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 Найдено в других БД:Каталог книг и продолжающихся изданий (30)Каталог препринтов УрО РАН (1975 г. - ) (1)Нанотехнологии (1)Труды Института высокотемпературной электрохимии УрО РАН (35)Труды Института истории и археологии УрО РАН (2)Труды сотрудников Института органического синтеза УрО РАН (33)Труды сотрудников Института теплофизики УрО РАН (112)Труды сотрудников Института химии твердого тела УрО РАН (70)Расплавы (36)Публикации Чарушина В.Н. (9)Каталог библиотеки ИЭРиЖ УрО РАН (8)Библиометрия (2)
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Общее количество найденных документов : 23
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1.
Инвентарный номер: нет.
   
   E 97

   
    Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis / V. A. Chereshnev, L. V. Gankovskaya, L. V. Koval'chuk [et al.] // Bulletin of experimental biology and medicine. - 2012. - Vol. 153, № 2. - P236-239. - Bibliogr. : p. 239 (11 ref.)
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
INNATE IMMUNITY -- HERPETIC INFECTION -- KERATITIS
Аннотация: The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and beta-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus

\\\\expert2\\NBO\\Bulletin of Experimental Biology and Medicine\\2012, v.153, N 2, p. 236-239.pdf
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2.
Инвентарный номер: нет.
   
   R 30

   
    Reaction diffusion modelling of interferon distribution in secondary lymphoid organs / G. Bocharov, A. Danilov, Y. Vassilevski [et al.] // Mathematical modelling of natural phenomena. - 2011. - Vol. 6, № 7. - P13-26
ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
SYSTEMS -- RECIRCULATION -- LYMPHOCYTES
Аннотация: This paper proposes a quantitative model of the reaction-diffusion type to examine the distribution of interferon-alpha (IFN alpha) in a lymph node (LN). The numerical treatment of the model is based on using an original unstructured mesh generation software Ani3D and nonlinear finite volume method for diffusion equations. The study results in suggestion that due to the variations in hydraulic conductivity of various zones of the secondary lymphoid organs the spatial stationary distribution of IFN alpha is essentially heterogeneous across the organs. Highly protected domains such as sinuses, conduits, co-exist with the regions in which where the stationary concentration of IFN alpha is lower by about 100-fold. This is the first study where the spatial distribution of soluble immune factors in secondary lymphoid organs is modelled for a realistic three-dimensional geometry

\\\\expert2\\nbo\\Mathematical Modelling and Natural Phenomena\\2011. Vol.6, №7. С. 13-26.pdf
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3.
Инвентарный номер: нет.
   
   R 87

    Rozental', O. M.
    A normative model of balanced nature management [Electronic resource] / O. M. Rozental', V. A. Chereshnev // Russian Journal of Ecology. - 2010. - Vol. 41, № 4. - P356-363. - Bibliogr. : p. 363 (13 ref.)
ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
MEASURING CONTROL -- TRACEABILITY -- VARIABILITY OF CONTROLLED PARAMETERS
Аннотация: The risk of erroneous regulation in multilevel normative environmental chains, at the federal, regional, and lower levels, down to the corporate one, has been studied. This risk has been demonstrated to increase unacceptably rapidly in the framework of the existing system of "unconditional acceptance" of normative standards. To mend the situation, it is necessary to use the "conditional acceptance" model by regarding post hoc decisions made at higher levels as a priori ones at the next (lower) levels. A strategy of environmentally and economically balanced corporate regulation of nature management through minimization of the losses resulting from both excessive caution and breaching the existing regulations has been proposed. This system, combined with the European approach to nature conservation, requires that the "riskless" regulation should be abandoned and is expected to improve the parameters of nature management quality by three to four orders of magnitude

\\\\expert2\\NBO\\Russian Journal of Ecology\\2010. V. 41, N 4. P. 356-363.pdf
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4.
Инвентарный номер: нет.
   
