиогр.: с. 234 (22 назв.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
БЕСПЛОДИЕ -- ГЕНЕТИЧЕСКИЕ ФАКТОРЫ -- ИММУНОЛОГИЧЕСКИЕ ФАКТОРЫ
Аннотация: Investigation of the degree of HLA class I antigens sharing in couples with infertility, testing for anti-spermal antibodies in both partners, anti- phosfolipid and anti-HLA antibodies in women demonstrated the primary role of immunological factors. The chromosomal abnormalities are less important but have to be considered in determination of infertility causes.

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Аллергология и иммунология\\2006-Vol7-#2_pp230-234.pdf
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4.
Инвентарный номер: нет.
   
   Ч-46


    Черешнев, В. А.
    Неинструментальное определение стрептококков группы А / В. А. Черешнев, М. Б. Раев // Вестник Уральской медицинской академической науки. - 2008. - № 6. - С. 41-43. - Библиогр.: с. 43 (15 назв.)
ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
СТРЕПТОКОККИ ГРУППЫ А -- ДИАГНОСТИКА МЕДИЦИНСКАЯ
Аннотация: The analytical system for the determination of the group-A streptococci (SGA) has been constructed. The designed diag-nosticum does not depend on hardware, i.e. it belongs to the group of so-called non-instrumental systems. The suggested pattern in realized based on the original conjugate (diagnostic reagent) that is synthesized on the basis of covalent binding of polyclonal antibodies against group-A streptococci with colloid carbon particles; this conjugate possesses the ability to bind specifically to appropriate ligand. Due to high absorbance of such conjugates in the visible light region it is possible to make direct visual determination of SGA in a sample under study. The reaction is manifested in a form of black dots on a solid phase working surface. The system could be arranged either in the form of direct determination or in a sandwich-test variant. Such analytical systems could be an efficient tool for dispensary, hospital, and pre-clinical testing including extreme clinical and epidemic situations, as well as these could be applied in different kits for home and field diagnostics

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Вестник Уральской медицинской академической науки\\2008. № 4. С. 41-43.pdf
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5.
Инвентарный номер: нет.
   
   C 51


    Chereshnev, V. A.
    Beta-endorphin as the endogenous regulator of immune processes / V. A. Chereshnev, S. V. Gein // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova. - 2009. - Vol. 95, № 12. - P1279-1290
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
BETA ENDORPHIN -- OPIATE RECEPTOR -- ADAPTIVE IMMUNITY
Аннотация: Endogenous opioid peptides represent the group of bioregulatory factors possessing a wide range of biologically active effects. One of most essential functions of endogenous opioids appears to be the realization of cellular interaction between nervous and immune systems. Beta-endorphin is a peptide hormone that is the most active and multi-functional representative of the opioid peptide family. This review summarizes current observations on the nature ofbeta-endorphin, its production by the immune system cells, opiate receptor structure and expression, as well as the peptide effect on the processes of cellular activation, proliferation, and differentiation in innate and adaptive immunity

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6.
Инвентарный номер: нет.
   
   R 87


    Rozental', O. M.
    A normative model of balanced nature management [Electronic resource] / O. M. Rozental', V. A. Chereshnev // Russian Journal of Ecology. - 2010. - Vol. 41, № 4. - P356-363. - Bibliogr. : p. 363 (13 ref.)
ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
MEASURING CONTROL -- TRACEABILITY -- VARIABILITY OF CONTROLLED PARAMETERS
Аннотация: The risk of erroneous regulation in multilevel normative environmental chains, at the federal, regional, and lower levels, down to the corporate one, has been studied. This risk has been demonstrated to increase unacceptably rapidly in the framework of the existing system of "unconditional acceptance" of normative standards. To mend the situation, it is necessary to use the "conditional acceptance" model by regarding post hoc decisions made at higher levels as a priori ones at the next (lower) levels. A strategy of environmentally and economically balanced corporate regulation of nature management through minimization of the losses resulting from both excessive caution and breaching the existing regulations has been proposed. This system, combined with the European approach to nature conservation, requires that the "riskless" regulation should be abandoned and is expected to improve the parameters of nature management quality by three to four orders of magnitude

\\\\expert2\\NBO\\Russian Journal of Ecology\\2010. V. 41, N 4. P. 356-363.pdf
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7.
Инвентарный номер: нет.
   
   A 10


   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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8.
Инвентарный номер: нет.
   
   C 51


    Chereshnev, V. A.
    Diagnostic value of studying creatinine in abdominal exudates [] / V. A. Chereshnev, D. Yu. Sosnin, N. A. Zubareva // Klinichescheskaya Laboratornaya Diagnostika . - 2010. - №3. - С. 11-14
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
CREATININE -- EXUDATES -- RENAL FAILURE
Аннотация: The levels of creatinine in serum and peritoneal exudate were studied in 77 patients with acute surgical abdominal diseases. It has been found that the exudate concentration of this compound is mainly determined by its level in the serum, which allows the exudate creatinine to be studied for the diagnosis of renal failure. The creatinine concentration in the abdominal exudate in relation to that in the serum varies in urinary tract injury and in the early hours after abdominal sanitation in peritonitis. Exudate creatinine concentration increases (by 2.7-fold or more) require that the urinary tract should be revised to reveal its injury. Creatinine levels in the exudate can be determined not earlier than 8 hours after abdominal lavage. The determination of creatinine concentrations in the peritoneal exudate is a non-invasive and informative tool that enhances the quality of laboratory monitoring in emergency abdominal surgery

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9.
Инвентарный номер: нет.
   
   C 51


    Chereshnev, V. A.
    [Fundamental-applied aspects of systemic inflammation in terms of physiologic and typical pathological process]. / V. A. Chereshnev, E. I. Gusev, N. V. Zotova // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk . - 2010. - Vol.96, №7. - С. 696-707
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
PATHOLOGY -- PATHOPHYSIOLOGY -- BIOLOGICAL MODEL
Аннотация: The concept of systemic inflammatory response syndrome (SIRS) by sepsis as well as quality of SIRS criteria, classification, and PIRO system has been a subject to analytical criticism in terms of theory of physiologic and typical pathological process. It has been disclosed SIRS can be considered only as the syndrome, that solves particular clinical tasks, but not as a basic model of pathogenesis of critical states. In authors' opinion it is more correctly to discuss systemic inflammation as a typical pathologic process that appears as a complex of one or another "resuscitation" syndrome in a clinical course

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10.
Инвентарный номер: нет.
   
   F 33


   
    Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE
Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation

\\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf
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