Центральная Научная Библиотека УрО РАН

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   S 54

    Shmagel, K. V.
    Molecular bases of immune complex pathology [Electronic resource] / K. V. Shmagel, V. A. Chereshnev // Biochemistry. - 2009. - Vol. 74, № 5. - P469-479. - Bibliogr. : p. 477-479 (126 ref.)

ББК 57
Рубрики: БИОЛОГИЧЕСКИЕ НАУКИ
Кл.слова (ненормированные):
IMMUNE COMPLEXES -- COMPLEMENT -- CR1 RECEPTORS
Аннотация: The binding of antigens with antibodies forms immune complexes in the body. Usually these complexes are eliminated by the system of mononuclear phagocytes without development of pathological changes. This review highlights principal mechanisms responsible for safe removal of immune complexes in primates and humans. Special attention is given to diseases known as "immune complex diseases", when antigen-antibody complexes induce inflammatory reactions. The review considers key experimental works that significantly contributed to current knowledge of etiology and pathogenesis of type III hypersensitivity. Some factors of the development of immune complex syndrome such as level of humoral immune response to antigen, isotype and affinity of forming antibodies, the amount of immune complexes, and the consequences of their interaction with the complement system and Fc-receptors are analyzed based on the molecular mechanisms involved. The review contains a retrospective analysis of the most significant scientific achievements in immune complex pathology investigation within the last 100 years

\\\\expert2\\NBO\\Biochemistry\\2009, v.74, p. 469-479.pdf
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   C 51

    Chereshnev, V. A.
    Humans and Their Three Environments / V. A. Chereshnev, A. G. Gamburtsev, T. K. Breus // Herald of the Russian Academy of Sciences. - 2007. - Vol. 77, № 4. - P373-381. - Bibliogr. : p. 381 (8 ref.)

ББК Ч2
Рубрики: НАУКА. НАУКОВЕДЕНИЕ
Кл.слова (ненормированные):
ENVIRONMENTS -- HUMANS

\\\\expert2\\NBO\\Herald of the Russian Academy of Sciences\\2013, N3, p. 272-281.pdf
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   S 96

    Sviridova, T. G.
    Homoserine lactones and resorcinolic lipids inhibit In vitro pro-and anti-inflammatory cytokine production / T. G. Sviridova, D. G. Deryabin, V. A. Chereshnev // Research Journal of Immunology. - 2013. - Vol. 6, № 1. - P7-16. - Библиогр.: с. 14-16 (27 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
HOMOSERINE LACTONES -- RESORCINOLIC LIPIDS -- IMMUNE SYSTEM
Аннотация: Homoserine Lactones (HSLs) and Resorcinolic Lipids (RLs) originating from microbes and plants influence immune system, however, it is currently unclear whether HSLs and RLs are activators or suppressors of the cytokine network, especially in humans. A study has been carried out to investigate the effects of pure, synthetic HSLs and RLs with different chain lengths on pro-and anti-inflammatory cytokines produced by human blood monocyte cultures. Human monocytes (macrophages and lymphocytes) were collected from leukocyte-rich plasma, separated on a double density gradient, pre-treated with HSLs or Rls and then were inducted with standard either lipopolysaccharide or phytohemagglutinin stimulus. Quantitative assays for pro-and anti-inflammatory cytokines in the monocyte culture supernatants were performed using enzyme immunoassay kits for the quantitative determination of IL-1β, IL-2, IL-4, IL-10, TNF-α and IF-γ. We observed differences in cytokine production according to HSL and RL pre-treatment, increasing in the following order: IL-1β→IL-2≈IL-10≈TNF-α→IL-4→IF-γ. HSLs have been shown more pronounced inhibitory effects than Rls and long-chained homologs were more active than short-chained ones. Our study suggests that some small molecules originating from microbes and plants play an important role in cytokine network regulation and the immunomodulatory effect of HSLs and RLs may obstruct host defenses and affect inflammatory processes

\\\\expert2\\NBO\\Research Journal of Immunology\\2013. V. 6, N 1. P. 7-16.pdf
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   A 10


    A new experimental model of hemolytic anemia after butoxyethanol and the study of its immunology / V. A. Chereshnev, P. V. Kosareva, E. I. Samodelkin, L. V. Sivakova // Hellenic Journal of Nuclear Medicine. - 2014. - January-April. - P7-10. - Bibliogr. : p. 10 (12 ref.)

ББК 61
Рубрики: ЗДРАВООХРАНЕНИЕ. МЕДИЦИНСКИЕ НАУКИ
Кл.слова (ненормированные):
RATS - AUTOIMMUNITY BUTOXYETHANOL -- HEMOLYTIC ANEMIA
Аннотация: 2-butoxyethanol (C6H14O2) is widely used in many industrial reagents; according to the in vitro data it was established that 2- butoxyethanol metabolites are strong haemolytic poisons. Ghanayem B.I., Sullivan Ch.A. (1993) investigated in vitro the effect of BE on the red blood cells of 10 species of mammals, including humans. In this study, the authors established the species specificity with regard to the development of hemolytic anemia under the effect of butoxyethanol [4]. In the context of the available data, creation of experimental model based on the introduction of animal butoxyethanol is taking place. Since the druginduced hemolytic anemia is formed at the adjacency of toxic and autoimmune forms, the study of immunology of any toxic anemia is of great interest. Objective: to develop a new experimental model of hemolytic anemia after butoxyethanol and to study its immunology. In conclusion, the proposed model of hemolytic anemia after butoxyethanol may be used in the experimental and preclinical studies. The intraperitoneal administration of butoxyethanol provokes an autoimmune response directed against own red blood cells. The intraperitoneal administration of butoxyethanol to experimental animals is accompanied by a reduction of the lymphoid tissue that corresponds to the appropriate response to stress in the central and peripheral organs of immunogenesis

\\\\expert2\\nbo\\Hellenic Journal of Nuclear Medicine\\2014. P. 7-10.pdf
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