   F 33

   
    Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number / G. Bocharov, J. B. Quiel, T. B. Luzyanina [и др.] // Proceedings of the National Academy of Sciences of the United States of America. - 2011. - Vol. 108, № 8. - С. 3318-3323
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
PARAMETER ESTIMATION -- TIME DELAY -- BROXURIDINE
Аннотация: The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per mouse. The results suggested inhibition of precursor expansion either by competition for specific antigen-presenting cells or by the action of other antigen-specific cells in the same microenvironment as the most likely explanation. Several molecular mechanisms potentially accounting for such inhibition were examined and rejected. Here we adopt a previously proposed concept, "feedback-regulated balance of growth and differentiation," and show that it can explain the observed findings. We assume that the most differentiated effectors (or memory cells) limit the growth of less differentiated effectors, locally, by increasing the rate of differentiation of the latter cells in a dose-dependent manner. Consequently, expansion is blocked and reversed after a delay that depends on initial PN, accounting for the dependence of the peak of the response on that number. We present a parsimonious mathematical model capable of reproducing immunization response kinetics. Model definition is achieved in part by requiring consistency with available BrdU-labeling and carboxyfluorescein diacetate succinimidyl ester (CFSE)-dilution data. The calibrated model correctly predicts FE as a function of PN. We conclude that feedback-regulated balance of growth and differentiation, although awaiting definite experimental characterization of the hypothetical cells and molecules involved in regulation, can explain the kinetics of CD4 T-cell responses to antigenic stimulation

\\\\expert2\\nbo\\PNAS\\2011. - Vol.108, №8. - С. 3318-3323.pdf
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5.
Инвентарный номер: нет.
   
   A 10

   
    A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections. / G. Bocharov, R. Züst, L. Cervantes-Barragan [et al.] // PLOS pathogens. - 2010. - Vol. 6, № 7. - P1-15 : рис., a-табл. - Bibliogr. : p. 14-15 (52 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ANTIVIRUS AGENT -- DENDRITIC CELL -- ALLERGY AND IMMUNOLOGY
Аннотация: Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the analysis of the structure, dynamics and operating principles of virus-host interactions which constrain the initial spread of the pathogen. Using high-resolution experimental data sets coming from the well-described mouse hepatitis virus (MHV) model, we first calibrated basic modules including MHV infection of its primary target cells, i.e. pDCs and macrophages (Mphis). These basic building blocks were used to generate and validate an integrative mathematical model for in vivo infection dynamics. Parameter estimation for the system indicated that on a per capita basis, one infected pDC secretes sufficient type I IFN to protect 10(3) to 10(4) Mphis from cytopathic viral infection. This extremely high protective capacity of pDCs secures the spleen's capability to function as a 'sink' for the virus produced in peripheral organs such as the liver. Furthermore, our results suggest that the pDC population in spleen ensures a robust protection against virus variants which substantially down-modulate IFN secretion. However, the ability of pDCs to protect against severe disease caused by virus variants exhibiting an enhanced liver tropism and higher replication rates appears to be rather limited. Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs

\\\\expert2\\nbo\\PLoS Pathogens\\2010. - Vol.6, № 7. - С. 1-15 .pdf
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6.
Инвентарный номер: нет.
   
   C 51

    Chereshnev, V. A.
    [Fundamental-applied aspects of systemic inflammation in terms of physiologic and typical pathological process]. / V. A. Chereshnev, E. I. Gusev, N. V. Zotova // Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk . - 2010. - Vol.96, №7. - С. 696-707
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
PATHOLOGY -- PATHOPHYSIOLOGY -- BIOLOGICAL MODEL
Аннотация: The concept of systemic inflammatory response syndrome (SIRS) by sepsis as well as quality of SIRS criteria, classification, and PIRO system has been a subject to analytical criticism in terms of theory of physiologic and typical pathological process. It has been disclosed SIRS can be considered only as the syndrome, that solves particular clinical tasks, but not as a basic model of pathogenesis of critical states. In authors' opinion it is more correctly to discuss systemic inflammation as a typical pathologic process that appears as a complex of one or another "resuscitation" syndrome in a clinical course

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7.
Инвентарный номер: нет.
   
   M 39

   
    Mathematical modelling of mutant accumulation kinetics in a cloned viral population [Electronic resource] / A. V. Novoselov, A. B. Lozhnikov, V. A. Chereshnev, A. G. Sergeev, A. V. Kim, E. Tu. Gusev, V. G. Pimenov // Russian Journal of Numerical Analysis and Mathematical Modelling. - 2004. - Vol. 19, № 4. - P293-304. - Bibliogr. : p. 304 (18 ref.)
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
CELLS -- LINEAR EQUATIONS -- MATHEMATICAL MODELS
Аннотация: The aim of this paper was to construct the mathematical model of the kinetics of non-hemagglutinating mutant accumulation in the cloned population of hemagglutinating echovirus 11 and to verify the model adequacy by comparing the results of biological and numerical experiments

\\\\expert2\\NBO\\Russian Journal of Numerical Anal. and Math. Modelling\\2004. V. 19, N. 4. P. 293-304.pdf
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8.
Инвентарный номер: нет.
   
   C 51

    Chereshnev, V. A.
    Systemic inflammation: A myth or reality / V. A. Chereshnev, E. Yu. Gusev , L. N. Yurchenko // Vestnik Rossijkoj Akademii Nauk . - 2004. - Vol.74, №3. - P219-225
ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
INFLAMED LYMPH-NODES -- BIOLOGICAL MODEL -- IMMUNE COMPLEX

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9.
Инвентарный номер: нет.
   
   P 32

   
    Pathogenesis and treatment of HIV infection: The cellular, the immune system and the neuroendocrine systems perspective / V. A. Chereshnev, G. Bocharov, S. Bazhan [et al.] // International Reviews of Immunology. - 2013. - Vol. 32, № 3. - P282-306. - Библиогр.: с. 305- 306 (80 ref.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
DISEASE PATHOGENESIS -- EFFECTIVE CURE -- MULTISCALE MODEl
Аннотация: Infections with HIV represent a great challenge for the development of strategies for an effective cure. The spectrum of diseases associated with HIV ranges from opportunistic infections and cancers to systemic physiological disorders like encephalopathy and neurocognitive impairment. A major progress in controlling HIV infection has been achieved by highly active antiretroviral therapy (HAART). However, HAART does neither eliminate the virus reservoirs in form of latently infected cells nor does it completely reconstitute immune reactivity and physiological status. Furthermore, the failure of the STEP vaccine trial and the only marginal efficacies of the RV144 trial together suggest that the causal relationships between the complex sets of viral and immunological processes that contribute to protection or disease pathogenesis are still poorly understood. Here, we provide an up-to-date overview of HIV-host interactions at the cellular, the immune system and the neuroendocrine systems level. Only by integrating this multi-level knowledge one will be able to handle the systems complexity and develop new methodologies of analysis and prediction for a functional restoration of the immune system and the health of the infected host

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10.
Инвентарный номер: нет.
   
   П 20

   
    Патоморфологическая характеристика травматического воспаления и репаративных процессов в роговице при экспериментальном проникающем ранении глаза в условиях иммуномодулирующей терапии / В. А. Черешнев, Т. В. Гаврилова, Р. Р. Файзрахманов [и др.] // Пермский медицинский журнал. - 2008. - Т. 25, № 3. - С. 54-58. - Библиогр.: с. 58 (10 назв.)
ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
ТРАВМАТИЧЕСКОЕ ВОСПАЛЕНИЕ -- РОГОВИЦА -- ИММУНОМОДУЛИРУЮЩАЯ ТЕРАПИЯ
Аннотация: The study of the effect of novel native immune modulator profetal (alphafetoprotein) as an active substance on the course of traumatic inflammation and reparative processes has been performed with experimental-biological model of penetrating wound of the eye in 36 Wistar rats. Histological and morphometric methods were used in this work. Profetal was applied alone and in combination with conventional therapy including glucocorticoids, antibiotics and non-steroid anti-inflammatory preparations. It was determined that the use of profetal both as monotherapeutic variant and in combined treatment suppressed the development of wound scarring and induced the processes of tissue defect recovery via reparative regeneration.

\\\\expert2\\nbo\\Электрон. библиотека (Отеч.периодика)\\Пермский медицинский журнал\\2008. Т. 25, №3. С. 54-58.pdf
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